Patents Represented by Attorney Harry E. Westlake, Jr.

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  • Treating hypertension with aminoalkoxypyridines
    Patent number: 4474781
    Abstract: Substituted aminoalkoxypyridines of the formula ##STR1## where R.sub.1 is CN or CF.sub.3 and L is dialkylamino or six-membered N heterocycle are disclosed. The compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: October 2, 1984
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • 2-Substituted propoxy-3-cyano-5-hydroxypyridines and use as antihypertensives
    Patent number: 4374140
    Abstract: The present application discloses certain 2-substituted propoxy-3-cyano-5-hydroxypyridines. The compounds have pharmaceutical activity e.g. as antihypertensives.
    Type: Grant
    Filed: February 10, 1981
    Date of Patent: February 15, 1983
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello, Stanley Vickers, Alfred Steuerwald
  • Process for preparing amino acids and esters
    Patent number: 4347375
    Abstract: A process for preparing .alpha.-amino acids or ester thereof having an .alpha.-vinyl substituent and certain intermediates are disclosed.
    Type: Grant
    Filed: December 3, 1980
    Date of Patent: August 31, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee
  • Acid addition salts of N-trityl-.alpha.-fluoromethylhistidine enantiomer derivatives
    Patent number: 4347374
    Abstract: A process for resolving a mixture of .alpha.-fluoromethylhistidine enantiomers is described. The process features use of an ester derivative of .alpha.-fluoromethylhistidine. Novel diastereoisomer salts of said derivative are also disclosed.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: August 31, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Janos Kollonitsch, Leroy M. Perkins, George A. Doldouras, Stephen Marburg
  • Preparation of epihalohydrin enantiomers
    Patent number: 4346042
    Abstract: Processes for preparing (S) or (R) epihalohydrin and an (S) substituted glycerol intermediate are disclosed.
    Type: Grant
    Filed: May 5, 1980
    Date of Patent: August 24, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • Novel 2-pyridylbenzimidazole compounds
    Patent number: 4336257
    Abstract: Novel alkylsubstituted 2-pyridylimidazoles, halosubstituted-2-pyridylbenzimidazoles, and 2-pyridylimidazopyridines are disclosed. The compounds have pharmaceutical utility as xanthine oxidase inhibitors and/or as antihypertensives.
    Type: Grant
    Filed: August 8, 1980
    Date of Patent: June 22, 1982
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Aryloxypropanolamines
    Patent number: 4336261
    Abstract: Aryloxypropanolamines, their preparation and use as pharmaceuticals is disclosed.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: June 22, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, David E. McClure
  • 2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates
    Patent number: 4329351
    Abstract: The present application discloses 2-substituted propoxy-3-cyano-5-RO-pyridines and intermediates therefor. The former compounds have pharmaceutical activity.
    Type: Grant
    Filed: October 1, 1979
    Date of Patent: May 11, 1982
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • .alpha.-methyldopa compositions
    Patent number: 4321264
    Abstract: The application discloses a pharmaceutical composition for treating hypertension containing (A) L-.alpha.-methyl-3,4-dihydroxyphenylalanine and (B) salicylamide, phenylglyoxal or L-ascorbic acid.
    Type: Grant
    Filed: April 14, 1980
    Date of Patent: March 23, 1982
    Assignee: Merck & Co., Inc.
    Inventor: Stanley Vickers
  • Process for producing 2-bromo-3,5-disubstituted pyridines
    Patent number: 4294969
    Abstract: Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts, certain intermediates and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: July 11, 1980
    Date of Patent: October 13, 1981
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Imidazole or imidazoline substituted ureas
    Patent number: 4293703
    Abstract: Organic chemical compounds based upon the urea molecule are disclosed which have potent gastric secretion inhibitory properties. The urea is substituted with a heterocyclic ring which may be substituted with one or more loweralkyl groups. The urea is also substituted with loweralkyl and a lower-alkylamino loweralkyl group. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
    Type: Grant
    Filed: July 7, 1980
    Date of Patent: October 6, 1981
    Assignee: Merck & Co., Inc.
    Inventor: William A. Bolhofer
  • Fluorination process
    Patent number: 4288601
    Abstract: A process for preparing .alpha.-fluoromethyl amino acids is disclosed. The process utilizes SF.sub.4 and BF.sub.3 or AlCl.sub.3 in HF to effect the fluorination.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: September 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Janos Kollonitsch, Stephen Marburg
  • Amino substituted tetrahydrobenzindoles
    Patent number: 4282240
    Abstract: Aminosubstituted tetrahydrobenzindoles having antihypertensive activity are disclosed.
    Type: Grant
    Filed: November 23, 1979
    Date of Patent: August 4, 1981
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, James H. Jones, George F. Lundell
  • Novel 2-pyridylimidazole compounds
    Patent number: 4281005
    Abstract: Novel alkylsubstituted 2-pyridylimidazoles, halosubstituted-2-pyridylbenzimidazoles, and 2-pyridylimidazopyridines are disclosed. The compounds have pharmaceutical utility as xanthine oxidase inhibitors and/or as antihypertensive.
    Type: Grant
    Filed: June 6, 1980
    Date of Patent: July 28, 1981
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Polysubstituted-2-(3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines
    Patent number: 4279913
    Abstract: Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts, certain intermediates and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: January 29, 1979
    Date of Patent: July 21, 1981
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Motor skills tester
    Patent number: 4276546
    Abstract: An apparatus and method for testing impairment of motor skills is described comprising an electrically conducting stylus to be passed by the person being tested down a series of slots in a planar solid, the slots being in a variety of geometric shapes and having an electrically conducting edge, the stylus and the slot edges being connected to timing and counting means.
    Type: Grant
    Filed: June 6, 1980
    Date of Patent: June 30, 1981
    Inventor: Alvin Krass
  • Process for preparing amino acids and esters
    Patent number: 4275220
    Abstract: A process for preparing .alpha.-amino acids or ester thereof having an .alpha.-vinyl substituent and certain intermediates are disclosed.
    Type: Grant
    Filed: August 6, 1979
    Date of Patent: June 23, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Arthur A. Patchett, William J. Greenlee
  • N-Aralkyl containing cyanopyridines
    Patent number: 4263307
    Abstract: N-Aralkylamino-OR-propoxycyanopyridines having pharmacological activity are disclosed.
    Type: Grant
    Filed: August 2, 1979
    Date of Patent: April 21, 1981
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Di- and tri- substituted thiazoles
    Patent number: 4260609
    Abstract: Di- and tri- substituted thiazoles, one substituent being a 3-amino-2-OR-propoxy group are disclosed. The thiazoles have .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Substituted aminoalkoxypyridines, compositions and use thereof
    Patent number: 4259327
    Abstract: Substituted aminoalkoxypyridines are disclosed. The compounds are useful as pharmaceutical agents.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: March 31, 1981
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin