Abstract: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter operably linked to the DNA segment; and a transgene operably linked to a second promoter; b) a BIV packaging vector construct comprising a BIV DNA sequence fragment comprising at least a gag gene or pol gene of BIV; a promoter operably linked to the BIV DNA fragment; and a polyadenylation sequence located downstream of the BIV DNA fragment; and c) an expression vector construct comprising a gene encoding a viral surface protein. Also provided is a method for transferring a gene of interest into a mammalian cell.

Abstract: A system, method, and computer program for automatically generating text analysis systems is disclosed. Individual passes of a multi-pass text analyzer are created by generating rules from samples supplied by users. Successive passes are created in a cascading fashion by performing partial text analyses employing existing passes. A complete text analyzer interleaves the generated passes with a framework of existing passes. The complete text analysis system can then process texts to identify patterns similar to samples added by users. Generation of rules from samples encompasses a wide range of constructs and granularities that occur in text, from individual words to intrasentential patterns, to sentential, paragraph, section, and other formats that occur in text documents.

Abstract: A nonvolatile reprogrammable switch for use in a PLD or FPGA has a nonvolatile memory cell connected to the gate of an MOS transistor with the terminals of the MOS transistor connected to the source of the signal and to the circuit. The nonvolatile memory cell is of a split gate type having a first region and a second region, with a channel therebetween. The cell has a floating gate positioned over a first portion of the channel, which is adjacent to the first region and a control gate positioned over a second portion of the channel, which is adjacent to the second region. The second region is connected to the gate of the MOS transistor. The cell is programmed by injecting electrons from the channel onto the floating gate by hot electron injection mechanism. The cell is erased by Fowler-Nordheim tunneling of the electrons from the floating gate to the control gate. As a result, no high voltage is ever applied to the second region during program or erase.

Abstract: A voltage down converter 10 for providing a supply voltage and current to a device, such as a semiconductor device. The voltage down converter includes a first circuit 12 that supplies steady state or “DC” current to the device, and a second circuit 14 that supplies the fluctuating or “AC” current to the device. The first circuit 12 includes a first comparator 18 that drives a first transistor P1 to supply most of the steady state current. The second circuit 14 includes a second comparator 20, which is larger than the first comparator 18, and which drives a second transistor P2, which is smaller than the first transistor P1, to supply the fluctuating current to the device. The converter 10 further includes a feedback circuit 16 for controlling the supply voltage.

Abstract: Zinc finger proteins of the Cys2His2 type represent a class of malleable DNA binding proteins which may be selected to bind diverse sequences. Typically, zinc finger proteins containing three zinc finger domains, like the murine transcription factor Zif268 and the human transcription factor Sp1, bind nine contiguous base pairs (bp). To create a class of proteins which would be generally applicable to target unique sites within complex genomes, the present invention provides a polypeptide linker that fuses two three-finger proteins. Two six-fingered proteins were created and demonstrated to bind 18 contiguous bp of DNA in a sequence specific fashion. Expression of these proteins as fusions to activation or repression domains allows transcription to be specifically up or down modulated within cells. Polydactyl zinc finger proteins are broadly applicable as genome-specific transcriptional switches in gene therapy strategies and the development of novel transgenic plants and animals.

Abstract: 53 Systems and methods are described for an interferometric source of multi-color, multi-beam entangled photons.

Abstract: A control architecture for an optical burst-switched network includes an electronic ingress edge router, a switch control unit at each hop, and an electronic egress edge router. The electronic ingress edge router assembles multiple data packets into a burst. The switch control units at each hop configure the optical switching matrix to switch the burst through the optical burst-switched network. Finally, the electronic egress edge router receives the burst from the optical burst-switched network and disassembles the burst into multiple data packets.

Abstract: A method for controlling the gas flow within a digital mass flow controller. The method calculates a digitally enhanced flow rate signal that more accurately represents an actual flow rate through the digital mass flow controller. The digitally enhanced flow rate is calculated using a sensed flow rate signal output from a flow sensor, a scaled first derivative of the sensed flow rate signal, and a scaled, filtered second derivative of the sensed flow rate signal. A set-point signal is compared to the digitally enhanced flow rate signal to generate a digital error signal. The digital error signal is provided to a digitally realized PI (proportional integral) controller. The PI controller generates a digital control signal which is used to control a valve in the digital mass flow controller.

Abstract: A method for creating a trench for high voltage isolation begins by forming a trench in the substrate having sidewalls and a bottom surface. Spacers are formed along the sidewalls of a trench with the spacers partially covering the bottom surface. A barrier layer is formed on the portion of the bottom surface not covered by the spacers. The spacers are then removed, exposing the bottom surface not covered by the barrier layer. The bottom surface is then further etched to create a second deeper trench which has sidewalls and bottom surface. An insulating layer is then conformally deposited to cover the surface of the substrate including filling the first and second trenches.

Abstract: A semiconductor integrated circuit which is capable of being manufactured with a higher packing density and a small-size structure of standard cells is described. In the semiconductor integrated circuit, substrate regions and source regions are shared by adjacent standard cells as well as common contact regions which are located inward displaced respectively from the centers of the substrate regions.

Abstract: An antigenic preparation is provided which contains a 31 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism.

Abstract: A variable tilt angle shoulder prosthesis includes a variable tilt angle, comprising a head component including a proximal portion configured to interface with a glenoid process and a distal surface including a socket depression defined therein; a humeral shaft; a humeral neck at the end of the shaft including a proximal ball end which is configured to couple with the socket depression of the humeral head as a ball-in socket joint, adjustable, upon coupling with said humeral neck, to a selected tilt angle among a plurality of tilt angles relative to an elongate direction of said shaft to substantially match said prosthesis to a natural tilt angle of a humeral head of a patient.

Abstract: A method and system are disclosed for reconciling extended copy command target descriptor lengths.

Abstract: Method and apparatus for isolating active regions in an electrically programmable and erasable memory device. A first layer of insulating material is formed on a substrate. A layer of conductive material is formed on the first layer of insulating material. A plurality of spaced apart trenches are formed through the first layer of insulating material, the layer of conductive material, and into the substrate. A second layer of insulation material is formed on sidewall portions of the trenches. A block of insulation material is formed in the trenches. For each of the trenches, an edge portion of the layer of conductive material extends over and overlaps with the first layer of insulating material and possibly a portion of the insulation material block by a predetermined distance &Dgr;.

Abstract: Systems and methods for pulse-transmission low-power communication modes are disclosed. A pulse transmission receiver includes: a front-end amplification/processing circuit; a synchronization circuit coupled to the front-end amplification/processing circuit; a clock coupled to the synchronization circuit; a trigger signal generator coupled to the clock; and at least one higher-order time derivative pulse generator coupled to the trigger signal generator. The systems and methods significantly reduce lower-frequency emissions from pulse transmission spread-spectrum communication modes, which reduces potentially harmful interference to existing radio frequency services and users and also simultaneously permit transmission of multiple data bits by utilizing specific pulse shapes.

Abstract: A method, systems and apparatus for providing true-time-delayed signals using optical inputs is disclosed. In one aspect a system for providing optical true-time-delayed signals is provided. The system includes at least one optical source having emitting an optical signal having a predetermined wavelength, an optical waveguide optically coupled to the at least one optical source, and a diffraction element optically coupled to the waveguide, the diffraction element positioned along the waveguide at a predetermined distance.

Abstract: Disclosed is a process for identifying clones having a specified activity of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly isolated from the environment; and (ii) screening said libraries utilizing an assay system. More particularly, this is a process for identifying clones having a specified activity of interest by (i) generating one or more expression libraries derived from nucleic acid directly or indirectly isolated from the environment; (ii) exposing said libraries to a particular substrate or substrates of interest; and (iii) screening said exposed libraries utilizing a fluorescence activated cell sorter to identify clones which react with the substrate or substrates.

Abstract: A hybrid three-axis magnetic sensor for calculating the accurate direction of the earth magnetism. The hybrid three-axis magnetic sensor includes: a flux gate type magnetic sensor which is so formed that a base serves as a main member and detects two axis components of a magnetic vector defined by a plane parallel to the base; a Hall element which detects another component of the magnetic vector orthogonal to the base; a tilt sensor which detects a tilt angle of the base; and a CPU, wherein the flux gate type magnetic sensor and the Hall element are integrally structured together as a hybrid IC. The thus detected three dimensional magnetic vector is corrected in the light of inclination of the base, so that the direction of the earth magnetism is accurately calculated.

Abstract: The present invention relates to a completely implantable intracranial pressure monitor, which can couple to existing fluid shunting systems as well as other internal monitoring probes. The implant sensor produces an analog data signal which is then converted electronically to a digital pulse by generation of a spreading code signal and then transmitted to a location outside the patient by a radio-frequency transmitter to an external receiver. The implanted device can receive power from an internal source as well as an inductive external source. Remote control of the implant is also provided by a control receiver which passes commands from an external source to the implant system logic. Alarm parameters can be programmed into the device which are capable of producing an audible or visual alarm signal. The utility of the monitor can be greatly expanded by using multiple pressure sensors simultaneously or by combining sensors of various physiological types.

Abstract: Improvements to the acquisition and replay systems for direct-to-digital holography and holovision are described. A method of recording an off-axis hologram includes: splitting a laser beam into an object beam and a reference beam; reflecting the reference beam from a reference beam mirror; reflecting the object beam from an illumination beamsplitter; passing the object beam through an objective lens; reflecting the object beam from an object; focusing the reference beam and the object beam at a focal plane of a digital recorder to form an off-axis hologram; digitally recording the off-axis hologram; and transforming the off-axis hologram in accordance with a Fourier transform to obtain a set of results. A method of writing an off-axis hologram includes: passing a laser beam through a spatial light modulator; and focusing the laser beam at a focal plane of a photorefractive crystal to impose a holographic diffraction grating pattern on the photorefractive crystal.