Abstract: Compounds having the formula: ##STR1## wherein X is either (a) a phenyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and hydroxy, or (b) a thienyl group; and Y is an imidazolyl, pyrazolyl, triazolyl or tetrazolyl group optionally substituted by 1 or 2 substituents each independently selected from halo, CF.sub.3, C.sub.1 -C.sub.4 alkoxy, hydroxy and amino; and pharmaceutically acceptable salts thereof, are antimuscarinic bronchodilators useful in the treatment of chronic obstructive airways disease and asthma.

Abstract: The invention provides a process for preparing a compound of the formula: ##STR1## or a base salt thereof, wherein R.sup.2 is hydrogen or C.sub.1 -C.sub.6 alkyl optionally substituted by up to 3 substituents each independently selected from the group consisting of C.sub.1 -C.sub.6 alkoxy and C.sub.1 -C.sub.6 alkoxy(C.sub.1 -C.sub.6 alkoxy)-; and R.sup.3 is C.sub.1 -C.sub.6 alkyl or benzyl, said benzyl group being optionally ring-substituted by up to 2 nitro or C.sub.1 -C.sub.4 alkoxy substituents comprising reacting a compound of the formula: ##STR2## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl, phenyl or benzyl or C.sub.1 -C.sub.4 alkoxy; and R.sup.2 and R.sup.3 are as previously defined for a compound of the formula (I), with hydrogen peroxide or a source of peroxide ions: said process being optionally followed by conversion of the compound of the formula (I) to a base salt thereof. The present invention also relates to novel compounds of the formula (II).

Abstract: Improved means for constraining a rumen drug delivery device in a rolled configuration, said means comprising a laminate, which may be perforated, comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water-dispersible pressure sensitive adhesive to a repulpable tape, said tape having said water-dispersible pressure sensitive adhesive on both its surfaces; a laminate comprising a flexible, water-permeable polymeric material bonded between the low friction surface material and the repulpable tape; and devices constrained by said means.

Abstract: Certain N-(substituted)-1-heteroaryl-oxindole-3-carboxamides wherein the N-substituent is thienyl, furyl, phenyl or substituted phenyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflammatory agents in mammals.

Abstract: A pharmaceutical preparation for parenteral administration of a drug consisting of a solvent system containing:(a) 0 to 65% by weight of .alpha.-tetrahydrofurfuryl-.omega.-hydroxy-polyloxyethylene;(b) 10 to 100% by weight polyethylene glycol with a mean molecular weight of 200 to 600; and(c) 0 to 35% by weight of waterThe sum of components (a) and (b) amounting to at least 65% by weight, and one or more therapeutically active compounds of the formula ##STR1## wherein R.sub.1 denotes a phenyl radical optionally substituted with 1 to 3 substituents independently selected from the group consisting of F, Cl, Br, I, CF.sub.3, C.sub.1 to C.sub.4 alkyl, and C.sub.1 to C.sub.4 alkoxy, or 5-chloro-pyrid-2-yl; X denotes OH, F, Cl or Br; R.sub.2 is H, CH.sub.3 or F; and R.sub.3 is H or F.

Abstract: Certain 1-heteroaryl-3-acyl-2-oxindoles wherein the acyl-substituent is thenoyl, furoyl, benzoyl or substituted benzoyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflammatory agents in mammals.

Abstract: A verification system for detecting the presence and absence of an object includes a verification station. A preselected number of objects is delivered to the verification station with each object disposed at a selected position. A pneumatic comparator is located at each selected position. Each pneumatic comparator comprises a head directed toward its corresponding selected position. The head includes an exit port and an entry port whereby air may be discharged through the exit port and directed toward the selected position. If an object is located at the selected position the air is reflected back into the entry port where it is sensed to indicate the presence of the object.

Abstract: An oral drug delivery system having delayed gastrointestinal transit comprising a non-continuous compressible element and an attached controlled release device and which in the expanded form resists gastrointestinal transit; and a modular system for use therein comprising a non-continuous compressible element and an attached receptacle means for receiving and holding a drug-containing orally administrable controlled release device and which in the expanded form resists gastric transit.