Patents Represented by Attorney, Agent or Law Firm Hallie A. Funucane
  • Calcification-resistant biomaterials
    Patent number: 6193749
    Abstract: In general, the invention features a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structure having a quantity of calcification inhibitors releasably bound thereto. The storage structure can be a protein or a synthetic polymer. The calcification inhibitors include metal ions and phosphatase inhibitors generally. Bifunctional metal chelators can be bound to endogenous proteins to deliver metal ions.
    Type: Grant
    Filed: September 17, 1997
    Date of Patent: February 27, 2001
    Assignee: St. Jude Medical, Inc.
    Inventors: Richard F. Schroeder, Matthew F. Ogle