Patents Represented by Attorney Heidi M. Berven

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  • Process for preparing functionalized ?-butyrolactones from mucohalic acid
    Patent number: 7071339
    Abstract: A process for preparing functionalized ?-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R1, R2, and R3 may have any of the meanings defined herein
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: July 4, 2006
    Assignee: Warner Lambert Company LLC
    Inventors: Daniel Belmont, Ji Zhang
  • Process for preparing highly functionalized ?-butyrolactams and ?-amino acids
    Patent number: 6924377
    Abstract: The invention relates to a process for preparing highly functionalized ?-butyrolactams and ?-amino acids by reductive amination of mucohalic acid or its derivatives, and discloses a process for preparing pregabalin, a GABA analog with desirable medicinal activity.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: August 2, 2005
    Assignee: Warner-Lambert Company
    Inventors: Peter G. Blazecka, James Guy Davidson, III, Ji Zhang
  • Antibacterial agents
    Patent number: 6864259
    Abstract: The present invention provides compounds of Formula (I): wherein R1-R6 and K have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful as antibacterial agents. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: March 8, 2005
    Assignee: Warner-Lambert Company
    Inventors: Edmund Lee Ellsworth, Kim Marie Hutchings, Dai Nguyen, Rajeshwar Singh, Howard Daniel Hollis Showalter
  • Process for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
    Patent number: 6777560
    Abstract: A method for preparing 5-(4-fluorophenyl)-1-[2-((2R,4R)4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide (I), a key intermediate in the synthesis of atorvastatin calcium, is described.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: August 17, 2004
    Assignee: Warner-Lambert Company
    Inventors: Jade D. Nelson, Michael G. Pamment
  • Antidiabetic agents
    Patent number: 6716842
    Abstract: Compounds of formula I: wherein X, E, and R′ have any of the values defined in the specification, and their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as Non-Insulin Dependent Diabetes Mellitus. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: April 6, 2004
    Assignee: Warner-Lambert Company, LLC
    Inventors: Stephen A. Fakhoury, Helen Lee, Robert Schaum, Karen Sexton
  • 3-alkyl-3-phenyl-piperidines
    Patent number: 6602886
    Abstract: The small nonpeptides of the instant invention are tachykinin antagonists. The compounds are highly selective and functional NK3 antagonists expected to be useful in the treatment of pain, depression, anxiety, panic, schizophrenia, neuralgia, addiction disorders, inflammatory diseases, gastrointestinal disorders, vascular disorders, and neuropathological disorders.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: August 5, 2003
    Assignee: Warner-Lambert Company
    Inventors: Michael Huai Gu Chen, Fu-Zon Chung, Helen Tsenwhei Lee
  • HIV protease inhibitors
    Patent number: 6528510
    Abstract: The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: March 4, 2003
    Assignee: Warner-Lambert Company
    Inventors: Frederick Earl Boyer, Jr., John Michael Domagala, Edmund Lee Ellsworth, Christopher Andrew Gajda, Susan Elizabeth Hagen, Michael James Lovdahl, Elizabeth Ann Lunney, Larry James Markoski, Josyula Venkata Nagendra Vara Prasad, Bradley Dean Tait
  • HIV protease inhibitors
    Patent number: 6512006
    Abstract: The present invention related to novel dihydropyrones possessing 3-position nitrogen atom, which inhabit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections, and diseases, including AIDS.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: January 28, 2003
    Assignee: Warner-Lambert Company
    Inventors: Frederick Earl Boyer, Jr., John Michael Domagala, Edmund Lee Ellsworth, Christopher Andrew Gajda, Elizabeth Ann Lunney, Alexander Pavlovsky, Vara Prasad Venkata Nagendra Josyula, Bradley Dean Tait
  • Benzoxazinoes/benzothiazinones as serine protease inhibitors
    Patent number: 6509335
    Abstract: This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnornal thrombosis.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: January 21, 2003
    Assignee: Warner-Lambert Company
    Inventors: Kent Alan Berryman, Dennis Michael Downing, Danette Andrea Dudley, Jeremy John Edmunds, Lakshmi Sourirajan Narasimhan, Stephen Taras Rapundalo
  • Combinations of protein farnesyltransferase and HMG CoA reductase inhibitors and their use to treat cancer
    Patent number: 6492410
    Abstract: Novel combinations of inhibitors of protein farnesyltransferase enzymes and HMG CoA reductases enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in preventing or treating cancer, restenosis, psoriasis, endometriosis, atherosclerosis, or viral infections.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: December 10, 2002
    Assignee: Warner-Lambert Company
    Inventors: Judith Leopold, Roger Schofield Newton
  • ?E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethylpiperidine, and its antidiarrhoeal use
    Patent number: 6440997
    Abstract: (−)E-2-(3,4-dichlorocinnamyl)-1-cyclo-propylmethyl-piperidine of formula I: and its pharmaceutically acceptable salts, is useful for treating diarrhea in mammals. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.
    Type: Grant
    Filed: November 10, 1999
    Date of Patent: August 27, 2002
    Assignee: Warner-Lambert Company
    Inventors: Alain Calvet, Maria Chovet, Svein Dahl, Henry Jacobelli, Vassilia Theodorou, Pierre Riviere
  • Process for the synthesis of 1,3-diols
    Patent number: 6433213
    Abstract: An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: August 13, 2002
    Assignee: Warner-Lambert Company
    Inventors: Robert Lee Bosch, Richard Joseph McCabe, Thomas Norman Nanninga, Robert Joseph Stahl
  • Stabilization of quinapril using magnesium oxide
    Patent number: 6417196
    Abstract: The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms of degradation when prepared in a pharmaceutical composition consisting essentially of magnesium oxide as the stabilizing agent. The presence of magnesium oxide also lends itself to favorable processing conditions during the manufacture of ACE inhibitor-containing compositions, especially processing by wet granulation.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: July 9, 2002
    Assignee: Warner-Lambert Company
    Inventors: Jane Ellen Daniel, Michael Ray Harris, Gerard Clifford Hokanson, Jay Weiss
  • Isoquinolones
    Patent number: 6362181
    Abstract: Benzo[de]isoquinoline-1,3-diones which are selective inhibitors of bacterial DNA gyrase and DNA topoisomerase useful in antibacterial agents are described as well as methods for their preparation and formulation. Novel intermediates useful in the preparation of the final products are also described.
    Type: Grant
    Filed: August 11, 2000
    Date of Patent: March 26, 2002
    Assignee: Warner-Lambert Company
    Inventors: Albert Kudzoi Amegadzie, Maureen Elizabeth Carey, John Michael Domagala, Liren Huang, Ronald George Micetich, Joseph Peter Sanchez, Rajeshwar Singh, Michael Andrew Stier, Arkadii Vaisburg
  • Conformationally semi-constrained quinoxaline 2,3-diones as neuroprotective agents
    Patent number: 6340758
    Abstract: Described are neuroprotective agents of Formula I wherein R is an amino acid or nitrogen heterocyclic ring which is saturated or unsaturated of from 5 to 8 members which may have additional oxygen or sulfur atoms therein. The other provisions or substituents are described in the specification.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: January 22, 2002
    Assignee: Warner-Lambert Company
    Inventors: Brian Edward Kornberg, Sham Shridhar Nikam, Michael Francis Rafferty
  • 7-substituted quinazolin-2,4-diones useful as antibacterial agents
    Patent number: 6331538
    Abstract: The invention is a series of 7-substituted quinazolin-2,4-diones useful as antibacterial agents, processes for the preparation of the compounds, and a pharmaceutical composition containing one or more of the compounds.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: December 18, 2001
    Assignee: Warner-Lambert Company
    Inventors: John Michael Domagala, Edmund Lee Ellsworth, Liren Huang, Thomas Eric Renau, Rajeshwar Singh, Michael Andrew Stier