Abstract: A novel and improved drug-free treatment for alopecia, headache and other stress-induced diseases by stimulation using alternatively ambient and negative pressures. The treatment promotes hair growth by inducing alternatively an ambient pressure and a negative pressure stimulation to the bald or balding scalp. The treatment administered for several minutes daily for several weeks results in restoration of the hair growth, in the prevention of the hair loss and in the reduction of headaches.

Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein:n is an integer equal to 0, 1, 2 or 3;R.sup.1 is hydrogen, lower alkyl, optionally substituted phenyl or optionally substituted phenyl lower alkyl;each R is independently hydrogen, lower alkyl, optionally substituted phenyl, or optionally substituted phenyl lower alkyl;are .alpha..sub.2 blockers, and, therefore, are useful in treating essential hypertension and depression, and in inhibiting platelet aggregation.