Abstract: New spirofluoreneisothiazolidinone dioxides and methods for their preparation are disclosed.

Abstract: Topical ophthalmic compositions containing microfine particles of one or more retinoids are described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.

Abstract: An intraocular lens for replacing the natural lens of an eye including a pair of flexible loops connected to and projecting from the optic portion on one side of the first axis, adapted for supporting the IOL in the eye. The loops include outer end portions that terminate outwardly from the peripheral edge and on opposite sides of the second axis. A stabilizing member(s) is connected to and projects from the optic portion on the other side of the first axis from where the loops are connected, adapted for stabilizing the IOL in the eye. The flexible loops and stabilizing member(s) is shaped and dimensioned so that when the loops are moved toward the peripheral edge the outer end portions do not extend beyond the stabilizing member(s).

Abstract: Angiostatic steroids for use in controlling ocular hypertension are disclosed. Pharmaceutical composition of the angiostatic steroids and methods for their use in treating ocular hypertension, including controlling the ocular hypertension associated with primary open angle glaucoma, are disclosed.