Abstract: A pipe joint having a radially displaceable clamp ring located within a cylindrical joint casing to circumvent a pipe passage along which a pipe is to be inserted, the clamp ring being movable between an inner concentric position and an outer eccentric position and provided with a sharp edge around the inner periphery thereof. Upon inserting a pipe into the joint casing, the clamp ring is pushed into the inner concentric position to allow passage of the pipe and, as soon as the pipe is fully inserted into a connected position, the clamp ring is pressed toward the outer eccentric position by a spring, clamping the pipe securely in the connected position by the sharp edge on the inner periphery of the ring.

Abstract: Nucleotides of nucleosides or bases having known cytotoxic activity are reacted with steroids, preferably corticosteroids, to form corresponding cytotoxic nucleoside-corticosteroid phosphodiester analogues of the formula: ##STR1## wherein: steroid is the residue formed by removal of a hydroxyl hydrogen atom from a natural or synthetic adrenal corticosteroid containing the characteristic cyclopentanophenanthrene nucleus which is esterified to the phosphate moiety at the 21-position;sugar is a naturally occurring pentose or deoxypentose in the furanose form, preferably ribose, deoxyribose, lyxose, xylose or arabinose and especially ribose, deoxyribose or arabinose, which is esterified to the phosphate moiety at the 5'-position and covalently bonded to the heterocycle moiety at the 1'-position to form a nucleoside; andheterocycle is a purine, pyrimidine, hydrogenated pyrimidine, triazolopurine or similar nucleoside base.