Abstract: A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.
Type:
Grant
Filed:
December 23, 1997
Date of Patent:
March 28, 2000
Assignee:
The Regents of the University of California
Abstract: A method for detecting and isolating a target sequence in a sample of nucleic acids is provided using a bifunctional hybridization probe capable of hybridizing to the target sequence that includes a detectable marker and a first complexing agent capable of forming a binding pair with a second complexing agent. A kit is also provided for detecting a target sequence in a sample of nucleic acids using a bifunctional hybridization probe according to this method.
Type:
Grant
Filed:
August 9, 1995
Date of Patent:
February 22, 2000
Assignee:
The Regents of the University of California
Inventors:
Joe N. Lucas, Tore Straume, Kenneth T. Bogen