Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.

Abstract: The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.

Abstract: The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.

Abstract: The invention is directed to novel triazolopyridine derivatives which are useful as antagonists of GPIIb/IIIa. Pharmaceutical compositions comprising the triazolopyridine derivatives of the present invention, methods of treating conditions mediated by GPIIb/IIIa (e.g., methods for treating platelet-mediated thrombotic disorders) along with processes for making the compounds and novel intermediates are also disclosed.

Abstract: An absorbable biocompatible polymeric plate is described. The plate has channels on its top surface and through its thickness for receiving sutures to secure soft tissue proximally to the device. The plate also has notches on its bottom surface for added security of soft tissue when conditions require the surgeon to attach tissue beneath the plate.

Abstract: A sterile one-piece suture clip having a first clamping member having a distal end, a first proximal end and a first clamping surface, a second clamping member having a second proximal end, a second clamping surface, and a locking surface and being pivotally connected at said second proximal end by a hinge to said first proximal end of the first clamping member, a plurality of leg members each having an inner surface, a side surface and an end, said legs being disposed in sets comprising U-shaped members in combination with the first clamping surface, the inner surface of each leg in the set facing the opposite leg thereof, said inner surface being beveled from the end of the leg toward the first clamping surface to form ears, said U-shaped members being attached to the first clamping member, said side surface of said legs being beveled from the end of the leg toward the first clamping member thereby forming a channel said first clamping member being adapted to be placed on a suture to be clipped, said channe