Abstract: Provided herein are optimized methods for performing multiplexed detection of a plurality of sequence variations. Also provided are methods for performing multiplexed amplification of target nucleic acid.

Abstract: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.

Abstract: Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.

Abstract: A delivery system and method for delivering a bifurcated intracorporeal device. The delivery system comprises a shaft having a distal section supporting a primary support member positioned to be disposed within at least a primary portion of the bifurcated intracorporeal device and a secondary support member extending within a secondary portion of the bifurcated intracorporeal device. At least one belt is configured to be circumferentially disposed about a portion of the secondary support member so to at least partially constrain the secondary portion of the bifurcated intracorporeal device. A tube defining a lumen is secured relative to the secondary support member. A release member is configured to engage and releasably secure the belt in a constraining configuration. The release member extends through at least a portion of the tube lumen such that the release member is accessible adjacent a proximal end of the tube.

Abstract: Systems and methods for testing samples, particularly biological samples are provided. The system includes an instrument for detecting molecules in samples, and a processor that communicates with the instrument to provide results-based control of the instrument to effect assay-based judging. For example, a system, including software, is provided that directs and performs assays such as diagnostic assays that employ a mass spectrometer. The output of the system, rather than a mass spectrum or other raw data form, is the diagnostic outcome, such as a genotype.

Abstract: Described herein are pipette tips that include rigid axial projections circumferentially disposed around the exterior surface of a relatively more compliant annular member. The rigid, axial projections may enable improved, and often optimal, sealing engagement with a dispensing device by (i) allowing deformation of the annular member between the projections, and (ii) restraining overall deformation of the annular member. Pipette tip embodiments described herein readily form a desired seal with a dispensing device, and permit ejection after use without modification to the dispensing device.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: Embodiments are directed to eluting coils having a relaxed coiled state and a straightened state that may be deployed at a fixed location within a patient's body and may accurately dispense and distribute fluids and or dissolvable substances at site specific locations of the body. Some embodiments of eluting elements are configured to be subsequently retrieved from a delivery site.

Abstract: Embodiments are directed to portable infusion devices, systems, and methods of using the same for dispensing materials. In some cases, the devices, systems and methods may be used for infusing a material such as medicament, e.g., insulin, into a body in need thereof.

Abstract: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.

Abstract: Methods and compositions for the optimization and production of refrigerator-temperature stable virus, e.g., influenza, compositions are provided. Formulations and immunogenic compositions comprising refrigerator-temperature stable virus compositions are provided.

Abstract: The technology relates in part to biological methods for producing adipic acid and engineered microorganisms capable of such production.

Abstract: A vibration damper assembly that may be attached and moved about a payload or optical mount surface of an optical structure such as an optical table. The vibration damper assembly may include a sensor and an actuator that may be disposed within a housing. In some embodiments, the vibration damper assembly or components thereof may be incorporated into an optical structure in the form of an optical component to be disposed or mounted on an optical mount surface of an optical structure such as an optical table. Embodiments of the vibration damper system may include a controller in communication with the damper assembly Embodiments of the controller may use adaptive tuning, auto-ranging selection of gain factors and other features in order to optimize damping performance.

Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Abstract: Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.