Abstract: Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R8, R9 and R10, W, X, and Z are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: The present invention controls reagent flow levels in a selective non-catalytic reduction (SNCR) system by more accurately predicting Nitrogen Oxides (NOx) production with a municipal waste combustor. In one embodiment, the reagent levels correspond with measured furnace temperatures. The reagent levels may have a baseline level from prior measured NOx that is then modified according to temperatures measurements. A slow controller may use NOx measurements over an extended period to define a base regent level, and a fast controller may use additional information such as the furnace temperature to modify the base regent level. The fast controller may further receive two additional signals that are added individually or together to maximize NOx control while minimizing ammonia slip from the reagent. The two signals are a feed-forward signal from the combustion controller and a feedback signal from an ammonia analyzer downstream of the combustion zone.

Abstract: A device for adjusting a dual-servo brake with internal shoes (9) being supported on a shoe-holder plate (2) so as perform floating selfreinforcing or automatic activation movements against a braking surface of a drum.

Abstract: A braking band of a disc for a disc brake of the ventilated type, unusually capable of improving the disc cooling efficiency, extends between an inner diameter close to an axis of rotation of the disc and an outer diameter away from the said axis of rotation of the disc. The braking band may have two leaves defining an intermediate space and joined by a connection. The ratio between the outer diameter of the surface and the thickness or maximum dimension of the said intermediate space between the two leaves measured in a direction parallel to the axis of the disc may be between 15 and 32.

Abstract: Disclosed are methods of treating inflammatory diseases and disorders, such as arthritis and inflammatory bowel disease, in mammals.

Abstract: Disclosed are compounds of the Formula III and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 R10, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract: A method for fabricating a magnetic recording head writer. The writer includes a bottom magnetic pole and a write gap formed over the bottom pole and a coil trench formed in the bottom pole. A top magnetic pole is provided as two layers with the first layer including front and back tips with spaced apart walls positioned adjacent the trench bottom defining trench sides. A pole cover layer is included that is made up of a thin layer of insulating material deposited to cover sides and bottom of the coil trench. A bottom coil is formed on the pole cover layer in the bottom of the coil trench and coil insulation is provided between coil elements and adjacent trench walls and covemg the coil. A top coil with insulation is formed over the planarized bottom coil insulation and the top pole second layer is formed over the top coil.

Abstract: The disclosed invention pertains to methods for diagnosing clinical conditions that are common in hemodialysis patients and that may be related to abnormal carnitine metabolism resulting from hemodialysis. Further, the present invention pertains to methods for monitoring and improving the administration of therapeutic intravenous levocarnitine to such patients. Clinical algorithms have been developed for the clinical symptoms seen in end-stage renal disease (ESRD) patients that may be related to carnitine deficiency. Monitoring tools to assist healthcare professionals in implementing the clinical algorithms are also provided.

Abstract: A computer implemented method, a system, and a software product to automatically manage one or more human workers carrying out a process of manipulating source data provided to produce result data. The process including a set of one or more task steps each having an input and resulting in a task result. The computer implemented method includes receiving units of source data from a customer. For each unit of source data and each task step for the unit of source data, the method includes dispatching the task step and its corresponding input unit to a worker and, after the worker carries out the dispatched task step on the input unit, receiving the task result corresponding to the dispatched task step and input unit from the worker.

Abstract: A system and method for managing state information between processes in different domains, and, more particularly, to software, systems and methods for determining and updating state information using hypertext transfer protocol (HTTP) cookies. A state management server manages priority information based on the priority of content requested by a user agent from a number of different domains. In a preferred embodiment, domain-specific state information is collected by a plurality of front-ends operating in dynamically assigned domains, and reported to the state management server which operates in a statically assigned domain. Preferably, the state management server causes the global priority information to be stored on a client device, such as a computer, in the form of a global cookie.

Abstract: A foundation assembly for use with expansive soils. The assembly includes a slab form, such as metal pan, for receiving poured concrete, a structural slab cast into the form, and structural members, e.g., piers, footing pads, and the like, contacting and/or extending into the soil. An elongate support member, e.g., a rectangular concrete beam, is positioned on an upper support surface of the structural members so as to contact a lower surface of the slab form. In this manner, the support member supports the slab form and structural slab and defines a void space between the soil and the slab form without the use of biodegradable materials.

Abstract: A system and method for implementing functionality within a network on behalf of first and second computers communicating with each other through the network. A front-end computer is provided within the network having an interface for communicating data traffic with the first computer. A back-end computer is also implemented within the network having an interface for communicating data traffic with the second computer. A communication channel couples the front-end computer and the back-end computer. Data traffic is encoded over the communication channel in a first process in the front-end computer. Data traffic is also encoded over the communication channel in a second process in the back-end computer, wherein the first process and the second process implement compatible semantics.

Abstract: A system and method for prioritizing sets of information transmitted across a network. The priority of a set of information determines the order in which it is transmitted and other characteristics associated with the set of information, such as connection reliability. In one embodiment, the set of information is a packet, and the packet is prioritized upon receipt by an intermediary network computer. The intermediary transmits packets based on the priority associated with each packet. Priority information includes priority parameters, priority values, parameter valuation information, and weighting algorithms. Priority parameter types and values are based on attributes associated with a set of information, such as user identification and requested content. Priority types and values, which are based on priority parameter types and values, determine a component of the priority associated with a set of information. Parameter valuation information associates priority parameters with priority values.

Abstract: A database system operating over a communication network. A plurality of client applications coupled to the network generate database access requests. An intermediary server coupled to the network receives the requests. A data storage mechanism coupled to the network has an interface for communicating with the intermediary servers. The intermediary server is responsive to a received database access request to establishing a channel with the data storage mechanism to obtain data from the data storage mechanism in response to a received client request. The intermediary server is further operable to format the obtained data in a manner suitable for use by one of the client applications that requested the associated database access.

Abstract: A method of processing a secured loan so as to close the loan in time periods on the order of one hour. The loan process is initiated by accepting a loan application from a borrower. The loan application includes at least the borrower's identity, collateral identity, and stated income of the borrower. A credit request is generated based upon the borrower's identity to obtain a credit report, the credit report including credit information and credit score information. A property evaluation database is accessed using the collateral identity. A matrix having specified approval criteria is applied to generate a credit approval, collateral title underwriting approval, and income approval. Loan documentation is generated and transmitted for signatures at closing.