Patents Represented by Attorney, Agent or Law Firm Heska Corporation
  • Method to detect canine IgE and kit therefor
    Patent number: 6060326
    Abstract: The present invention includes a method to detect canine IgE using a canine Fc epsilon receptor (Fc.sub..epsilon. R) to detect canine IgE antibodies in a biological sample from a canid. The present invention also relates to kits to perform such methods.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: May 9, 2000
    Assignee: Heska Corporation
    Inventors: Glenn R. Frank, Keith E. Rushlow
  • Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof
    Patent number: 6057127
    Abstract: The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to mediate Fc epsilon receptor-mediated biological responses.
    Type: Grant
    Filed: January 29, 1998
    Date of Patent: May 2, 2000
    Assignee: Heska Corporation
    Inventors: Eric R. Weber, Catherine A. McCall
  • Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof
    Patent number: 6042825
    Abstract: The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins; antibodies raised against such asparaginase proteins; and compounds that inhibit parasitic helminth asparaginase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: March 28, 2000
    Assignees: Heska Corporation, Colorado State Universty Research Foundation
    Inventors: Ramaswamy Chandrashekar, Naotoshi Tsuji
  • Flea epoxide hydrolase nucleic acid molecules, proteins and uses thereof
    Patent number: 6037160
    Abstract: The present invention relates to arthropod epoxide hydrolase proteins; to arthropod epoxide hydrolase nucleic acid molecules, including those that encode such epoxide hydrolase proteins; to antibodies raised against such epoxide hydrolase proteins; and to other compounds that inhibit arthropod epoxide hydrolase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from hematophagous arthropod infestation.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: March 14, 2000
    Assignee: Heska Corporation
    Inventors: Nancy Wisnewski, Gary M. Silver, Katherine Cailles Lo, Kevin S. Brandt
  • Inhibition of the binding human IgE to its receptor by tetracyclic compounds for the alleviation of IgE-mediated immune response
    Patent number: 5965605
    Abstract: Disclosed are chemical agents with unexpected activity to inhibit the interactions between human immunoglobulin E (IgE) and its receptor (Fc.epsilon.RI) which interactions are known to be involved in triggering allergic responses. The agents may be used to module the allergic response in the treatment of various clinical conditions, including rhinitis, asthma, urticaria, atopic dermatitis, and anaphylacric shock. The agents can be formulated for oral, topical or parenteral administration.
    Type: Grant
    Filed: December 29, 1997
    Date of Patent: October 12, 1999
    Assignee: Heska Corporation
    Inventors: Y.-S. Edmond Cheng, Yuan Liu, John Chu, Jean-Pierre Kinet, Marie-Helene Jouvin, Yukio Sudo, Xiuqi Qian
  • Feline Fc epsilon receptor alpha chain proteins and therapeutic uses thereof
    Patent number: 5958880
    Abstract: The present invention relates to feline Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to mediate Fc epsilon receptor-mediated biological responses.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: September 28, 1999
    Assignee: Heska Corporation
    Inventors: Glenn R. Frank, James P. Porter, Keith E. Rushlow, Donald L. Wassom, Eric R. Weber
  • Composition to protect a mammal against Bartonella henselae infection
    Patent number: 5958414
    Abstract: The present invention relates to a therapeutic composition to protect a mammal from B. henselae infection that includes an isolated B. henselae antigen and an adjuvant comprising a phosphazene polymer. Also included is a method to use such a therapeutic composition to protect a mammal from B. henselae infection. One embodiment is a method to protect a human from cat scratch disease by administering such a therapeutic composition to a domestic cat in contact with the human. The present invention also includes a method to produce such a therapeutic composition.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: September 28, 1999
    Assignees: Heska Corporation, Avant Immunotherapeutics, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Russell L. Regnery, Jane A. Rooney, Sharon A. Jenkins
  • Method to detect IgE
    Patent number: 5945294
    Abstract: The present invention includes a method to detect IgE using a human Fc epsilon receptor (Fc.sub..epsilon. R) to detect IgE antibodies in a biological sample from a cat, a dog, or a horse. The present invention also relates to kits to perform such methods.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: August 31, 1999
    Assignee: Heska Corporation
    Inventors: Glenn R. Frank, James P. Porter, Keith E. Rushlow, Donald L. Wassom
  • Dirofilaria and brugia ankyrin proteins, nucleic acid molecules, and uses thereof
    Patent number: 5942226
    Abstract: The present invention relates to Dirofilaria ankyrin proteins and to Brugia ankyrin proteins; to Dirofilaria ankyrin nucleic acid molecules and to Brugia ankyrin nucleic acid molecules, including those that encode such ankyrin proteins; to antibodies raised against such ankyrin proteins; and to compounds that inhibit Dirofilaria or Brugia ankyrin function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: August 24, 1999
    Assignee: Heska Corporation
    Inventors: Liang Tang, E. Scot Blehm
  • Parasitic helminth asparaginase proteins, nucleic acid molecules, and uses thereof
    Patent number: 5854051
    Abstract: The present invention relates to: parasitic helminth asparaginase proteins; parasitic helminth asparaginase nucleic acid molecules, including those that encode such asparaginase proteins; antibodies raised against such asparaginase proteins; and compounds that inhibit parasitic helminth asparaginase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: December 29, 1998
    Assignees: Heska Corporation, Colorado State University Research Foundation
    Inventors: Ramaswamy Chandrashekar, Naotoshi Tsuji
  • Dirofilaria and Brugia ankyrin proteins, nucleic acid molecules, and uses thereof
    Patent number: 5827692
    Abstract: The present invention relates to Dirofilaria ankyrin proteins and to Brugia ankyrin proteins; to Dirofilaria ankyrin nucleic acid molecules and to Brugia ankyrin nucleic acid molecules, including those that encode such ankyrin proteins; to antibodies raised against such ankyrin proteins; and to compounds that inhibit Dirofilaria or Brugia ankyrin function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: October 27, 1998
    Assignee: Heska Corporation
    Inventors: Liang Tang, E. Scot Blehm
  • Dirofilaria and brugia ankyrin proteins, nucleic acid molecules, and uses thereof
    Patent number: 5824306
    Abstract: The present invention relates to Dirofilaria ankyrin proteins and to Brugia ankyrin proteins; to Dirofilaria ankyrin nucleic acid molecules and to Brugia ankyrin nucleic acid molecules, including those that encode such ankyrin proteins; to antibodies raised against such ankyrin proteins; and to compounds that inhibit Dirofilaria or Brugia ankyrin function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: October 20, 1998
    Assignee: Heska Corporation
    Inventors: Liang Tang, E. Scot Blehm
  • Filariid nematode cysteine protease proteins, nucleic acid molecules and uses thereof
    Patent number: 5795768
    Abstract: The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 18, 1998
    Assignees: Heska Corporation, Colorado State University Research Foundation
    Inventors: Cynthia Ann Tripp, Nancy Wisnewski, Robert B. Grieve, Glenn R. Frank
  • Dirofilaria and onchocerca larval L3 cysteine protease proteins and uses thereof
    Patent number: 5792624
    Abstract: The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 11, 1998
    Assignees: Heska Corporation, Colorado State University Research Foundation
    Inventors: Cynthia Ann Tripp, Nancy Wisnewski, Robert B. Grieve, Glenn R. Frank, Jennifer K. Richer