Patents Represented by Attorney Harry E. Westlake
  • Patent number: 4474781
    Abstract: Substituted aminoalkoxypyridines of the formula ##STR1## where R.sub.1 is CN or CF.sub.3 and L is dialkylamino or six-membered N heterocycle are disclosed. The compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Patent number: 4429042
    Abstract: Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have significant parasiticidal activity. The compounds may be included in compositions for the oral or parenteral administration to animals for the prevention and cure of parasitic infections.
    Type: Grant
    Filed: December 30, 1981
    Date of Patent: January 31, 1984
    Assignee: Merck & Co., Inc.
    Inventors: George Albers-Schonberg, Hyman Wallick, Robert E. Ormond, Thomas W. Miller, Richard W. Burg
  • Patent number: 4374140
    Abstract: The present application discloses certain 2-substituted propoxy-3-cyano-5-hydroxypyridines. The compounds have pharmaceutical activity e.g. as antihypertensives.
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: February 15, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello, Stanley Vickers, Alfred Steuerwald
  • Patent number: 4347374
    Abstract: A process for resolving a mixture of .alpha.-fluoromethylhistidine enantiomers is described. The process features use of an ester derivative of .alpha.-fluoromethylhistidine. Novel diastereoisomer salts of said derivative are also disclosed.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: August 31, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Janos Kollonitsch, Leroy M. Perkins, George A. Doldouras, Stephen Marburg
  • Patent number: 4347375
    Abstract: A process for preparing .alpha.-amino acids or ester thereof having an .alpha.-vinyl substituent and certain intermediates are disclosed.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: August 31, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee
  • Patent number: 4346042
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: August 24, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Patent number: 4336261
    Abstract: Aryloxypropanolamines, their preparation and use as pharmaceuticals is disclosed.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: June 22, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Patent number: 4336257
    Abstract: Novel alkylsubstituted 2-pyridylimidazoles, halosubstituted-2-pyridylbenzimidazoles, and 2-pyridylimidazopyridines are disclosed. The compounds have pharmaceutical utility as xanthine oxidase inhibitors and/or as antihypertensives.
    Type: Grant
    Filed: August 8, 1980
    Date of Patent: June 22, 1982
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Patent number: 4329351
    Abstract: The present application discloses 2-substituted propoxy-3-cyano-5-RO-pyridines and intermediates therefor. The former compounds have pharmaceutical activity.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4328335
    Abstract: The C-076 compounds are a series of four pairs of macrolides in which the members of each pair are homologous. The instant processes convert the C-076 A2 and B2 compounds isolated from a fermentation broth into the biologically preferred B1 and A1 compounds or into the dihydro derivatives thereof.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: May 4, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Helmut H. Mrozik
  • Patent number: 4321274
    Abstract: Substituted-1-(cinnamylideneamino)-3-benzylideneaminoguanidines, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.
    Type: Grant
    Filed: October 6, 1980
    Date of Patent: March 23, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Ching C. Wang, Michael H. Fisher
  • Patent number: 4321267
    Abstract: 1-Substituted-4(1H)-pyridinone hydrazones, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.
    Type: Grant
    Filed: October 6, 1980
    Date of Patent: March 23, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Ching C. Wang, Michael H. Fisher
  • Patent number: 4321264
    Abstract: The application discloses a pharmaceutical composition for treating hypertension containing (A) L-.alpha.-methyl-3,4-dihydroxyphenylalanine and (B) salicylamide, phenylglyoxal or L-ascorbic acid.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: March 23, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Stanley Vickers
  • Patent number: 4320129
    Abstract: Complexes of pyromellitic diimide compounds which are ruminant feed additives and which improve feed efficiency are disclosed. The pyromellitic diimide compounds may be unsubstituted pyromellitic diimide itself, or one of the nitrogen atoms may be substituted with an alkyl or substituted alkyl group. The pyromellitic diimide nucleus may also be substituted. The pyromellitic diimide compound is complexed with a compound containing an amide, amidine or thioamide linkage. The complexing agent may be either cyclic or open chain. Compositions using the complexes as ruminant feed additives are also disclosed.
    Type: Grant
    Filed: February 5, 1979
    Date of Patent: March 16, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Michael H. Fisher, Bruce O. Linn
  • Patent number: 4317530
    Abstract: Disclosed is an improved piston operated pump for viscous materials wherein the entrapment of air bubbles in the viscous material is reduced by placing a spring in the pump cylinder. The spring is the same diameter as the pump cylinder and is about as long as the length of travel of the piston. The spring is conical in shape so that it may be fully compressed without substantially affecting the capacity of the pump cylinder or the length of the piston stroke.
    Type: Grant
    Filed: December 31, 1979
    Date of Patent: March 2, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Joseph M. Magrath
  • Patent number: 4311709
    Abstract: Loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity. One particular compound, 1-amino-3-{{3-[4-(1-methylethyl)-phenyl]-1-{2-[4-(methylethyl)-phenyl]ethy l}propyl}amino}-2-propanol, and salts thereof is particularly useful as an udder wash and teat dip for mastitis prevention in lactating cows. Compositions for such use are disclosed.
    Type: Grant
    Filed: December 26, 1979
    Date of Patent: January 19, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4310541
    Abstract: Benzylidene aminoguanidene derivatives, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.
    Type: Grant
    Filed: September 22, 1980
    Date of Patent: January 12, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Ching C. Wang, Nancy J. Dick
  • Patent number: 4310519
    Abstract: Novel compounds are produced by the fermentation of a nutrient medium with the previously undescribed microorganism Streptomyces avermitilis. They may be isolated by solvent extraction and chromatographic fractionation techniques. The compounds, which are described generically as C-076 have significant parasiticidal activity. The compounds may be included in compositions for the oral or parenteral administration to animals for the treatment of parasitic infections.
    Type: Grant
    Filed: September 8, 1978
    Date of Patent: January 12, 1982
    Assignee: Merck & Co., Inc.
    Inventors: George Albers-Schonberg, Hyman Wallick, Robert E. Ormond, Thomas W. Miller, Richard W. Burg
  • Patent number: 4310518
    Abstract: Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method.
    Type: Grant
    Filed: October 1, 1980
    Date of Patent: January 12, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Daniel F. Veber
  • Patent number: RE31429
    Abstract: 9-(Dihalobenzyl)adenines are prepared uncontaminated with other positional isomers in a series of mild transformations starting from 4,5,6-triaminopyrimidine and proceeding via 7-(N-formyl-N-dihalobenzyl)amino[1,2,5]-thiadiazolo[3,4-d]pyrimidine. The resulting compounds have anticoccidial activity and are useful in controlling cecal and/or intestinal coccidiosis when administered in minor quantities to animals, in particular to poultry usually in admixture with animal sustenance.
    Type: Grant
    Filed: October 23, 1979
    Date of Patent: October 25, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Robert Tull, deceased, George D. Hartman, Leonard M. Weinstock