Abstract: The present invention relates to a salt of carvedilol and/or corresponding solvates thereof, compositions containing such carvedilol and/or corresponding solvates thereof, and/or methods of using the aforementioned compound(s) in the treatment of certain disease states in mammals, in particular man. The present invention further relates to carvedilol phosphate salts, and/or solvates thereof, which include a novel crystalline form of carvedilol dihydrogen phosphate (i.e., which is the dihydrogen phosphate salt of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) and/or carvedilol hydrogen phosphate, etc.) and/or other corresponding solvates thereof, compositions containing these carvedilol phosphate salts and/or solvates, and methods of using the aforementioned salts and/or solvates to treat hypertension, congestive heart failure and angina, etc.
Type:
Grant
Filed:
November 24, 2004
Date of Patent:
July 6, 2010
Assignee:
SB Pharmco Puerto Rico Inc.
Inventors:
Christopher S. Brook, Pingyun Y. Chen, Wei Chen, Qunying Dai, Philip C. Dell'Orco, Clifford S. Labaw, Ann Marie Diederich, Choon K. Oh, Claire Hisler, David H. Igo, Lee M. Katrincic, Li-Jen Ping, Paul G. Spoors, Jun Wang, Christopher Werner