Abstract: The invention relates to reshaped human monoclonal antibodies directed against isotypic determinants of immunoglobulin E (IgE), direct equivalents and derivatives of said antibodies. The molecules of the invention are useful for diagnostics, prophylaxis and treatment of allergy.
Type:
Grant
Filed:
September 27, 1993
Date of Patent:
May 23, 2000
Assignees:
Novartis Corporation, Tanox Biosystems, Inc.
Inventors:
Norman Hardman, Frank Kolbinger, Jose Saldanha