Patents Represented by Law Firm Hammond & Littell
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Patent number: 4656171Abstract: Compounds of the formula ##STR1## wherein A, B, C and D are each independently --N.dbd. or --CH.dbd., provided, however, that at least two of them must be --N.dbd., and when A and C are both --N.dbd., at least one or both of B and D must be --N.dbd.; andR.sub.1, R.sub.2 and R.sub.3 are substituents of diverse types;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds are useful as cardiotonics.Type: GrantFiled: November 27, 1984Date of Patent: April 7, 1987Assignee: Dr. Karl Thomae GmbHInventors: Volkhard Austel, Norbert Hauel, Joachim Heider, Manfred Reiffen, Jacobus C. A. Van Meel, Willi Diederen
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Patent number: 4655710Abstract: The present invention relates to a method for replacing lost tooth substance wherein a model is made from an impression of a prepared tooth or teeth upon which the replacement is to be made. The model serves as a master for transferring the shape of the model to work pieces by means of mechanical processing means.Type: GrantFiled: November 26, 1984Date of Patent: April 7, 1987Inventors: Knut M. G. Andersson, Karl E. M. Andersson
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Patent number: 4654042Abstract: This invention relates to sulfonated lubricating agents for leather and furs. More specifically, this invention relates to a process for the production of sulfonated lubricating agent for leather and tanned furs consisting of the steps of:(a) sulfochlorinating higher fatty acids or esters of higher fatty acids having chain lengths of from 8 to 24 carbon atoms with chlorine and SO.sub.2 at a temperature of from about 20.degree. to 90.degree. C. under UV-radiation for a time sufficient to obtain a compound having a chlorine content of from about 5 to 30 percent by weight and a content of --SO.sub.2 Cl groups of from about 1 to 20 percent by weight, the ratio of chlorine atoms to --SO.sub.2 Cl groups being from about 0.7:1 to 70:1; and(b) forming a water-emulsifiable alkaimetal, ammonium, or lower-alkyl-ammonium salt of the compound produced in step (a).Type: GrantFiled: June 2, 1986Date of Patent: March 31, 1987Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Wolf-Dieter Willmund, Jurgen Plapper, Friedrich Pieper, Jochen Heidrich
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Patent number: 4650664Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol or its acid addition salt.Type: GrantFiled: September 3, 1985Date of Patent: March 17, 1987Assignee: Dr. Karl Thomae GmbHInventors: Gottfried Schepky, Rolf Brickl, Peter Gruber, Jochen Schmid, Ursula Springmeier
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Patent number: 4650217Abstract: A continuous strip of mutually adjacent information-bearing panels are joined together by hinge means, each of which comprises a series of hinge openings and hinge sections. The relative positions of the hinge sections and openings of one hinge means are so positioned in relation to the hinge sections and openings of a further hinge means as to enable the strip to be folded in a bundle or part bundle form, so that a selected panel can be brought to the top of the bundle or part bundle, with the hinge sections of a respective hinge means lying within the confines of the openings of the remaining hinge means.Type: GrantFiled: November 30, 1984Date of Patent: March 17, 1987Assignee: Konstruktionsatelje Ake.ANG.hrlundInventor: Ake Ehrlund
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Patent number: 4650361Abstract: A joint connection for attachment of reflector panels at a truss support structure of a radio telescope, where the bars of the truss and the reflector panels consisting of fiber composite material, and adjusting means for the reflector panels between the ball-shaped central body of the joint and the reflector panels.Type: GrantFiled: December 24, 1984Date of Patent: March 17, 1987Assignee: Dornier System GmbHInventor: Walter Seuster
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Patent number: 4649150Abstract: Compounds of the formula ##STR1## wherein R represents substituents of various types;R.sub.1 and R.sub.2 are each independently hydrogen or lower alkyl;R.sub.3 represents substituents of various types; andR.sub.4 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halogen, cyano or carbamoyl;tautomers thereof; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antiulcerogenics.Type: GrantFiled: May 16, 1984Date of Patent: March 10, 1987Assignee: Istituto de Angeli, S.p.A.Inventors: Giuseppe Bietti, Enzo Cereda, Arturo Donetti, Antonio Giachetti, Ferdinando Pagani
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Patent number: 4647563Abstract: Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R.sub.1 is H or acyl,R.sub.2 is H, R.sub.1 O, --NHSO.sub.2 R.sub.7, --NHCOR.sub.8, --NHCONHR.sub.8, --NH--CH.sub.2 --C.sub.6 H.sub.4 --R.sub.9, --CH.sub.2 OH, --CH.sub.2 SO.sub.2 R.sub.7, --CONHR.sub.8, halogen or --CN,R.sub.3 is H, halogen, R.sub.7 or --OR.sub.7,R.sub.2 and R.sub.3 together with each other are ##STR3## R.sub.4 is H, --CH.sub.3 or --C.sub.2 H.sub.5, R.sub.5 and R.sub.6 are each H or --CH.sub.3,R.sub.7 is C.sub.1 -C.sub.4 alkyl,R.sub.8 is H or C.sub.1 -C.sub.4 alkyl,R.sub.9 is H, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy optionally interrupted by oxygen,R.sub.10 and R.sub.12 are each H, CH.sub.3, Cl or OCH.sub.3, or together methylenedioxy,X is ##STR4## or N, and Z is --CH.sub.2 or --CO;in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof.Type: GrantFiled: December 9, 1985Date of Patent: March 3, 1987Assignee: Boehringer Ingelheim KGInventors: Kurt Schromm, Anton Mentrup, Ernst-Otto Renth, Armin Fugner, Ilse Streller
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Patent number: 4645841Abstract: Compounds of the tautomeric formula ##STR1## wherein R, R.sub.1 and R.sub.2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms;R.sub.3 is straight or branched alkyl, optionally interrupted by heteroatoms such as oxygen, sulfur or nitrogen; straight or branched alkenyl; alkynyl; cyano; cycloalkyl or cycloaliphatic alkyl; a bicyclic group; aryl; or a heterocyclic group; orR.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, form a heterocyclic group;R.sub.4 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; andHet is a substituted or unsubstituted heterocycle containing two or three heteroatoms; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics.Type: GrantFiled: June 24, 1985Date of Patent: February 24, 1987Assignee: Istituto de Angeli, S.p.A.Inventors: Giuseppe Bietti, Enzo Cereda, Arturo Donetti, Piero Del Soldato, Antonio Giachetti, Rosamaria Micheletti
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Patent number: 4643993Abstract: Compounds of the formula ##STR1## wherein Het is a heterocycle containing 2 to 3 nitrogen atoms;R is hydrogen, lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen;Y is --SO.sub.3 H or ##STR2## R" is alkyl of 1 to 3 carbon atoms; and R' is straight or branched alkyl which may contain a heteroatom such as sulfur, oxygen or nitrogen; straight or branched alkenyl; cycloalkyl; alkyl-cycloalkyl; aryl; or aralkyl optionally substituted by lower alkyl, alkoxy of 1 to 3 carbon atoms or halogen; tautomers thereof, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as anti-ulcerogenics and gastric acid secretion inhibitors.Type: GrantFiled: May 18, 1983Date of Patent: February 17, 1987Assignee: Istituto de Angeli S.p.A.Inventors: Enzo Cereda, Arturo Donetti, Antonio Giachetti, Piero del Soldato
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Patent number: 4639438Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 which may be identical to or different from each other, are each straight or branched alkyl of 1 to 3 carbon atoms;R.sub.3 is alkyl of 1 to 8 carbon atoms;X is sulfur or oxygen;Y is chlorine, bromine or fluorine; andn is 1 or 2.The compounds are useful as pesticides.Type: GrantFiled: March 12, 1986Date of Patent: January 27, 1987Assignee: Celamerck GmbH & Co. KGInventors: Richard Sehring, Wolfgang Buck, Ricarda Prokic-Immel, Sigmund Lust
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4-phenyl-tetrahydro-furano-pyridines and anti-depressant pharmaceutical compositions containing same
Patent number: 4636510Abstract: The invention relates to 4-phenyl-tetrahydro-furano-pyridines of the formulas ##STR1## wherein R.sup.1 to R.sup.5 are variously defined. The compounds of the invention are intended to be used as anti-depressants with, in particular, thymoleptic and central-stimulant properties.Type: GrantFiled: April 19, 1984Date of Patent: January 13, 1987Assignee: Boehringer Ingelheim KGInventors: Claus Schneider, Gerhard Walther, Karl-Heinz Weber, Wolf D. Bechtel, Karin Boke-Kuhn -
Patent number: 4629733Abstract: The present invention relates to novel indolinones of the general formula ##STR1## wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.Type: GrantFiled: July 27, 1984Date of Patent: December 16, 1986Assignee: Dr. Karl Thomae GmbHInventors: Erich Muller, Josef Nickl, Josef Roch, Berthold Narr
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Patent number: 4624960Abstract: The invention relates to the use of a substance as a sedative with an analgesic and bradycardiac effect in warm-blooded animals. The possible applications are, for example, in the field of veterinary medicine for general tranquilizing and for producing analgesia.Type: GrantFiled: October 11, 1985Date of Patent: November 25, 1986Assignee: Boehringer Ingelheim Vetmedica GmbHInventors: Otto Kern, Franz Wilhelm
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Patent number: 4622340Abstract: This invention relates to compounds of the formula ##STR1## Z' is chlorine or fluorine, with the proviso that Z' is chlorine when Q is the moiety of Formula III. The invention also relates to the preparation of the compounds, their use in controlling animal pests in plant protection, and pesticidal agents comprising the compounds as active ingredients.Type: GrantFiled: April 26, 1984Date of Patent: November 11, 1986Assignee: Celamerck GmbH & Co., KGInventors: Heinz-Manfred Becher, Ricarda Prokic-Immel, Walter Wirtz
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Patent number: 4617949Abstract: This invention relates to an apparatus for applying materials to the scalp. More specifically, this invention relates to a scalp applicator means comprising a hollow body and an applicator means, said applicator means comprising two forked prongs, each of which prongs has at its end at least one outlet or spray opening, the outlets or spray openings on each prong being positioned laterally on the sides of the prongs away from each other.Type: GrantFiled: October 11, 1984Date of Patent: October 21, 1986Assignee: Basotherm GmbHInventor: Ernest Hofmann-Igl
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Patent number: 4616018Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen; alkyl of 1 to 7 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; monosubstituted alkyl of 1 to 3 carbon atoms, where the substituent is pyridyl, methylpyridyl, phenyl, mono-, di- or trisubstituted phenyl, where the substituents on the phenyl ring, which may be identical to or different from each other, are selected from the group consisting of one amino, one dimethylamino, one to two hydroxyls, one to three methoxys and one to three halogens; .omega.-monosubstituted alkyl of 2 to 4 carbon atoms, where the substituent is hydroxyl or di(alkyl of 1 to 3 carbon atoms)amino; phenyl; monohalo-phenyl; unsubstituted or monosubstituted straight or branched alkanoyl of 1 to 6 carbon atoms, where the substituent is phenyl, methoxyphenyl or cycloalkyl of 3 to 7 carbon atoms; or unsubstituted or monosubstituted phenylsulfonyl, where the substituent is methyl or methoxy; and,R.sub.Type: GrantFiled: June 27, 1985Date of Patent: October 7, 1986Assignee: Karl Thomae GmbHInventors: Norbert Hauel, Volkhard Austel, Joachim Heider, Manfred Reiffen, Willi Diederen, Walter Haarman
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Patent number: 4616011Abstract: This invention relates to novel indole derivatives of the formula ##STR1## wherein A represents a --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## group and B represents a methylene, carbonyl, or thiocarbonyl group or A represents a --CO--CO-- or ##STR3## group and B represents a methylene group, E represents an alkylene group or a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene, or 3-hydroxy-n-butylene group,G represents an alkylene group,R.sub.1 represents a hydrogen, chlorine, or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxyl, alkoxy, or phenylalkoxy group,R.sub.2 represents a hydrogen, chlorine, or bromine atom or a hydroxyl, alkoxy, phenylalkoxy, or alkyl group orR.sub.1 and R.sub.2 together represent an alkylenedioxy group,R.sub.3 represents a hydrogen, chlorine, or bromine atom or an alkyl group,R.sub.4 represents a hydrogen atom or an alkyl or phenylalkyl group,R.sub.Type: GrantFiled: November 26, 1984Date of Patent: October 7, 1986Assignee: Dr. Karl Thomae GmbHInventors: Manfred Reiffen, Joachim Heider, Volkhard Austel, Norbert Hauel, Walter Kobinger, Christian Lillie
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Patent number: 4613325Abstract: A flow rate sensing device, particularly for use in regulating the rate of flow in a system for parenteral administration of liquids to patients. The liquid emerges from a storage reservoir and is fed into a housing through an upstream flow passage portion and then is made to pass through a narrow throat passage wherein the velocity of the liquid increases while its pressure decreases. The liquid then emerges into a downstream flow through passage and flows through an outlet from the housing. In an intravenous fluid administration system, the housing outlet is connected to a terminal tubing section and an intravenous needle. A pressure transducer, consisting of two chambers separated by a resilient deformable diaphragm, has its upstream chamber in fluid and pressure communication with the upstream flow path portion and its downstream chamber in fluid and pressure communication with the flow emerging from the throat passage.Type: GrantFiled: December 22, 1983Date of Patent: September 23, 1986Inventor: Lawrence M. Abrams
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Patent number: 4609672Abstract: The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; andR.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.Type: GrantFiled: June 25, 1984Date of Patent: September 2, 1986Assignee: C. H. Boehringer SohnInventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker