Abstract: A sensor has a sensor substance, an electromagnetic energy source, and a detector. The sensor substance may be able to emit electromagnetic energy different than that provided by the energy source when an analyte of interest is in contact with the sensor substance and electromagnetic energy is received by the sensor substance. The energy source and the detector may be provided on the same side of the sensor substance. In a method according to the invention, a determination may be made as to whether an analyte is present in a sample. Such a method may provide a sensor, such as that described above. Electromagnetic energy may be provided to the sensor substance using the energy source, and the sensor substance may be contacted with a sample. Electromagnetic energy may be emitted from the sensor substance and received at the detector. The detector may provide a signal indicating the type of electromagnetic energy emitted from the sensor substance.
Type:
Grant
Filed:
October 1, 2004
Date of Patent:
March 1, 2011
Assignee:
The Research Foundation of State University of New York
Inventors:
Albert H. Titus, Frank V. Bright, Alexander N. Cartwright
Abstract: A firebox apparatus is adapted for transport on a vehicle having a roll-off hoist mechanism by providing parallel guides on the underside of a supporting skid assembly of the firebox apparatus for engaging siderails of a tiltable roll-off track of the hoist mechanism, and by providing reinforced front and rear portions connecting parallel longitudinal skid members to maintain an opening at the bottom of the firebox apparatus yet make the firebox apparatus sufficiently sturdy to withstand loads encountered during loading an unloading from the transport vehicle. The firebox apparatus includes an air curtain system for limiting pollution resulting from incineration of waste. The present invention enables easy installation and removal of the firebox apparatus in crowded environments, such as urban environments, to cleanly burn waste.
Abstract: A system for quickly removing and installing check valve parts without disturbing system piping attached to a pump. The system includes a first adapter attached to the outlet of the pump head. The first adapter includes a valve seat and a housing with a side wall having external threads. A second adapter includes a hollow body with a space for a check valve. The body has an opening in the side wall for inserting the check valve. The second adapter fits over the first adapter and the adapters are attached by means of a collar. Tightening the collar onto the threads on the first adapter causes the check valve to be held firmly between the valve seat and the top wall of the second adapter.
Abstract: A stereomicroscope (20) has first and second main beam paths (21, 22) whose spacing defines a stereo base (23), a microscope axis (24) proceeding through the center of the stereo base (23) parallel to the main beam paths; and an optical beam splitter device (30) for generating an assistant's beam path (31) and a documentation beam path (32), the assistant's beam path being outcoupled from the first main beam path in a first position of the beam splitter device, and from the second main beam path in a second position, and the documentation beam path being outcoupled from the other main beam path; and the direction of the assistant's beam path in the first position being rotated 180° relative to the assistant's beam path in the second position; and the outcoupled documentation beam path extending, in both positions of the beam splitter device, perpendicular to the outcoupled assistant's beam path.
Abstract: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.
Type:
Grant
Filed:
October 17, 2008
Date of Patent:
February 22, 2011
Assignee:
University of Rochester
Inventors:
Michael King, Nichola Charles, Jane Liesveld, John P. Gentile, Nathan A. Clark, Nipa A. Mody
Abstract: A prefabricated panel assembly for use in constructing a marine vessel comprises a plurality of elongated, roll-formed metal panels fixed sided to side by longitudinal weld seams. The panels include a plate portion and an angle portion adjoining the plate portion along a longitudinal primary bend, the plate portion having a generally flat panel segment, the angle portion having a web generally orthogonal to the panel segment and a flange generally parallel to the panel segment and adjoining the web along a secondary bend. The panel assembly provides a more efficient and cost-effective alternative to using individual structural steel angles welded to individual steel plate in constructing a marine vessel.
Abstract: Provided in the present invention are recombinant peptides and a method for using the peptides in stimulating an immune response against human high molecular weight-melanoma associated antigen (HMW-MAA). The peptides were designed from the identification of regions of structural and amino acid sequence homology between HMW-MAA and the mouse anti-idiotypic monoclonal antibody MK2-23. The method comprises the step of administering to an individual a peptide of the invention in an amount effective to elicit an immune response against HMW-MAA.
Type:
Grant
Filed:
July 17, 2006
Date of Patent:
February 15, 2011
Assignees:
Health Research, Inc., Hauptman-Woodward Medical Research Institute
Abstract: One step ortho-alkylation of anilines with styrenes to give chiral anilines is obtained using a strong acid catalyst, e.g. CF3SO3H. Condensation of the product to give ligand and metallation gives complex which catalyzes polymerization of propylene to give isotactic propylene or regiorandom propylene of low PDI or blocks thereof, depending on polymerization temperature.
Type:
Grant
Filed:
April 28, 2008
Date of Patent:
February 15, 2011
Assignee:
Cornell Research Foundation, Inc.
Inventors:
Geoffrey W. Coates, Anna Cherian, Jeffrey M. Rose
Abstract: Provided is a method for treatment of blood coagulation disorders. The method comprises administering to an individual compositions comprising lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. One or more peptides, polypeptides or proteins involved in the blood coagulation cascade are associated with the lipidic particles.
Type:
Grant
Filed:
March 30, 2007
Date of Patent:
January 25, 2011
Assignee:
The Research Foundation of State University of New York
Inventors:
Sathy V. Balu-Iyer, Robert M. Straubinger, Razvan Miclea, Aaron Peng
Abstract: Provided are lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.
Type:
Grant
Filed:
March 30, 2007
Date of Patent:
January 25, 2011
Assignee:
The Research Foundation of State University of New York
Inventors:
Sathy V. Balu-Iyer, Robert M. Straubinger, Razvan Miclea, Aaron Peng
Abstract: The method and system of the present invention uses synchronous rectification and frequency domain analysis to remove the need for calibration of the A/D and D/A components. It is applicable to any sensor based measurement in which either the sensor can be excited with an AC voltage or current, or in which the signal can be modulated with an AC voltage or current.
Type:
Grant
Filed:
June 5, 2008
Date of Patent:
January 11, 2011
Assignee:
The Research Foundation of State University of New York
Abstract: A system (100) and a method for the unequivocal allocation of histological cassettes (30) and specimen slides (60) is described. The system encompasses a microtome (1) and at least one reading unit (80). The data (33) of the histological cassette (30) and the data (33) of the at least one specimen slide (60) are read by means of the reading unit (80). The reading unit (80) is provided with at least one indicating element (83) that outputs a signal in accordance with the degree of correspondence between the data (33) of the histological cassette (30) and the data (33) on the specimen slide (60).
Abstract: Biodegradable poly(ester-amides) are synthesized from amino acids, diols and dicarboxylic acids where one or both of the diols and dicarboxylic acids contain unsaturation; e.g., from di-p-nitrophenyl dicarboxylates and p-toluenesulfonic acid salts of bis(alpha-amino acid) disesters of diols where one or both of the dicarboxylate and diol moieties contain unsaturation or from di-p-nitrophenyl dicarboxylates, and p-toluene-sulfonic acid salts of bis(alpha-amino acid) diesters of diols and p-toluenesulfonic acid salt of lysine ester where one or both of the dicarboxylate and diol moieties contain unsaturation. The polymers are useful as biodegradable carriers for drugs of other bioactive agents.
Type:
Grant
Filed:
May 31, 2005
Date of Patent:
January 4, 2011
Assignee:
Cornell Research Foundation, Inc.
Inventors:
Chih-Chang Chu, Ramaz Katsarava, Kai Guo
Abstract: The invention provides compositions and method for stimulating an immunological response against Mycobacterium avium subspecies paratuberculosis (MPT). The compositions comprise at least five recombinant immunogenic components. The immunogenic components can be MPT antigens or DNA polynucleotides encoding MPT antigens, or combinations thereof. MPT antigens used in the invention include MPT 85A, 85B, 85C, 35 kDa, super oxide dismutase (SOD), MptC, MptD and ESAT-6 protein. The method comprises administering the composition to an animal in an amount effective to stimulate an immunological response against MPT bacteria. The method is of benefit to any animal susceptible to MPT infection, but is particularly beneficial for ruminants.
Abstract: The present invention concerns the use of Provided is a drug composition and a method for using the composition for the prevention and the therapy of neurodegenerative diseases. The combination comprises at least two of the following substances: ?-lipoic acid; ambroxol and one or several inhibitor(s) of the angiotension-converting enzyme (ACE).
Type:
Grant
Filed:
January 26, 2004
Date of Patent:
December 28, 2010
Assignee:
Keyneurotek Pharmaceuticals AG
Inventors:
Peter Röhnert, Frank Striggow, Klaus Reymann, Siegfried Ansorge, Michael Täger, Ulrich Schröder
Abstract: Provided are novel tetrahydropyridine derivatives bearing substituents. These compounds can be used for alleviating the symptoms of CNS disorders.
Type:
Grant
Filed:
March 12, 2007
Date of Patent:
December 14, 2010
Assignee:
The Research Foundation of State University of New York
Abstract: Disclosed are methods for alleviating symptoms of neuropsychiatric disorders using tetrahydropyridine derivatives bearing aromatic substituents. The method comprises administering to an individual a tetrahydropyridine derivative bearing aromatic substituents in an amount effective to alleviate symptoms of the neuropsychiatric disorder.
Type:
Grant
Filed:
March 12, 2007
Date of Patent:
December 14, 2010
Assignees:
The Research Foundation of State University of New York, Chakra Biotech Pte Ltd.
Abstract: A modular conveyor belt having longitudinal grooves on the top and bottom of the belt. Pairs of rollers are installed between the links within these grooves such that the rollers do not project over the surface of the belt but are completely integrated into the body. The rollers may be installed directly onto the pivot rods. The belts are supported by rails that enter into the longitudinal grooves to engage with the rollers to carry the belt as it moves. The grooves on the bottom side of the single modules are curved in such a way that the slots form a circle when the belt moves around a sprocket. This configuration allows for steel disks to be installed between the sprockets on the driving and idling shaft. The disks help to support the belt and to improve smooth running of the belts around the sprocket under a high load by taking the radial forces acting when the belt is under high tension.