Abstract: A fiber grating stabilized pump laser achieves power stability with a relatively low grating reflectivity of 1.0 to 2.3%. Substantial laser diode output facet reflectivity is provided, between 3.0 and 5.5%. When the optical fiber system provides for no polarization control between the grating and the diode laser, the power reflectivity of the grating, is preferably between 1.7 and 2.3%. The power reflectivity of the laser diode output facet is preferably between 3.4 and 4.9%. In contrast, when provisions are made for polarization control between the grating and laser diode, even lower grating reflectivities are possible, between 1.0 and 2.3%.

Abstract: The composition and methods of synthesis of phosphorus prodrugs are described. These methods can be used to convert negatively charged phosphorus bearing drugs into neutrally charged; lipid soluble prodrugs which are able to passively diffuse into cells and into tissues in vivo. Prodrugs for a variety of antiviral and anti-leukemic agents are described.