Abstract: Methods for the preparation of substantially purified populations of dendritic cells and monocytes from the peripheral blood of a mammal is described. Also described are vaccine compositions and methods for the treatment of certain diseases and medical conditions based on the substantially purified dendritic cells and monocytes.

Abstract: The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.

Abstract: A method for incorporating graphics into absorbent articles. The method involving: providing a moving substrate to a print cylinder; sensing a line speed reference signal from a line speed target machinery component; rotating the print cylinder at a predetermined speed, based on the line speed reference signal, to thereby print a series of graphics on the moving substrate at a predetermined distance frequency; sensing a phase difference signal from a phase target machinery component; and setting an actual print cylinder phase angle, based on the phase difference signal, to approximate a predetermined phase angle to thereby position the series of graphics on the moving substrate at a series of desired graphics locations. A system for executing the method and garments produced from the method and system are also provided.

Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. Modified integrin I-domain polypeptides that are stabilized in a desired conformation are also provided. Finally, screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention are also provided.

Abstract: An apparatus and method for depositing particulate matter onto a supply of absorbent core fibrous substrate material are disclosed. The apparatus has a feed tray that has an inlet for receiving a supply of particulate matter. At least part of a lower pan of the feed tray is a slideable shuttle pan that has an outlet edge located near a supply of absorbent core fibrous substrate material that is moving in a machine direction. The supply of particulate matter passes over the outlet edge to exit the feed tray. A mechanism operates the shuttle pan through a range of motion having a forward stroke and a backward stroke. During the forward stroke, the outlet edge follows the supply of absorbent core fibrous substrate material.

Abstract: A system, method, and apparatus for preparing an absorbent core for use in absorbent garments is disclosed. The apparatus includes a funnel having a first end and a second end, the second end being narrower in diameter than the first end, and a nozzle having a straight section, a curved section, and a tip. The straight section of the nozzle is operatively associated with the second end of the funnel. The apparatus further includes a diverter plate operatively associated with the curved section of the nozzle. The invention provides a more uniform distribution of super absorbent particles within the fluff pulp used to make the absorbent core, thus improving performance of the absorbent core. An absorbent garment made using an absorbent core made with the apparatus of the invention also is disclosed. The absorbent garment provides better leakage protection than absorbent garments incorporating conventional absorbent cores.

Abstract: An elastic assembly for absorbent garments having a first carrier layer, a second carrier layer, and an elastic layer attached between the first and second carrier layers to impart elasticity to an elasticized portion of the elastic assembly. The elastic layer is made of elastic strands having a decitex of about 600 or less. The elastic strands are arranged generally in parallel with one another and with a spacing of about 1 to about 10 elastic strands per centimeter. The elasticized portion of the elastic assembly has a thickness of about 2.6 mm or less at a pressure of 0.05 p.s.i. and about 8 or more corrugations per centimeter when in an elastically relaxed state. The first and second carrier layers are attached to one another in the elasticized portion substantially only by a coating of adhesive on the elastic strands. Absorbent garments incorporating the elastic assembly and a method of making the elastic assembly are also provided.

Abstract: The invention relates to an anti-amoebic vaccine containing an oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The anti-amoebic vaccines are particularly effective against inflammation and liver abscesses resulting from amoebic invasion when administered to patients.