Abstract: Novel synthetic isohirudins with improved stability The invention relates to novel synthetic isohirudins which have improved stability owing to exchange in the region of the Asp-Gly motif. This results, on the one hand, in an increase in the yield during workup and, on the other hand, in making possible pharmaceutical formulation as directly injectable solution ready for use.

Abstract: A charge trasfer imaging device is disclosed, which comprises photosensitive sites formed in and continuous to the surface of a semiconductor substrate for generating and storing signal charge in response to an incident light signal, a shift electrode for controlling the transfer of the signal charge through the semiconductor substrate, and a charge transfer shift register for reading out the signal charge by transferring the same from the shift electrode through transfer channels formed in and continuous to the semiconductor substrate surface. Semiconductor region of the opposite conductivity type to the semiconductor substrate is formed in the substrate other than a portion of the substrate below the photosensitive sites and at least under the transfer channels of the shift register, and a reverse bias voltage is applied between these semiconductor regions and the semiconductor substrate.

Abstract: The container valve housing is provided with two concentric bearing walls having different heights, the outer bearing wall being fitted with a gasket which is traversed by the valve stem and the inner bearing wall being applied against the gasket so as to form an internal chamber which communicates with the product to be dispensed. An annular wall between the two bearing walls is provided with filler openings and with at least one independent calibrated bleeder orifice or tap for the admission of propellant gas from the headspace of the container into the internal chamber.