Abstract: Disclosed are compounds of the formula:
wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein.
Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Type:
Grant
Filed:
December 20, 2001
Date of Patent:
October 5, 2004
Assignee:
Schering Corporation
Inventors:
Timothy Guzi, Dinanath F. Rane, Alan K. Mallams, Alan B. Cooper, Ronald J. Doll, Viyyoor M. Girijavallabhan, Arthur G. Taveras, Corey Strickland, Joseph M. Kelly, Jianping Chao
Abstract: Methods are provided for treating cancer, comprising administering (1) a farnesyl protein transferase inhibitor in conjunction with (2) an additional Ras signaling pathway inhibitor to induce cancer cell death and tumor regression.
Abstract: Disclosed are compounds of the formula:
wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein.
Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted.
Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Type:
Grant
Filed:
December 20, 2001
Date of Patent:
May 25, 2004
Assignee:
Schering Corporation
Inventors:
Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Alan K. Mallams, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Adriano Afonso, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang, Jay Weinstein
Abstract: A process for producing compounds of the formula:
is disclosed. The compound of formula 1.0 is produced by:
(1) separating the atropisomers of
to obtain the atropisomers
(2) heating the atropisomer of formula 2.0B at a suitable temperature in a suitable solvent to obtain a mixture of atropisomers of formulas 2.0A and 2.0B; (3) separating the atropisomers of formulas 2.0A and 2.0B of step (2); and (4) reducing the atropisomer of formula 2.0A to obtain a compound of formula 1.0. Preferably, R1 is Br, R2 is Cl and R3 is Br.
Also disclosed is the (+)-atropisomer of formula 2.0 wherein R1 is Br, R2 is Cl and R3 is Br.
Type:
Grant
Filed:
July 1, 1999
Date of Patent:
March 16, 2004
Assignee:
Schering Corporation
Inventors:
F. George Njoroge, Bancha Vibulbhan, Viyyoor M. Girijavallabhan
Abstract: Methods are provided for treating multidrug resistance in refractory tumor cells comprising administering (1) a P-glycoprotein inhibitor in conjunction with (2) an antineoplastic agent.
Type:
Grant
Filed:
March 22, 2002
Date of Patent:
March 9, 2004
Assignee:
Schering Corporation
Inventors:
William W. Johnson, Er-Jia Wang, Christopher Casciano, Robert P. Clement
Abstract: Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Abstract: Novel compounds of the formula:
or a pharmaceutically acceptable salt or solvate thereof, wherein:
a represents N or NO−;
R1 and R3 are the same or different and each represents halo;
R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H;
T is a substituent selected from SO2R or
Z is O or S;
n is zero or an integer from 1 to 6;
R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2;
R5 is H, alkyl, aryl, heteroaryl or cycloalkyl.
Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Type:
Grant
Filed:
September 4, 2002
Date of Patent:
February 10, 2004
Assignee:
Schering Corporation
Inventors:
Alan B. Cooper, Ronald J. Doll, Anil K. Saksena, Viyyoor M. Girijavallabhan
Abstract: This invention discloses novel gamma secretase inhibitors of the formula:
wherein: R1 is a substituted aryl or substituted heteroaryl group; R2 is an R1 group, alkyl, —X(CO)Y, —(CR32)1-4X(CO)Y; each R3A is independently H or alkyl; X is —O—, —NH, or —N-alkyl; and Y is —NR6R7, or —N(R3)(CH2)2-6NR6R7. Also disclosed is a method of treating Alzheimer's Disease.
Type:
Grant
Filed:
August 1, 2002
Date of Patent:
January 27, 2004
Assignee:
Schering Corporation
Inventors:
Theodoros Asberom, Henry S. Guzik, Hubert B. Josien, Dmitri A Pissarnitski
Abstract: Novel compounds, such as:
are disclosed.
Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.
Type:
Grant
Filed:
March 8, 2000
Date of Patent:
June 10, 2003
Assignee:
Schering Corporation
Inventors:
Ronald J. Doll, Joseph M. Kelly, Alan K. Mallams, F. George Njoroge, Stacy W. Remiszewski, Arthur G. Taveras
Abstract: The present invention describes compounds useful for the inhibition of Farnesyl Protein Transferase. This invention also discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with FPT.
Type:
Grant
Filed:
November 27, 2001
Date of Patent:
March 4, 2003
Assignee:
Schering Corporation
Inventors:
F. George Njoroge, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Xiongwei Shi
Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0
Also disclosed are novel compounds of the formulas:
and
Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3.
Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
Type:
Grant
Filed:
May 16, 2000
Date of Patent:
December 10, 2002
Assignee:
Schering Corp.
Inventors:
W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
Abstract: Novel compounds of the formula:
wherein a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents
wherein R5 is H (C1-C6)alkyl or a bond; b and c are independently 0 to 3 and Y is a three, four, five or six membered cycloalkyl ring, pyridyl, pyrazinyl or phenyl are disclosed. Pharmaceutical Compositions containing such compounds, methods of inhibiting farnesyl protein transferase and methods for treating tumor cells using such compounds or compositions are also disclosed.
Abstract: Disclosed are compounds of the formula:
wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group; R8 represents H when the alkyl chain between the amide group and the R13 imidazole group is substituted, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R8 is H, and the alkyl chain between the amide group and the R13 imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Type:
Grant
Filed:
December 16, 1999
Date of Patent:
April 16, 2002
Assignee:
Schering Corporation
Inventors:
Arthur G. Taveras, Ronald J. Doll, Alan B. Cooper, Johan A. Ferreira, Timothy Guzi, Dinanath F. Rane, Viyyoor M. Girijavallabhan, Cynthia J. Aki, Jianping Chao, Carmen Alvarez, Joseph M. Kelly, Tarik Lalwani, Jagdish A. Desai, James J-S Wang
Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0:
to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
Novel compounds of the formulas 5.0, 5.1 and 5.2, wherein R is —C(R20)(R21)(R46), and 5.3, 5.3A and 5.3B, wherein R is —N(R25)(R48), are disclosed.
Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.
Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.
Type:
Grant
Filed:
July 9, 1999
Date of Patent:
April 2, 2002
Assignee:
Schering Corporation
Inventors:
Robert W. Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
Abstract: Disclosed are compounds of the formula:
wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
Type:
Grant
Filed:
December 16, 1999
Date of Patent:
March 26, 2002
Assignee:
Schering Corporation
Inventors:
Timothy Guzi, Dinanath F. Rane, Alan K. Mallams, Alan B. Cooper, Ronald J. Doll, Viyyoor M. Girijavallabhan, Arthur G. Taveras, Corey Strickland, Joseph M. Kelly, Jianping Chao
Abstract: Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0
Also disclosed are novel compounds of the formulas:
Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3.
Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
Type:
Grant
Filed:
July 7, 1999
Date of Patent:
October 9, 2001
Assignee:
Schering Corporation
Inventors:
W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
Abstract: The invention relates to compounds of the formula
wherein R1, R2, R3, R4, R5, R6, R7, R8, Y, A, B, X, a, b, c, d, v, and w are as described herein. The compounds of formula (1.0) are useful for inhibiting tumor growth.
Type:
Grant
Filed:
July 13, 1999
Date of Patent:
August 21, 2001
Assignee:
Schering Corporation
Inventors:
F. George Njoroge, Ronald J. Doll, Stacy W. Remiszewski
Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0:
to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5.1 and 5.2 are disclosed.
Type:
Grant
Filed:
September 21, 1999
Date of Patent:
June 5, 2001
Assignee:
Schering Corporation
Inventors:
W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
Abstract: Novel compounds of the formula:
or a pharmaceutically acceptable salt or solvate thereof, wherein:
a represents N or NO−;
R1 and R3 are the same or different and each represents halo;
R2 and R4 are the same or different and each is selected from H and halo, provided that at least one of R2 and R4 is H;
T is a substituent selected from SO2R or:
Z is O or S;
n is zero or an integer from 1 to 6;
R is alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, heterocycloalkyl, or N(R5)2;
R5 is H, alkyl, aryl, heteroaryl or cycloalkyl.
Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
Type:
Grant
Filed:
June 15, 1998
Date of Patent:
May 29, 2001
Assignee:
Schering Corporation
Inventors:
Alan B. Cooper, Ronald J. Doll, Anil K. Saksena, Viyyoor M. Girijavallabhan