Abstract: The present invention generally relates to humanized VEGF and non-human transgenic animals expressing it. The transgenic animals are also useful to study VEGF-related therapies.

Abstract: Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.

Abstract: The invention provides anti-DLL4 antibodies, and compositions comprising and methods of using these antibodies.

Abstract: The present invention provides monoclonal antibodies, and portions thereof, which are capable of specifically binding to human vascular endothelial cell growth factor (hVEGF) or hVEGF-related protein. The invention also provides hybridoma cell lines that produce such monoclonal antibodies. The monoclonal antibodies of the invention are useful as therapeutic agents, either by themselves or in conjunction with cytotoxic or other chemotherapeutic agents, to treat diseases that are characterized by excessive vascular endothelial cell proliferation. The monoclonal antibodies of the invention also are useful in diagnostic and analytical methods for determining the presence of hVEGF or hVEGF related-protein in a test sample.

Abstract: Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.

Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch with modified viscosity properties and a modified phosphate content. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.

Abstract: Nucleic acid molecules are described, which encode debranching enzymes from maize, as well as transgenic plant cells and plants in which an amylopectin with modified properties is synthesized due to the expression of a debranching enzyme from maize or due to the inhibition of such an endogeneous debranching enzyme activity.

Abstract: The present invention relates to nucleic acid molecules encoding enzymes which are involved in the starch synthesis in plants. These enzymes are starch synthases from wheat. The invention further relates to vectors and host cells containing said nucleic acid molecules, in particular transformed plant cells and plants regenerated from these cells, which exhibit an increased or a reduced activity of the described starch synthases.

Abstract: The invention describes DNA molecules which code for plant proteins having the biological activity of a debranching enzyme. Furthermore described are transgenic plant cells and plants having reduced or increased debranching enzyme activity, as well as modified starch isolatable from the cells and plants.

Abstract: Nucleic acid molecules are described which encode enzymes involved in the starch synthesis in plants. These enzymes are starch phosphorylases from maize. The invention further relates to vectors containing such nucleic acid molecules and to host cells transformed with the described nucleic acid molecules, in particular to transformed plant cells and to plants which may be regenerated therefrom and which exhibit an increased or reduced activity of the described proteins.

Abstract: Nucleic acid molecules are described, which encode debranching enzymes from potato, as well as transgenic plant cells and plants in which an amylopectin with modified properties is synthesized due to the expression of a debranching enzyme from potato or due to the inhibition of such an endogeneous debranching enzyme activity.

Abstract: The invention describes DNA molecules which code for plant proteins having the biological activity of a debranching enzyme. Furthermore described are transgenic plant cells and plants having reduced or increased debranching enzyme activity, as well as modified starch isolatable from the cells and plants.

Abstract: Nucleic acid molecules are described encoding enzymes involved in the starch synthesis in plants. These enzymes are a novel isotype of soluble starch synthases from maize. Furthermore, the invention relates to vectors containing such nucleic acid molecules and to host cells, which have been transformed with said nucleic acid molecules, in particular to transformed plant cells or plants regenerable therefrom, which exhibit an increased or reduced activity of the described proteins.

Abstract: Nucleic acid molecules encoding enzymes which participate in the starch synthesis in plants are described. These enzymes are a novel isotype of starch synthase. Furthermore, the invention relates to vectors and hose cells which were transformed with the described nucleic acid molecules, in particular to transformed plant cells and to plants which may be regenerated therefrom and which exhibit an increased or reduced activity of the described proteins.

Abstract: The present invention describes transgenic plant cells and plants which due to a reduced activity of a disproportionating enzyme (D enzyme) synthesize a modified starch. Furthermore, the starch synthesized in these plant cells and plants is described.

Abstract: Nucleic acid molecules are described encoding a starch granule-bound protein from rice as well as methods and recombinant DNA molecules for the production of transgenic plant cells and plants synthesizing a modified starch. Moreover, the plant cells and plants resulting from those methods as well as the starch obtainable therefrom are described.

Abstract: The present invention relates to DNA molecules encoding enzymes which are involved in the starch synthesis of plants. These enzymes represent two different isotypes of the soluble starch synthase as well as a starch granule-bound starch synthase. This invention furthermore relates to vectors, bacteria, as well as to plant cells transformed with the DNA molecules described and to plants regenerated from them. Furthermore, the invention relates to starch that can be isolated from plants having an increased or reduced activity of the proteins described.

Abstract: Described is the use of the promoter region of the DefH9 gene of Anthirrhinum majus or of a promoter of a homologous gene displaying the same expression pattern and characteristics for the establishment of parthenocarpy or female sterility in plants, for increasing gynogenesis or for enhancing fruit setting and development. Also described are recombinant DNA molecules comprising a DefH9 promoter in combination with a DNA sequence which upon expression in plants leads to the above mentioned effects. Furthermore, described are plant cells and plants transformed with such recombinant DNA molecules.

Abstract: Nucleic acid molecules are described which encode enzymes involved in the starch synthesis in plants. These enzymes are starch phosphorylases from maize. The invention further relates to vectors containing such nucleic acid molecules and to host cells transformed with the described nucleic acid molecules, in particular to transformed plant cells and to plants which may be regenerated therefrom and which exhibit an increased or reduced activity of the described proteins.