Abstract: A monoclonal antibody, or fragments thereof, having binding specificity for both endoglin expressed on human vascular endothelial cells and on murine endothelial cells. Antiangiogenic therapy in mammals can be effected by administering to the mammalian host a therapeutically effective amount of an anti-endoglin monoclonal antibody, or fragment thereof, either unconjugated or conjugated to at least one angiogenesis inhibitor or antitumor agent. The composition is useful for treating tumor and angiogenesis-associated diseases.
Abstract: The present invention relates to an apparatus that forms a polymeric structure. The apparatus has a mold plate, a circular trench, a male and female interconnect, a vertical gap filler, and a cylinder. The mold plate has a predetermined geometric design. The circular trench is in the mold plate and the difference between the outer diameter and the inner diameter of the circular trench is a distance D. The male interconnect and the female interconnect are interspaced between each other. Each interconnect rotates within the circular trench and has a base and an interconnection portion. Each base has a width D and slidably mates to the mold plate. Each interconnect portion has a minimum width W which is less than D. The male interconnect portion protrudes downwards relatively from its base to a distance P, likewise the female interconnect portion protrudes upwards relatively from its base to a distance P. The vertical gap filler aligns with the circular trench and has a foundation and an extension.
Abstract: An expandable framework for attachment of display panels and the like. The linkage is lockable in one or more configurations intermediate the collapsed and fully expanded configurations so that the same framework may be used for more than one type of display, such as floor display and table-top display. A shipping case for containing the framework, when collapsed, is convertible into a podium by wrapping a decorative panel about the case and fastening the panel thereto to be flush with an upper platform on the case.
Abstract: The present invention discloses a method for increasing the efficiency of transfection of cells by incubating the transfected cells with an inhibitor of apoptosis. In one embodiment, the inhibitor of apoptosis is a caspase inhibitor.
Type:
Grant
Filed:
November 24, 1999
Date of Patent:
February 13, 2001
Assignee:
Health Research, Inc.
Inventors:
Sek W. Hui, Shawn P. Murphy, Lin H. Li, Arindam Sen
Abstract: A lighter assembly especially suitable for burning butane gas as a fuel is provided in modular form which consists essentially of two unitary subassemblies which may be detachably mounted together to form the assembled lighter. The lighter assembly, which features low cost and structural simplicity, is constructed with the first subassembly comprising a hollow body defining a chamber for storing the fuel, an inlet valve assembly for inserting fuel into said chamber, a burner valve assembly for controlling emission of the fuel from said chamber, and a burner valve actuating arm for opening and closing the burner valve.
Abstract: The present invention is directed to a compound for preventing snoring. Essentially, the compound includes various natural oils such as almond oil, olive oil, sunflower oil, and peppermint oil, which serve to lubricate the soft tissue including the uvula and soft palette during sleep. In that manner, the oils dampen the friction of the soft tissue and diminish the noise associated with snoring. The present anti-snoring compound also includes a magnesium-based compound, which helps the oils cling to the soft tissue. If desired, vitamins B6, C and E are also included in the formulation of the present anti-snoring composition, primarily for the health benefit derived from them.
Type:
Grant
Filed:
October 28, 1999
Date of Patent:
February 13, 2001
Assignees:
Innovative Chemical Corporation, MedGen Inc.
Inventors:
Paul S. Mitchell, Gary Robinson, Paul B. Kravitz
Abstract: A latching device eg for attaching a breathing mask to an aircrew helmet, has detents (20) on a receptacle portion (10), and teeth (32) on carriers (30,31) supported for arcuate movement in an insert portion (14) and supported (eg at 33) so that bending loads on the carriers are substantially avoided.
Abstract: A heat exchanger tube having an internal surface that is configured to enhance the heat transfer performance of the tube. The internal enhancement has a plurality of polyhedrons extending from the inner wall of the tubing. The polyhedrons have first and second planar faces disposed substantially parallel to the polyhedral axis. The polyhedrons have third and fourth faces disposed at an angle oblique to the longitudinal axis of the tube. The resulting surface increases the internal surface area of the tube and the turbulence characteristics of the surface, and thus, increases the heat transfer performance of the tube.
Abstract: An alkali metal, solid cathode, nonaqueous electrochemical cell capable of delivering high current pulses, rapidly recovering its open circuit voltage and having high current capacity, is described. The stated benefits are realized by the addition of at least one organic sulfate additive to an electrolyte comprising an alkali metal salt dissolved in a mixture of a low viscosity solvent and a high permittivity solvent. A preferred solvent mixture includes propylene carbonate, dimethoxyethane and a sulfate additive having at least one unsaturated hydrocarbon containing a C(sp2 or sp3 )—C(sp3) bond unit having the C(sp3) carbon directly connected to the —OSO3— functional group, or a silyl sulfate or a tin sulfate.
Abstract: A heat transfer tube having an inner surface provided with a dense pattern of polyhedrons having crack-like cavities on at least two surfaces of a single polyhedron, forming three-dimensional crack-like cavities that enhance flow evaporation heat transfer. The tube is made by (a) forming in an inner surface for the tube a plurality of generally parallel first grooves, (b) forming in the inner surface and over the first grooves a plurality of generally parallel second fins extending at a first angle of between 0 and about 25 degrees relative to a longitudinal axis for the tube to thereby devolve the second angle fins into the pattern of cavities, and (c) forming in the second fins a pattern of generally parallel crosshatches extending cross-wise thereto.
Abstract: A lithium ion electrochemical cell having high charge/discharge capacity, long cycle life and exhibiting a reduced first cycle irreversible capacity, is described. The stated benefits are realized by the addition of at least one dicarbonate additive to an electrolyte comprising an alkali metal salt dissolved in a solvent mixture that includes ethylene carbonate, dimethyl carbonate, ethylmethyl carbonate and diethyl carbonate. The preferred additive is an alkyl dicarbonate compound.
Abstract: This invention relates to a microporous or macroporous affinity filtration membrane wherein the matrix of the membrane is composed of chitin and the pores are made by dissolution of porogen during the preparation of the membrane. The invention also relates to a method for the purification of wheat germ agglutinin using chitin microprous or macroporous membranes.
Type:
Grant
Filed:
November 29, 1999
Date of Patent:
January 16, 2001
Assignee:
The Research Foundation of State University of New
York
Abstract: The present invention is directed to the realization that the dimensions and basis weight of an electrode active admixture such as a transition metal oxide, and particularly silver vanadium oxide, formed into an electrode structure from an admixture paste subjected to a calendering process are influenced by the calender direction. To obtain electrode structures of a desired low basis weight requires a secondary calendering step performed in a direction reverse or orthogonal to that used to form the initial sheet tape. Orthogonal or reverse feed of the electrode active admixture provides for fibrillation of the fluoro-polymeric binder in other than the initial direction. This lets the binder spread in directions transverse to the initial direction to form the low basis weight electrode active structure.
Type:
Grant
Filed:
April 21, 1999
Date of Patent:
January 16, 2001
Assignee:
Wilson Greatbatch Ltd.
Inventors:
William C. Thiebolt, III, Douglas P. Eberhard, Jeffrey C. Grisante
Abstract: A method for enhancing the effect of anti-tumor agents on solid tumors is provided. The method comprises administering to an individual an anti-tumor agent and a hematocrit elevator. The hematocrit elevator may be administered before or concurrently with the anti-tumor agent.
Abstract: An alkali metal/solid cathode electrochemical cell, particularly a Li/SVO cell, having an anode-to-cathode (A/C) capacity ratio of about 0.68 to about 0.96, is described. This provides the cell with negligible, if any, cell swelling during discharge.
Abstract: A tongue cleaner having an elongate shank portion for holding thereof and a portion extending from one end thereof for supporting a tongue scraping edge. The support portion is skewed relative to the shank portion to slope downwardly for effecting engagement of the edge with a posterior part of the upper surface of the tongue so that the posterior part may be comfortably scraped.
Type:
Grant
Filed:
June 19, 1996
Date of Patent:
January 9, 2001
Inventors:
Dasan Potti, Jon L. Richter, Gordon Neufeld
Abstract: A "fuel gauge" for a pulse dischargeable alkali metal/solid cathode cell is described. The rate of voltage recovery is used to determine the state of charge of the cell. Voltage recovery includes recovery from one load to a second, lighter load, or a loaded condition to OCV. The present invention is particularly useful as an end-of-life indicator for a Li/CF.sub.x cell powering an implantable medical device.
Type:
Grant
Filed:
March 9, 2000
Date of Patent:
December 26, 2000
Assignee:
Wilson Greatbatch Ltd.
Inventors:
Esther S. Takeuchi, Noelle M. Waite, Kenneth C. Syracuse
Abstract: An electrochemical cell comprising a medium rate electrode region intended to be discharged under a substantially constant drain and a high rate electrode region disposed in a jellyroll wound configuration intended to be pulse discharged, is described. Both electrode regions share a common anode and are activated with the same electrolyte.
Abstract: A radiation shield (2) for a flexible tube such as a source guide tube (4) of a radiography projector system, said shield comprising a flexible sleeve (6) comprising an axial assembly of axially overlapping tubular units (10) of elastomeric material containing particles of radiation attenuating material. In a preferred embodiment, the tubular units each comprise a female section and a male section disposed at opposite ends of the unit, said male section being adapted to be a push fit into the female section of a like unit. The sleeve is preferably protected by a sheath (8) e.g. of a braided metal wire. Also described is a flexible source guide tube assembly for use with a radiography source projector system, said assembly comprising a flexible source guide tube within a radiation shield in the form of a flexible sleeve for the tube, said sleeve comprising elastomeric material containing particles of radiation attenuation material.