Abstract: Combinatorial chemical libraries of the Formula [S]—C(O)—L′—Z containing dihyroxy amides and hydroxyphosphonate amides are disclosed, in which [S] represents a solid support and —L′—Z is a linker/ligand residue. In these libraries, Z is and Y is —P(O)(OR6)(OR7), —CH(OH)—COR8, —CH,CH═CH2—CH2CH(OH)CH2OH, —CH2CHO, —CH2CH2OH, —CH2CH2OC(O)NHR26, —CH2CH2NR27R28, or The combinatorial libraries are optionally encoded with tags. The use of these libraries in assays to discover biologically active compounds is also disclosed.

Abstract: Peptides containing the amino acid sequence, aa1-aa2-aa3-aa4-(Gly)n, devices for implantation coated with the peptides and methods for altering cell adhesion using the peptides are disclosed. The residues aa1, aa2, and aa4 are independently Lys, Arg, Orn or, when the residue is N-terminal, Acp. The residue aa3 is Ala, Gly, Val, Leu, Ile, Ser, Thr, Cys, Met, Asn, Nle, Nva or Abu. The preferred sequence is KRSR. Peptides containing cell adhesion-related sequences can be incorporated into or coated onto substrates to enhance osteoblast adhesion.

Abstract: A portable computing device includes a processing unit coupled with a keyboard, a recording medium, and a display. The keyboard and the recording medium form portions of a support structure of the device and are generally directed in different directions. The recording medium is configured to receive input from a stylus operated by a user. The display is movable (e.g., pivotable and/or translatable) about the support structure to selectively suit use of the display in conjunction with the keyboard or use of the display in conjunction with the stylus and the recording medium. An elongatable arm can serve to connect the display with the support structure.

Abstract: The invention pertains to the field of Augmentative Communication Technology. The invention addresses the problem of providing a communication device for producing message output reflecting a user's intended message which minimizes the amount of user input required to produce a message. The invention pertains to an augmentative communication system in which user input may specify attributes of a predefined subject of desired communication. Responsive to such input, a system in accordance with the invention may provide to the user a set of predefined messages which are pertinent to the specified subject. From this set of messages the user may specify a message to be produced as output for purposes of communication. Alternatively, the user may alter the specified attributes and receive a different set of predefined messages based on the revised specifications.

Abstract: Methods for fabricating laminations to form structural elements of predetermined shapes (120, 220, 420, 520, 620) are provided. Laminations include parts (22, 24) fabricated from the tread portion (42) of discarded rubber tires. The parts are typically arranged in layers with various relationships therebetween. The parts are pressed to remove all voids therebetween causing dynamic tension which creates rigidity and then bonded with methods including vulcanization, chemical vulcanization, epoxy and adhesive.

Abstract: Improvements in placement of timing patterns in self-servowriting include detecting and correcting for media defects. A detector is used to detect whether a trigger pattern is within an expected location on the storage medium. If the trigger pattern is not detected, then a physical defect may be present. Thus, in one example, a false trigger pattern is generated. Additionally, a determination is made as to whether a trigger pattern is within an expected trigger pattern region. When the trigger pattern is not within the expected range, then a valid interval window may be modified to adjust the expected trigger pattern region.

Abstract: Apparatus for cooling an electronic device, and a resultant fluid-cooled electronic apparatus are provided. In one embodiment, the apparatus includes a heat sink member with a surface for making thermal contact with the electronic device. The heat sink member has a plurality of channels for carrying coolant fluid. The plurality of channels are positioned in a first group and a second group such that coolant flow alternates across the member. At least one channel of the plurality of channels has a fluid flow cross-section that varies over a length thereof to selectively enhance a heat transfer coefficient of the coolant fluid within the channel and thereby produce a more uniform temperature at the surface of the heat sink member when making thermal contact with the electronic device.

Abstract: A checkpoint of a process is taken in order to provide a consistent state of the process in the event the process is to be restarted. When the process is restarted, the process is placed in the state it was in when the checkpoint was taken. However, there are times when certain information has changed since the last checkpoint and it should not be restored. For example, if a process is restarted on a computing unit different from the one in which the checkpoint is taken, then various attributes associated with external data referenced by the process (e.g., an address to an external function/variable) might be different than at the time of the checkpoint. Similarly, even on the same computing unit, if the functions and/or variables are reloaded, the attributes may be different. Since these new attribute values are needed for the restarted process, they should not be restored. In order to prevent restoration of the attributes, only part of the Data Section is restored.

Abstract: A method and composition are disclosed utilizing the pure (S) isomer of salmeterol which is a potent bronchodilator with reduced adverse effects, having a better selectivity for &bgr;2 receptors than the corresponding R enantiomer or the racemate.

Abstract: A combinatorial chemical library comprising a plurality of members of the Formula [S]—C(O)—L′-Z containing hydroxyamides is disclosed, in which [S] represents a solid support and L′-Z is a linker/compound residue. In this library, Z is and Y is —NR3R4 or —OR9. R3 and R4 are independently selected from the group consisting of H, alkyl, aralkyl, heteroarylalkyl, heterocycloalkyl, —CH(R5)CH(R6)OH, —CH(R5)C(O)NHR6 and —CH(R5)C(O)NHCH(R6)C(O)NHR7. R3 and R4 together are wherein X=O or NR8 and R9 is aryl, aralkyl or R7CH═CH(CH2){overscore (n)}. The combinatorial library can be optionally encoded with identifiers T′-L, which are covalently attached to the solid support. The methods of synthesizing such a library are described. The use of such library in assays to discover biologically active compounds is also disclosed.

Abstract: A method for remotely administering one or more nodes of a distributed data processing system to provide mirroring of operating system images, and/or designating of alternate volume groups for the one or more nodes. A new data class is defined in a system data repository (SDR) coupled to a control node of the distributed system. A set of commands are provided to initiate and discontinue mirroring from the control node on a nodal volume group, along with designating alternate volume groups for remote installation on one or more nodes of the system in parallel. An interface to add, delete, modify or display information about nodal volume groups is also provided.

Abstract: A substrate that is substantially non-wettable to adhesive resin is disclosed. The substrate is coated with a fluorinated silane composition. Preferable fluorosilane compositions include perfluoroalkyl alkylsilanes of Formula III: R5nR6mSiX4-(n+m)  III wherein R5 is a perfluoroalkyl alkyl radical; R6 is alkyl or alkenyl; X is acetoxy, halogen or alkoxy; n is 1 or 2; and m is 0 or 1. The composition is preferably applied in solution and upon evaporation of the solvent, forms a durable, non-wetting, yet well-adhering surface. In a preferred embodiment, the substrate is a chip carrier with enhanced wire bondability for use in the manufacture of a semiconductor device.

Abstract: Method, system and computer program product are provided for real time evaluation of compressed picture quality, in hardware, software or a combination thereof, during encoding of a sequence of video data. A received video signal is encoded by quantizing the signal after frequency transformation to produce a quantized video signal which is automatically evaluated in real time for data loss. Loss statistics, representative of picture quality of the quantized video signal, are generated for comparison with, for example, a predefined threshold as a dynamic control over outputting of the quantized video signal to the encode pipeline. As an enhancement, multiple quantizers are employed in parallel, each using a different quantization scale to produce multiple different quantization signals. The multiple quantization signals are evaluated in real time for picture quality and an optimum signal is selected for forwarding within the encode pipeline.

Abstract: Improvements in placement of timing patterns in self-servowriting include correcting for systematic errors due to geometric effects. A correction is made for varying systematic errors, such as when the recording head has spatially separate read and write elements. Further, servopattern rotation due to residual or unmeasured systematic errors is reduced by using a once per revolution clock index derived from the motor drive current waveform or any other sensor. In one aspect of correcting for systematic errors in the writing of timing patterns on a storage medium of a storage device, a time interval between a trigger pattern written at a first radial position of the storage medium and a rotational index is measured. The rotational index is related to the rotational orientation of the storage medium with respect to a fixed frame of the storage device.

Abstract: Object-code instruction traces are employed to analyze selected instructions of an application program for possible failure when confronted by a year-2000 date. The analysis includes directly identifying one or more instructions of the application program that may fail, as well as identifying whether the one or more instructions have a characteristic of a predefined false-positive failure pattern. A failure-pattern descriptor is assigned to each examined instruction which is indicative of whether the instruction may fail when confronted by a date in the year-2000 range, and whether the instruction is a possible false-positive failing instruction. The analysis employs user-specifiable run-control values, as well as predetermined filter-specification values in comparing traces of each selected object-code instruction to predefined instruction failure patterns.