Patents Represented by Attorney Gwilym J.O. Attwell

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  • Oxazolidinone photoaffinity probes
    Patent number: 6858635
    Abstract: Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.
    Type: Grant
    Filed: February 6, 2003
    Date of Patent: February 22, 2005
    Assignee: Pharmacia & Upjohn Company
    Inventors: Lisa Marie Thomasco, Robert C. Gadwood
  • Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
    Patent number: 6835546
    Abstract: The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: December 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: David E. Lowery, Valdin G. Smith, Teresa M. Kubiak, Martha J. Larsen
  • Human RNase III and compositions and uses thereof
    Patent number: 6737512
    Abstract: The present invention provides polynucleotides encoding human RNAse III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: May 18, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Hongjiang Wu, Stanley T. Crooke
  • Matrix metalloproteinases
    Patent number: 6734005
    Abstract: The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: May 11, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Timothy Wood, Jonas Ekblom, Erik Holmgren, Mats Kihlén
  • HCV NS3 protein fragments having helicase activity and improved solubility
    Patent number: 6472180
    Abstract: The Hepatitis C Virus (HCV) NS3 protein contains amino acid motifs of a serine proteinase, a nucleotide triphosphatase (NTPase), and an RNA helicase. A carboxy fragment of the HCV NS3 protein was purified and possessed RNA helicase activity. Detections from the amino terminus resulted in the protein becoming soluble. Deletions from the carboxy terminus do not result in a loss of helicase activity until at least 50 amino acids are deleted. The helicase activity requires ATP and divalent cations such as Mg2+ and Mn2+. The helicase activity was blocked by monoclonal antibody specific to the HCV NS3 protein.
    Type: Grant
    Filed: January 15, 2000
    Date of Patent: October 29, 2002
    Assignee: Chiron Corporation
    Inventors: Michael Houghton, Qui-Lim Choo, Jang Han, Joonho Choe
  • Conjugates formed from heat shock proteins and oligo-or polysaccharides
    Patent number: 6403099
    Abstract: The present invention provides conjugate compounds comprising at least one heat shock protein or portion thereof including at least one immunostimulatory domain and at least one capsular oligosaccharide or polysaccharide of a pathogenic bacteria. The compound comprises oligosaccharides of the Meningococci C (MenC) group and a heat shock protein selected from M. bovis BCG GroE1-type 65 kDa hsp (hspR65), recombinant M. tuberculosis DnaK-type 70 kDa hsp (hspR70) and a heat shock protein from H. pylori. The invention also provides processes for producing conjugate compounds, pharmaceutical compositions comprising conjugate compounds, therapeutic compositions comprising conjugate compounds, and methods of inducing an immune response.
    Type: Grant
    Filed: November 1, 1994
    Date of Patent: June 11, 2002
    Assignee: Chiron S.p.A.
    Inventors: Rino Rappuoli, Paolo Costantino, Stefano Viti, Francesco Norelli
  • HCV genomic sequences for diagnostics and therapeutics
    Patent number: 6297370
    Abstract: The present application features nucleic acid, peptide and antibody compositions relating to genotypes of hepatitis C virus and methods of using such compositions for diagnostic and therapeutic purposes.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: October 2, 2001
    Assignee: Chiron Corporation
    Inventors: Tai-An Cha, Eileen Beall, Bruce Irvine, Janice Kolberg, Michael S. Urdea