Abstract: A structural glass panel railing includes glass panels supported on a floor by a base assembly including a railing support assembly. The railing support assembly includes a shoe fastened to the floor, a base member locked to the shoe by a cam lock lever and a channel member having a pocket receiving the panel. The base member may be attached directly to the floor. The channel member is received in a groove of the base member and is held by a wedge system. The wedge system can be formed by mating tapers on the channel member and the groove or by a wedge member inserted into the groove. A handrail assembly includes a handrail channel member receiving the top edge of the panel. The handrail channel member is received in a groove in a handrail.