Abstract: A low-expanding adhesive composition comprising: a diisocyanate, a surfactant and an activator is provided. The provided adhesive composition cures upon exposure to water. The adhesive composition can be used to bond wood, metal, glass, ceramic, leather, acrylic, PVC and combinations thereof.

Abstract: The present invention provides systems and methods for accurately characterizing thermodynamic and materials properties of electrodes and electrochemical energy storage and conversion systems. Systems and methods of the present invention are configured for simultaneously collecting a suite of measurements characterizing a plurality of interconnected electrochemical and thermodynamic parameters relating to the electrode reaction state of advancement, voltage and temperature.

Abstract: A process for production of a microporous affinity membrane having regioselective affinity for compounds in blood or other biologically active fluids to be removed during purification of blood or said fluids is disclosed, as well as a microporous affinity membrane produced by said process, an adsorption device containing such a microporous affinity membrane, and use of such a microporous affinity membrane.

Abstract: The membrane scaffold proteins (MSP) of the present invention assemble with hydrophobic or partially hydrophobic proteins to form soluble nanoscale particles which preserve native structure and function; they are improved over liposomes and detergent micelles, in terms of stability and preservation of biological activity and native conformation. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles, which are robust in terms of integrity and maintenance of biological activity of incorporated proteins, facilitate pharmaceutical and biological research, structure/function correlations, structure determinations, bioseparations, and drug discovery.

Abstract: The present invention provides methods for conformally or superconformally coating and/or uniformly filling structures with a continuous, conformal layer or superconformal layer. Methods of the present invention improve conformal or superconformal coverage of surfaces and improve fill in recessed features compared to conventional physical deposition and chemical deposition methods, thereby minimizing formation of voids or gaps in a deposited conformal or superconformal layer. The present methods are capable of coating or filling features useful for the fabrication of a broad class of electronic, electrical and electromechanical devices.

Abstract: A working machine includes a working arm, the arm in use, carrying a working implement, the arm being raisable and lowerable about a generally horizontal axis by a power operated device, a cab structure for an operator, an engine for providing power to a ground engaging drive structure to drive the machine over the ground and for operating the working arm, each of the working arm, the cab structure and the engine being mounted on a machine chassis, and the machine being characterized in that the chassis includes a single primary chassis member which provides a substantial resistance to torsional deformation of the machine between the front and rear ends of the machine, the single primary chassis member including a first part which extends longitudinally of the machine at the one side of the machine, and a second part which extends transversely of the first part at or towards one end of the machine.

Abstract: A patterned phosphor structure, and EL laminate containing same, forming red, green, and blue sub-pixel phosphor elements for an AC electroluminescent display. The patterned phosphor structure includes at least a first and a second phosphor emitting light in different ranges of the visible spectrum, but with combined emission spectra contains red, green, and blue light, the first and second phosphors being in a layer, arranged in adjacent, repeating relationship to each other to provide a plurality of repeating first and second phosphor deposits. Photolithographic methods for producing the patterned phosphor structure are also provided. Also provided is an improved dielectric layer for use in an EL laminate, including a pressed, sintered ceramic material having, compared to an unpressed, sintered dielectric layer of the same composition, improved dielectric strength, reduced porosity and uniform luminosity in an EL laminate.

Abstract: The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to such patients during non-bleeding periods. This invention is based on the discovery that the recombinant B-domainless porcine fVIII, termed OBI-1, has greater bioavailability compared to the natural porcine fVIII partially purified from porcine plasma, termed HYATE:C. Therefore, the inventive method employs lower unit doses of OBI-1, including, alternatively, omission of antibody-neutralizing dosage, or has longer intervals between the administration, compared to HYATE:C, to provide equivalent protection in patients having fVIII deficiency.

Abstract: Membrane proteins are difficult to express in recombinant form, purify, and characterize, at least in part due to their hydrophobic or partially hydrophobic properties. Membrane scaffold proteins (MSP) assemble with target membrane or other hydrophobic or partially hydrophobic proteins or membrane fragments to form soluble nanoscale particles which preserve their native structure and function; they are improved over liposomes and detergent micelles. In the presence of phospholipid, MSPs form nanoscopic phospholipid bilayer disks, with the MSP stabilizing the particle at the perimeter of the bilayer domain. The particle bilayer structure allows manipulation of incorporated proteins in solution or on solid supports, including for use with such surface-sensitive techniques as scanning probe microscopy or surface plasmon resonance. The nanoscale particles facilitate pharmaceutical and biological research, structure/function correlation, structure determination, bioseparation, and drug discovery.

Abstract: Methods and related devices are provided for probing a surface by application of a hyperpolarized noble gas having a nuclear electric quadrupole moment to the surface. In an embodiment, the hyperpolarized noble gas is substantially free of alkali metal vapor, such as rubidium vapor used to hyperpolarize the noble gas. Noble gas interaction with the surface of interest is detected by measuring quadrupolar-driven events such as T1, T2 relaxation or coherent processes by nuclear magnetic resonance spectroscopy or by magnetic resonance imaging, for example. The method is capable of probing a variety of surfaces that are difficult to analyze by conventional methods, including biological or non-biological surfaces, to obtain detailed and reliable information related to surface chemical composition.

Abstract: A liquid particle counter for optically detecting an unconstrained particle suspended in a flowing liquid includes a sample chamber having a liquid inlet and a liquid outlet; a laser diode module producing a symmetrically collimated laser beam; a beam shaping optical system directing the laser beam at the sample chamber; and an optical detector located to detect light scattered by the particle in the sample chamber, the detector producing an electric signal characteristic of a parameter of the particle. The laser beam has an energy of a watt or more and passed through an aperture in a black glass aperture element in the sample chamber. The black glass aperture element removes diffracted and stray light from the beam without damage to the sample chamber.

Abstract: The invention relates to optical sensor measurement methods that use a swept wavelength optical source to determine wavelength shift as well as to optical sensor systems that embody and employ these methods. A variable scan rate swept optical source is used to determine the optical path length from the optical interrogator to the optical sensors being measured. This data can then be used as desired or needed in implementing the sensor or making sensor measurements. In particular the data can be used in the optical sensor system to compensate for potential measurement errors due to the finite speed of light in the optical medium interconnecting optical sensors under test.

Abstract: Disclosed is are gene sequences encoding ?-tocopherol methyltransferases from photosynthetic organisms. The enzyme ?-tocopherol methyltransferase catalyzes the methylation of ?-tocopherol to yield ?-tocopherol, the most bioactive species of tocopherol. ?-tocopherol methyltransferase is believed to be involved in regulating the relative amounts of the various tocopherols present in photosynthetic organisms. By introducing a genetic construct having a ?-tocopherol methyltransferase coding sequence placed under the control of a plant promoter into a plant, transgenic plants can be made having altered ?-tocopherol methyltransferase expression, to effect dramatic changes in the tocopherol profile of the plant. Transgenic plants can be made that have ?-tocopherol as the predominant tocopherol in their seeds and oils.

Abstract: T cell receptors (TCRS) that have higher affinity for a ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate a variegated population of mutants of the T cell receptor protein coding sequence; transforming the T cell receptor mutant coding sequence into yeast cells; inducing expression of the T cell receptor mutant coding sequence on the surface of yeast cells; and selecting those cells expressing T cell receptor mutants that have higher affinity for the peptide/MHC ligand than the wild type T cell receptor protein. The high affinity TCRs can be used in place of an antibody or single chain antibody.

Abstract: A gate valve for controlling fluid flow, with a valve body forming a cylindrical flowbore and a gate cavity intersecting the flowbore to provide opposed openings. Seat pockets formed in the opposed openings may optionally include a metal carrier ring. A non-metallic bridging seal formed as a face seal is provided between the first seal surface of the annular seat element and the seat pocket. The bridging seal bridges any gap formed at the first seal surface such that sealing engagement is maintained across the gap at all times as the gate moves between open and closed positions, while still permitting limited axial movement of the annular seat element. Preferred embodiments of the bridging seal include tongue and groove seals and bridge ring inserts. A secondary seal to the seat pocket may be included as a corner, periphery or face seal, for example as an O-ring, U-ring or wiper seal.

Abstract: Subfluorinated graphite fluorides of formula CFx wherein CFx is in the range of 0.06 to 0.63, e.g., 0.10 to 0.46, are used as electrode materials in electrochemical devices that convert chemical energy to electrical current, e.g., batteries. The invention additionally provides methods of manufacturing electrodes with the subfluorinated graphite fluorides, as well as primary and secondary batteries containing such electrodes.

Abstract: Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of hemophiliacs, especially those undergoing bleeding episodes.

Abstract: The invention provides methods and devices for fabricating printable semiconductor elements and assembling printable semiconductor elements onto substrate surfaces. Methods, devices and device components of the present invention are capable of generating a wide range of flexible electronic and optoelectronic devices and arrays of devices on substrates comprising polymeric materials. The present invention also provides stretchable semiconductor structures and stretchable electronic devices capable of good performance in stretched configurations.

Abstract: A method for the preparation of a compound of general Formula: or pharmaceutically acceptable derivatives and salts, racemates, isomers and/or tautomers thereof comprising cyclizing an azomethine ylide of general Formula: wherein, A is a cyclic or non-cyclic group; Z is a carbon or a heteroatom; n is selected from 0, 1, 2 or 3; W, X and Y may be the same or different and each are selected from hydrogen; optionally substituted alkyl, alkenyl, alkynyl, amino, alkoxy, alkenoxy, alkynoxy, aryl, alkylthio, heterocyclyl; carboxy, carboxy ester, carboxamido, acyl, acyloxy, mercapto, halogen, nitro, sulfate, phosphate, cyano and optionally protected hydroxy; or W and X, together with the nitrogen and carbon atoms to which they are attached, form a saturated or unsaturated nitrogen containing heterocyclic group which may be optionally substituted or optionally fused to a saturated or unsaturated carbocyclic group, aryl group or heterocyclic group is provided.

Abstract: A new and distinct cultivar of Hydrangea macrophylla plant named ‘PIIHM-I’, characterized by its upright, rounded and spreading growth habit; remontant flowering (reblooming, flowers on new growth); bright pink lacecap inflorescences; dark green, powdery mildew resistant foliage, orange to rich rose-red to red-purple fall color; and pink-red stems.