Abstract: 2-Ketoalkyl-4(3H)-quinazolinones of the formula ##STR1## wherein R.sub.1 is an aliphatic, cycloaliphatic or hydrocarbon aromatic group of 1-10 carbon atoms;A is divalent alkylene of 1 to 10 carbon atoms;R.sub.2 is an aliphatic, cycloaliphatic, hydrocarbon aromatic or heterocyclic group of 1-10 carbon atoms formed by condensing an acyl ester of the formula R.sub.2 COOR' which can be dissociated to form --COR.sub.2 and R'OH in which R' is the alcoholic portion of said ester; andR.sub.3 and R.sub.4 are each hydrogen, hydroxy, amino, halogen, trifluoromethyl, alkyl, alkoxy, alkylthio or alkylsulfonyl each of 1-4 carbon atoms, the substituents other than hydrogen when present being preferably in the 6- and/or 7-position of the quinazolinone nucleusprovide compounds having useful activity as CNS depressants and anticonvulsants.

Abstract: In a spool-sleeve type change-over valve, the axial width of the intake passage is reduced relative to that of the discharge passage within a range in which the same cylinder response as attained by intake and discharge passages of the same axial width is retained.

Abstract: .gamma.-lactones are converted into both known and new azetidine carboxylic acids which can be transformed readily to the corresponding .beta.-lactams by oxidative decarboxylation. The .beta.-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams such as nocardicin.

Abstract: An optical quality glass composition suitable for the production of optical elements with a refractive index gradient delta n of at least 100.times.10.sup.-4 by utilizing an ion exchange, consisting essentially of the following synthesis composition, in % by weight:______________________________________ SiO.sub.2 56-78 MgO 6-15 Li.sub.2 O 5-14 Na.sub.2 O 3-14 K.sub.2 O 0- 9 ______________________________________wherein the total of MgO plus Li.sub.2 O is 12-23.

Abstract: Synthetic suede leather is produced by casting a mixture containing polyurethane elastomer and a solvent therefor between two sheets of a substrate fabric, immersing the resulting structure in a liquid which is a nonsolvent for polyurethane elastomer but miscible with said solvent, splitting said structure into two sheets at middle of the cast layer before it is fully gelled, and re-immersing the resultant sheets in said nonsolvent to allow complete gelation of said mixture.

Abstract: Novel derivatives of kanamycin, 1-N-(L-4-amino-2-hydroxy butyryl)-6'-N-alkylkanamycins, have been prepared which possess improved antibacterial activity against gram-positive and gram-negative bacteria including kanamycin-resistant strains.

Abstract: A new 1-N-(.omega.-aminoalkanesulfonyl) derivative of an aminoglycosidic antibiotic such as ribostamycin, 3'-deoxy- or 3',4'-dideoxy-ribostamycin, kanamycin A or B, and 3'-deoxy- or 3',4'-dideoxy-kanamycin B exhibits a broader, antibacterial spectrum than the parent aminoglycosidic antibiotic and is useful in the therapeutic treatment of infections caused by gram-positive and gram-negative bacteria including drug-resistant strains thereof. The aforesaid derivative may be made by reaction between the parent antibiotic and an amino-protected .omega.-aminoalkanesulfonic acid halide and removal of the amino-protecting group from the condensation product.

Abstract: A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomyces toyocaensis SF-1771, in a liquid culture medium under aerobic conditions. This antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing antibiotic which shows antibacterial activity against Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a toxicity lower than SF-1771 substance.

Abstract: 1,2,3,4,5,6-Hexahydro-1,6-methano-3-benzazocines and derivatives thereof are described together with intermediates and methods for their preparation and pharmaceutical compositions and methods for the use thereof. Representative compounds of this new ring system exhibit useful analgesic activity without either physical dependence liability or narcotic antagonist properties.

Abstract: Thin-walled, light glass containers formed by the press and blow process may be strengthened by(1) exposing the internal surface of said containers to the action of an agent capable of decreasing the amount of extractable alkali from said surface at an elevated temperature immediately after the blowing process but before the annealing process;(2) passing the containers through the annealing station; and(3) subjecting the external and internal surfaces of said glass containers to a treatment of exchanging sodium ions in the surface portion with potassium ions to form a compressive stress layer in said surface portion.

Abstract: Azetidine-2-carboxylic acids are transformed readily to the corresponding beta-lactams by iminium salt formation and reaction of the salt with a suitable nucleophile. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams such as nocardicin.

Abstract: Polyimides of the formula ##STR1## Methods of making and polymerizing precursors for such polymers. Coating and adhesive compositions including constituents which can be converted into polyimides with the foregoing structure. Methods of making and using the compositions. Adhesion promoters for such compositions which are reaction products of aromatic dianhydrides and cyclic oxoimines, and methods of producing and using the adhesion promoters.

Abstract: A method of constructing an orthodontic appliance to be placed in a patient's mouth so as to effect desired tooth repositioning which includes the steps of initially making an impression of the patient's malocclusion and repositioning the teeth of the model so as to form an ideal model. A template is fabricated in accordance with the ideal model to properly position orthodontic brackets upon the ideal model so as to, in effect, ideally position the brackets relative to the teeth of the ideal model as well as with respect to each other. The brackets are then transferred from the ideal model to the patient's teeth with the aid of a transfer registration mold. The template is also used to guide fabrication of ideal arch wires which are to be selectively secured to the brackets at various stages of orthodontic treatment.

Abstract: New antibiotics SF-1130-x.sub.1 substance and SF-1130-x.sub.2 substance are produced by cultivating a microorganism Streptomyces myxogenes SF-1130 now deposited under FERM-P. 676 and ATCC. 31305 in a liquid culture medium under aerobic conditions, and these antibiotics may be isolated from the fermentation broth and are useful as an activator for enhancing the host defense system in living animals. The activity of these antibiotics may be improved when used in combination with one or more of maltose, maltotriose, maltotetraose, maltopentaose, maltohexaose and maltoheptaose.

Abstract: A steel concrete container with a roof formed as a suspended shell comprising sector-shaped precast, prestressed concrete elements and a reinforced concrete topping.

Abstract: Green beany flavors and odors characteristic of soybean can be removed to a satisfactory extent from a textured soy protein by a method comprising (i) the first step of treatment wherein the soy protein is retained at a temperature of from 80.degree. to 145.degree. C. for a suitable period of time while the water content of said soy protein is maintained at a predetermined value, and (ii) the second step of treatment wherein said moistened soy protein treated in the first step is kept in contact with a flow of superheated steam at a temperature of from 105.degree. to 160.degree. C.

Abstract: Maltopentaose and maltohexaose are produced with commercial advantage by cultivation of Streptomyces myxogenes SF-1130 strain under aerobic conditions in an appropriate culture medium and recovery from the resultant culture.

Abstract: A known nucleoside, coformycin and its related substances such as isocoformycin, 2'-deoxycoformycin and formycins present as a mixture of them may be separated from each other when an aqueous solution containing them is chromatographed on a column of a cation-exchanger having partially activated carboxylic groups as the ion-exchange function with using water or a buffer solution as the developing solvent.

Abstract: There is described a solenoid pilot operated change-over valve of the type using a spool/piston assembly which is movable in response to pressure prevailing in a pilot chamber, wherein the effective diameter of a drain valve seat in the pilot chamber is formed at least 1.4 times greater than that of a pilot valve seat on the piston through which the pilot chamber is communicable with an input port of the valve. The spool/piston assembly is reset to the initial position upon de-energization of the solenoid before the pilot valve seat is completely closed by a plunger.

Abstract: An osteotome includes an arcuate cutting blade portion and a planar cutting blade portion integrally secured thereto. The arcuate portion is defined from a locus of a perfect circle and is axially elongated relative to the planar blade so as to permit the arcuate blade to be reained within an initially cut portion of a bone while the entire osteotome is rotated to a new, second position in order to perform a second cutting of the bone. The two cuttings of the bone serve to remove a section of the original bone, and in this manner, when the bone sections are repositioned relative to one another, the same will be precisely aligned so as to correct the original bone deformity.