Patents Represented by Attorney Hal B. Woodrow
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Patent number: 8084490Abstract: The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.Type: GrantFiled: June 16, 2005Date of Patent: December 27, 2011Assignee: Janssen Pharmaceutica N.V.Inventors: David F. McComsey, Michael H. Parker, Allen B. Reitz, Bruce E. Maryanoff
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Patent number: 8076358Abstract: The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of ?-secretase, also known as ?-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.Type: GrantFiled: January 27, 2009Date of Patent: December 13, 2011Assignee: Janssen Pharmaceutica NVInventors: Ellen Baxter, Christopher J. Creighton, Tianbao Lu, Allen B. Reitz, Charles H. Reynolds, Tina Morgan Ross, Ellen Sieber-McMaster
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Patent number: 7091378Abstract: The present invention provides a novel method for the formation of hydroxamic acids comprising reacting under suitable conditions an ester with hydroxylamine in the presence of cyanide anion.Type: GrantFiled: July 6, 2004Date of Patent: August 15, 2006Assignee: Janssen Pharmaceutica, N.V.Inventors: Chih Yung Ho, Eric David Strobel
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Patent number: 7081463Abstract: The present invention is directed to novel hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, panic, dementia, mania, bipolar disorder, substance abuse, neuropathic pain, acute pain, chronic pain, migraine, asthma, cough, psychosis, schizophrenia, epilepsy, hypertension, obesity, eating disorders, cravings, diabetes, cardiac arrhythmia, irritable bowel syndrome, Crohn's disease, urinary incontinence, adrenal disorders, attention deficit disorder (ADD), attention deficit hyperactivity disorder (ADHD), Alzheimer's disease, for improved cognition or memory and for mood stabilization.Type: GrantFiled: September 5, 2003Date of Patent: July 25, 2006Assignee: Janssen Pharmaceutica N.V.Inventors: Kathleen Battista, Gilles Bignan, Peter J. Connolly, Allen B. Reitz, Tina Morgan Ross, Malcolm Scott, Steven A. Middleton, Michael Orsini
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Patent number: 7081460Abstract: The invention is directed to novel quinazoline and quinazoline-like derivatives of Formula (I): useful as integrin antagonists and methods for the treatment of integrin-mediated disorders.Type: GrantFiled: April 5, 2002Date of Patent: July 25, 2006Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: William J. Hoekstra, Edward C. Lawson, Michael J. Costanzo
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Patent number: 7053101Abstract: The present invention is directed to novel 1,3,8-triazaspiro[4.5]decan-4-one derivatives of the general formula wherein all variables are as defined herein, useful in the treatment of disorders and conditions mediated by the ORL-1 G-protein coupled receptor. More particularly, the compounds of the present invention are useful in the treatment of disorders and conditions such as anxiety, depression, substance abuse, neuropathic pain, acute pain, migraine, asthma, cough and for improved cognition.Type: GrantFiled: August 2, 2004Date of Patent: May 30, 2006Inventors: Alfonzo Jordan, Allen B. Reitz, Kevin Pan
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Patent number: 6849643Abstract: The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.Type: GrantFiled: December 6, 2001Date of Patent: February 1, 2005Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Han-Cheng Zhang, Bruce Maryanoff, Bruce Conway, Kimberly White, Hong Ye, Leonard Robert Hecker, David F. McComsey
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Patent number: 6713475Abstract: The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.Type: GrantFiled: July 24, 2001Date of Patent: March 30, 2004Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: William J. Hoekstra, Alexey B. Dyatkin, Bruce E. Maryanoff, Jay M. Matthews
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Patent number: 6710061Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.Type: GrantFiled: November 25, 2002Date of Patent: March 23, 2004Assignee: Ortho-McNeil Pharamceutical, Inc.Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
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Patent number: 6630505Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.Type: GrantFiled: November 25, 2002Date of Patent: October 7, 2003Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Michael N. Greco, Bruce E. Maryanoff, Michael J. Hawkins, Robert E. Boyd
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Patent number: 6365617Abstract: The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.Type: GrantFiled: June 26, 2000Date of Patent: April 2, 2002Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: David F. McComsey, William J. Hoekstra, Bruce E. Maryanoff, Han-Cheng Zhang
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Patent number: 5728752Abstract: The present invention provides injectable, bioabsorbable microdispersions suitable for use as a soft tissue repair or augmentation material in animals comprising a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers of a plurality of at least two different first lactone repeating units and other liquid polymers; and a particulate material. Additionally, the present invention also discloses methods of using these microdispersions for tissue augmentation and repair as well as kits which include prefilled containers to facilitate the use of these materials.Type: GrantFiled: March 15, 1996Date of Patent: March 17, 1998Assignee: Ethicon, Inc.Inventors: Angelo G. Scopelianos, Steven C. Arnold, Rao S. Bezwada, Mark B. Roller, Shawn T. Huxel
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Patent number: 5700583Abstract: The present invention describes a crosslinked aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The crosslinked aliphatic polyoxaesters of the present invention is formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:?O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- !Iand a second repeating unit of the formula:?--O--R.sub.12 --!.sub.U, XVIand optionally a third repeating unit with a formula selected from the group consisting of:?--O--R.sub.4 --!.sub.A, II?--O--R.sub.5 --C(O)--!.sub.B, III(?--O--R.sub.5 --C(O)!.sub.P --O--).sub.L G XIand combinations thereof wherein R.sub.12 contains an internal amine or internal amide group wherein the aliphatic polyoxaester has been crosslinked.Type: GrantFiled: November 6, 1996Date of Patent: December 23, 1997Assignee: Ethicon, Inc.Inventors: Dennis D. Jamiolkowski, Rao S. Bezwada
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Patent number: 5442033Abstract: A copolymer of from in the range of from about 55 to about 70 weight percent lactide and from in the range of from about 45 to about 30 mole percent .epsilon.-caprolactone suitable for use in biomedical applications such as drug delivery, coatings for surgical sutures and needles, and lubricants for medical devices.Type: GrantFiled: November 14, 1994Date of Patent: August 15, 1995Assignee: Ethicon, Inc.Inventor: Rao S. Bezwada
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Patent number: 5321113Abstract: A copolymer of an aromatic anhydride and an aliphatic ester suitable for use in surgical devices and a process for making said copolymer.Type: GrantFiled: May 14, 1993Date of Patent: June 14, 1994Assignee: Ethicon, Inc.Inventors: Kevin L. Cooper, Angelo G. Scopelianos
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Patent number: 4838948Abstract: The present invention pertains to a process for cleaning polymeric processing equipment. The process comprises purging the polymer processing equipment with a composition comprising a polymer, a mild abrasive and a sulfonated surfactant.Type: GrantFiled: July 27, 1987Date of Patent: June 13, 1989Assignee: Phillips Petroleum CompanyInventor: Fay W. Bailey
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Patent number: 4837358Abstract: Process for the production of 9-alkenyl acetates is provided. The process comprises first disproportionating cyclooctene with an .alpha.-olefin to give a 1,9-alkadiene. The alkadiene is metallated to form a 1-metallo-9-alkene, which is then contacted with oxygen to produce a 9-alkenyl-1-oxymetallo compound, which is optionally hydrolyzed to the corresponding alcohol, with the alcohol being esterified to the desired 9-alkenyl ester or the 9-alkenyl-1-oxymetallo compound can be directly esterified, to produce the desired 9-alkenyl esters.Type: GrantFiled: February 26, 1986Date of Patent: June 6, 1989Assignee: Phillips Petroleum CompanyInventors: Jim D. Byers, Charles A. Drake
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Patent number: RE39181Abstract: The present invention is concerned with physicochemically stable aqueous solutions of risperidone for oral and parenteral administration; processes for preparing such formulations.Type: GrantFiled: December 4, 2001Date of Patent: July 11, 2006Inventors: Marc Karel Jozef François, Willy Maria Albert Carlo Dries