Patents Represented by Attorney, Agent or Law Firm Gregory L. Heinkel
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Patent number: 6475808Abstract: Protein arrays for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein arrays are also disclosed. On the arrays, a plurality of different proteins, such as different members of a single protein family, are immobilized on one or more organic thinfilms on the substrate surface. The protein arrays are particularly useful in drug development, proteomics, and clinical diagnostics.Type: GrantFiled: July 14, 1999Date of Patent: November 5, 2002Assignee: Zyomyx, IncorporatedInventors: Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
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Patent number: 6475809Abstract: Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.Type: GrantFiled: May 12, 2000Date of Patent: November 5, 2002Assignee: Zyomyx, IncorporatedInventors: Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
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Patent number: 6406921Abstract: Protein arrays and protein-coated substrates for the parallel, in vitro screening of biomolecular activity are provided. Methods of using the protein-coated substrates and protein arrays are also disclosed. A plurality of different members of a single protein family may be immobilized on the protein-coated substrate or array. The protein-coated substrates and protein arrays are particularly useful in high-throughput drug screening and clinical diagnostics.Type: GrantFiled: July 14, 1998Date of Patent: June 18, 2002Assignee: Zyomyx, IncorporatedInventors: Peter Wagner, Dana Ault-Riche, Steffen Nock, Christian Itin
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Patent number: 6365418Abstract: Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.Type: GrantFiled: May 18, 2000Date of Patent: April 2, 2002Assignee: Zyomyx, IncorporatedInventors: Peter Wagner, Steffen Nock, Dana Ault-Riche, Christian Itin
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Patent number: 6329209Abstract: Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.Type: GrantFiled: July 14, 1999Date of Patent: December 11, 2001Assignee: Zyomyx, IncorporatedInventors: Peter Wagner, Steffen Nock, Dana Ault-Riche, Christian Itin
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Patent number: 6309375Abstract: A modular drug delivery system for use by cardiothoracic surgeons and interventional cardiologists for delivery of molecular and cellular therapies that target genes, molecules and peptides. The regulated drug delivery devices comprise a modular mechanically actuated drug delivery module (DDM) that can be attached to either a surgical viewing endoscope hand-piece or specialized catheter for interventional procedures. The DDM provides metering of drugs to treatment sites and allows for quick interchangeability with other component parts such as a viewing scope end portion for MIS or other surgical procedures or a flexible catheter shaft for percutaneous procedures.Type: GrantFiled: May 18, 1999Date of Patent: October 30, 2001Assignee: MicroHeart, Inc.Inventors: Robert C. Glines, Richard D. Phipps, Lauren K. Lundquist, Daniel S. Brown
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Patent number: 6228326Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface.Type: GrantFiled: November 26, 1997Date of Patent: May 8, 2001Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Steven G. Boxer, Nick Ulman, Jay T. Groves
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Patent number: 6183444Abstract: A modular drug delivery system for use by cardiothoracic surgeons and interventional cardiologists for delivery of molecular and cellular therapies that target genes, molecules and peptides. The regulated drug delivery devices comprise a modular mechanically actuated drug delivery module (DDM) that can be attached to either a surgical viewing endoscope hand-piece or specialized catheter for interventional procedures. The DDM provides metering of drugs to treatment sites and allows for quick interchangeability with other component parts such as a viewing scope end portion for MIS or other surgical procedures or a flexible catheter shaft for percutaneous procedures.Type: GrantFiled: May 16, 1998Date of Patent: February 6, 2001Assignee: MicroHeart, Inc.Inventors: Robert C. Glines, Richard D. Phipps, Lauren Lundquist, Daniel S. Brown
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Patent number: D486156Type: GrantFiled: June 27, 2001Date of Patent: February 3, 2004Assignee: Fluidigm CorporationInventors: Michael Lee, Yong Yi
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Patent number: D488818Type: GrantFiled: June 27, 2001Date of Patent: April 20, 2004Assignee: Fluidigm CorporationInventors: Michael Lee, Yong Yi