Abstract: A non-volatile memory semiconductor device has a circuit to compensate for the variation in the data pattern to be programmed. The variation in the data patter creates a variation in the current requirement. The array receives a plurality of data pattern signals which affect the total amount of current flowing into a plurality of columns and into the memory array. A high voltage source generates an output which is supplied along a conducting path connected to the group of columns. A pass transistor is in the conducting path controlling the current flow in the conducting path. A current source has a first terminal and a second terminal with the first terminal connected to the output of the high voltage generator and the second terminal connected to the gate of the pass transistor. A plurality of current sources are collectively connected to a node.

Abstract: Nematodes, such as Caenorhabditis elegans, that express mutant and wild-type orthologs of human genes involved in polycystic kidney diseases (PKDs), are used to study the functions of the proteins encoded by the genes, to screen for other genes involved in the diseases, to identify mutations involved in the diseases, and to screen for drugs that affect PKD. Behaviors controlled by the action of the genes or gene products are identified and used in the assays. Hence an animal model is provided that permits study of the etiology of polycystic kidney disease and provides a tool to identify the genes involved in the disease pathway, and to identify compounds that may be used to treat or alter the disease progression, lessen its severity or ameliorate symptoms. The nematode genes that encode protein products, mutants of the genes, vectors that contain the genes and mutant genes and nematode strains that contain the vectors are also provided.

Abstract: Disclosed is a process of screening clones having DNA from an uncultivated microorganism for a specified protein, e.g. enzyme, activity by screening for a specified protein, e.g. enzyme, activity in a library of clones prepared by (i) recovering DNA from a DNA population derived from at least one uncultivated microorganism; and (ii) transforming a host with recovered DNA to produce a library of clones which is screened for the specified protein, e.g. enzyme, activity.

Abstract: An apparatus and method for allocating the resources of an organization in order to optimize the effects of that allocation on the quality of the organization, where the quality is viewed from a customer's perspective. The method includes the steps of acquiring the information required to construct a model of the organization's primary processes as viewed from the perspective of a customer. This information includes customer specific information such as customer inputs to the organization, customer outputs from the organization, and performance measures used by a customer to assess the quality of the outputs of the organization. Organization specific information such as the functional departments or units of the organization, and the inputs and outputs of each unit is also acquired.

Abstract: In addition to the known MT (magnetization transfer) effect, an RMT (reverse MT) is newly found, which increases a detected MR signal strength. Both the MT and RMT effects can be explained with mutual interaction, such as phenomena of chemical exchange and/or cross relaxation, acted between a pool of water proton spins and another pool of macromolecule proton spins, for example, within an object. In order to enhance the MT or RMT effect, the frequency bandwidths of RF pulses, such as a 90° RF exciting pulse in a SE or FSE method, an inversion pulse in a FLAIR or fast FLAIR method, and others, are controlled. To enhance the MT effect, the bandwidth is controlled into a wider value (approx. more than 1250 Hz) than the normally (conventionally) used bandwidth, while to obtain the RMT effect, the bandwidth is controlled into a narrower value (approx. less than 1000 Hz) than the normally used bandwidth. Actively controlling the MT or RMT effect permits changed image contrast in MR imaging.

Abstract: A drain cover assembly includes a closure device operable so as to close and open a drain hole in a cover plate of a drain cover unit. The closure device includes a pivot arm having a mounting portion connected pivotally to the cover plate, a flow control portion extending from and disposed on a first side of the mounting portion and registered with the drain hole, and a weighted portion extending from and disposed on a second side of the mounting portion and having a weight sufficient to overcome the weight of the flow control portion so as to cause the pivot arm to pivot from an open position to a normal closed position. The pivot arm pivots to the open position when the flow control portion is subjected to an applied load through the drain hole that is sufficient to overcome the weight of the weighted portion.

Abstract: A logic circuit section comprises a plurality of first transistors of a first conductivity type and a plurality of second transistors of a second conductivity type, and is controlled according to an input signal. A third transistor of the first conductivity type supplies power to the logic circuit section. A fourth transistor of the second conductivity type is connected to the output terminal of the logic circuit section, and sets a level at the output terminal when the logic circuit section does not operate. The first and second transistors are controlled by a first control signal, and the third transistor is controlled by a second control signal different from the first control signal.

Abstract: An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.

Abstract: Methods, systems and devices are described relating to a chassis for front and back inserted modules. An apparatus includes a chassis including a first module bay and a second module bay, the first module bay and the second module bay together composing both a forward section and rearward section.

Abstract: A fast-setting, bioresorbable calcium phosphate cement is prepared by a process which can be carried out with a heat treatment up to 1000° C. on a mixture of a wetting solution and a calcium phosphate powder having a Ca to P molar ratio of 0.5-2.5. The wetting solution suitable for use in the process of the present invention includes water, an organic solvent, an acidic and basic solution. A setting solution for mixing with the heated powder to form the fast-setting, bioresorbable calcium phosphate cement may be water, an acidic or basic solution according to the process of the present invention.

Abstract: A high shunt regulator provides precise voltage over process, temperature, power supply, and foundries. The HV level is settable by a digital control bits such as fuse bits. A filter network filters out the ripple noise and charge transient. A tracking capacitor divider network speeds up response time. A fractional band gap reference provides fractional bandgap voltage and current, and operates at low power supply and has superior power supply rejection. It is unsusceptible to substrate hot carrier effect. It exposes very little to drain induced barrier lowering effect. The bandgap core has better than conventional transient response and stability. One embodiment has adjustable level control. Complementary TC (temperature coefficient) trimming allows efficient realization of zero temperature coefficients of current and voltage. Higher order curvature correction of voltage and current is integrated. Replica bias for the control loop is presented.

Abstract: A memory system includes manufacturer identifiers, such as serial numbers and part numbers, stored in locations of memory that are unalterable by end users. A customer identification location of the memory allows the user to program its own identifier and includes a locking code that prevents subsequent alteration of the customer identification location. A recall procedure at power on verifies the content of the locked code for allowing alteration of the memory.

Abstract: A clock non-synchronous type circuit performs data read operation on the basis of a read control signal. After a lapse of a predetermined delay time, read data is read out from the clock non-synchronous type circuit. The read data is latched in selected one of N latch circuits. A latch circuit is selected on the basis of a control signal instead of a clock signal. The control signal represents that read data is output from the clock non-synchronous type circuit, and hence a latch circuit is always selected after read data is output.

Abstract: The semiconductor device includes an input/output circuit, a functional module, an electrostatic discharge protection circuit and bumps. The input/output circuit is formed close to an edge of the semiconductor chip. The functional module is formed on the semiconductor chip located on a central side with regard to the input/output circuit. The electrostatic discharge protection circuit is formed in the functional module of the semiconductor chip and serves to protect a circuit located in a downstream thereof, from being destructed by electrostatic discharge. The bumps are arranged on one of major surfaces of the semiconductor chip located close to the functional module, and they are connected to the functional module via the electrostatic discharge protection circuit.

Abstract: This invention provides a method for identifying one or more complexes from a library of complexes, wherein said complex or complexes are selected for their ability to perform a preselected or desired function on a target molecule or by having a pre-selected structure, each complex being designated a morphatide, said method comprising: (a) preparing a library of morphatides, comprised of: (i) a scaffolding component selected from the group consisting of nucleic acid, nucleic acid like molecule or nucleic acid analog having one or more regions of randomized sequence; (ii) one or more linker components; and (iii) one or more agent molecules or type of agent molecules, linked to the scaffolding component by one or more type of linker components; and (b)screening the library of morphatides prepared in step (a) by contacting, binding, or associating the morphatides with one or more suitable target molecules upon which a morphatide performs a preselected or desired function or to which a morphatide binds or associa

Abstract: The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid receptor beta (RAR&bgr;), estrogen receptor (ER), cyclin D2, WT-1, 14.3.3 sigma, HIN-1, RASSF1A, and combinations of such genes serve as markers of breast malignancy.

Abstract: A common bias section is composed of a first series circuit having an internal resistor and an external resistor connected in series and an operational amplifier having a first input terminal connected to a reference voltage, a second input terminal connected to a Vr1 node, and an output terminal connected to the series circuit. An impedance trimming section is composed of a series circuit having an internal resistor and an impedance dummy resistor connected in series, a comparator CMP having a first input terminal connected to the Vr1 node and a second input terminal connected to a Vto1 node, a code control circuit which uses a clock signal to latch an output signal from the comparator to generate a plurality of switching codes, and a switching circuit which switch a resistance value of the impedance dummy resistor.

Abstract: A method, apparatus, and system for optically sorting and/or manipulating carbon nanotubes by creating an optical dipole trap with a focused light source (e.g., a laser) are described in detail herein. In one representative embodiment, light from the light source may be directed onto a mixture of carbon nanotubes, the mixture including a target class of carbon nanotubes having dimensions (e.g., length and diameter) corresponding to particular electronic properties suitable for an application. By identifying a resonant condition corresponding to the target class of carbon nanotubes, and tuning the light source substantially to the resonant condition, an optical dipole trap may be created to attract carbon nanotubes of the target class to allow manipulation and/or sorting of the target class of carbon nanotubes from the mixture, or rotation of the nanotubes via rotation of a plane of polarization of the light, in an embodiment.

Abstract: A flexible tissue injection catheter is used to accomplish injections at a precisely controlled depth of precisely controlled volumes of a therapeutic or diagnostic agent into an interior body cavity, such as the epicardium or myocardium of the heart. In one embodiment, the invention method includes repeated injections at spaced intervals along the myocardium or epicardium of sterile fluid containing autologous bone marrow aspirate to promote angiogenesis. For myocardial injection, depth penetration is controlled by using a catheter that allows the operator to control depth penetration by means of an adjustable needle stop attached to the catheter handle. In another embodiment depth penetration during epicardial injections is controlled by use of an injection catheter having an operator-controlled adjustable needle stop that produces a sensible signal, such as a visible or audible signal, marking each increment of needle tip exposed by operation of the adjustable needle stop.