Patents Represented by Attorney, Agent or Law Firm Heidi S. Nebel
  • Enzyme inhibitors for metabolic redirection
    Patent number: 6686338
    Abstract: A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: February 3, 2004
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Patrick L. Iversen
  • Enzyme inhibitors for metabolic redirection
    Patent number: 6673778
    Abstract: A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: January 6, 2004
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Patrick L. Iversen
  • Compositions and methods for altering the biodistribution of biological agents
    Patent number: 6537814
    Abstract: The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: March 25, 2003
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Thomas R. Porter, Patrick L. Iversen
  • Targeted site specific antisense oligodeoxynucleotide delivery method
    Patent number: 6245747
    Abstract: The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in utility for agents such as oligonucleotides which are plagued with problems in reaching targeted sites in necessary therapeutic levels. The delivery system includes gas-filled microbubbles formed in a nitrogen-free environment. Microbubbles formed through sonication in a nitrogen-free environment are smaller and more stable than microbubbles sonicated in the presence of room air.
    Type: Grant
    Filed: July 13, 1998
    Date of Patent: June 12, 2001
    Assignee: The Board of Regents of the University of Nebraska
    Inventors: Thomas R. Porter, Patrick L. Iversen, Gary D. Meyer