Abstract: The invention provides a new derivative of vitamin D, 25-hydroxycholecalciferol-26,23-lactone.The compound is characterized by vitamin D-like activity in its ability to increase serum calcium concentration by mobilizing bone and would find application in disease states requiring the elevation of serum calcium concentration.

Abstract: 25-Aza-vitamin D.sub.3, 25-methylvitamin D.sub.3, cholanocalciferol dimethylamide and methods for preparing the same. The compounds are characterized by anti-vitamin D activity and find application where inhibition of the intestinal calcium transport or bone calcium mobilization effects of vitamin D are desirable.

Abstract: 1.alpha.-hydroxycalcioic acid. The compound displays antirachitic (vitamin D-like) activity and would find application in disease states characterized by adverse calcium-phosphorous balance or behavior.

Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors of derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.

Abstract: The invention provides new derivatives of vitamin D, 24,24-difluoro-1.alpha.,25-dihydroxycholecalciferol and 24,24-difluoro-1.alpha.,25-dihydroxy-5,6-trans-cholecalciferol and processes for preparing the same.The compounds are characterized by vitamin D-like activity essentially equivalent to the vitamin D-like activity of 1.alpha.,25-dihydrocholecalciferol which is considered to be the hormonal form and most active derivative of vitamin D. The compounds of this invention are characterized by their ability to increase intestinal calcium transport, increase serum calcium and to prevent the development of rickets. These compounds would find ready application as a substitute for vitamin D and in the treatment of disease states evincing metabolic calcium and phosphorus deficiencies.

Abstract: The invention provides a new derivative of vitamin D.sub.3, 24,24-difluoro-25-hydroxycholecalciferol.The compound is characterized by vitamin D-like activity in its ability to increase intestinal calcium transport, increase serum calcium and inorganic phosphorous concentration and to prevent the development of rickets. It would find ready application as a substitute for vitamin D.sub.3 and in the treatment of disease states evincing calcium-phosphorous imbalance and which are non-responsive to vitamin D.sub.3 therapy.

Abstract: A method for directly introducing an oxygen function at carbon 1 of the vitamin D molecule or precursors or derivatives thereof which comprises subjecting such molecules to allylic oxidation utilizing selenium dioxide as the oxidizing agent.

Abstract: Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.

Abstract: Racemic 15-deoxy, 11,15-deoxy and other prostaglandins and methods for preparing the same. The initial reactant is lithium cyclopentadiene which is reacted with ethyl-7-bromoheptanoate to give the alkylated diene which in turn is oxygenated to a mixture of hydroxycyclopentenones. 2-(6'-carboethoxyhexyl)-4-hydroxy-cyclopenten-1-one is chromatographically recovered from the mixture and reacted with dihydropyran to give the tetrahydropyranyl ether which is then reacted with 1-lithium-1-transoctene in the presence of tri-n-butylphosphine-copper iodide to produce racemic 15-deoxy-prostaglandin E.sub.1 ethyl ester which is chromatographically recovered. The ester is converted to the corresponding prostaglandin by the action of an esterase-producing microorganism.

Abstract: A plasma focus electrode is described which utilizes a cylindrical hollow conductive anode having a concentric cylindrical insulator. This anode is used in conjunction with a lithium vortex cathode in the formation of a plasma focus for the liberation of neutrons from a plasma at the focus.

Abstract: A method for preparing a reagent for primed LD typing which comprises sensitizing purified human blood leukocytes to a secondary proliferative response by incubating them, in vitro, in mixed leukocyte culture, with lymphoblastoid cell lines from homozygous typing cells, or from other cells of specified genetic type homozygous for HLA-D, or other continuous line.

Abstract: A method of treatment and prophylaxsis for milk fever in dairy cattle which comprises administering 1,25-dihydroxycholecalciferol to the cattle.

Abstract: Mono- and di-glycosides of 2,6-bis (hydroxy-phenyl)-3,7-dioxabicyclo [3,3,0] octane and methods for preparing such compounds. The compounds exhibit anti-hypertensive properties.

Abstract: Racemic 15-deoxo, 11,15-deoxy and other prostaglandins and methods for preparing the same. The initial reactant is lithium cyclopentadiene which is reacted with ethyl-7-bromoheptanoate to give the alkylated diene which in turn is oxygenated to a mixture of hydroxycyclopentenones. 2-(6'-carboethoxyhexyl)-4-hydroxy-cyclopenten-1-one is chromatographically recovered from the mixture and reacted with dihydropyran to give the tetrahydropyranyl ether which is then reacted with 1-lithium-1-trans-octene in the presence of tri-n-butylphosphine-copper iodide to produce racemic 15-deoxy-prostaglandin E.sub.1 ethyl ester which is chromatographically recovered. The ester is converted to the corresponding prostaglandin by the action of an esterase-producing microorganism.

Abstract: A graphics panel is disclosed which translates any random trace of a point light source across the panel into voltage indicative of orthogonal components of the displacement of the light source. By means of such electrical signals a replica of the trace of the light source may be generated by a cathode ray tube, X-Y Plotter, or similar analog devices. The display panel is a flat planar structure composed of transparent plastic material having one side rendered opaque. A plurality of photoconductors are arrayed along the peripheral side of the panel and appropriate electrical circuits incorporating the photoconductors convert the current generated thereby into the voltages proportional to the displacement of the light source along orthogonal axes in the plane of the panel.

Abstract: A material handling apparatus having a storage body, a hopper communicating with it through material compacting or crushing means in which said means comprises a cylindrical roller and a substantially planar material-holding tray capable of movement beneath said cylinder in material compacting relationship therewith.

Abstract: A method of and circuitry for correcting gamma ray camera data signals for signal processing circuitry is disclosed. Pulses are artificially generated which replicate the data signals produced at the output of photomultiplier tubes of the gamma ray scintillation camera and are inserted in the gamma ray camera internal processing circuitry in such a manner as to remain distinguishable from the data signals generated by the photomultiplier tubes. By monitoring the number of artificial pulses produced artificially and the number of such pulses actually counted by the data processing circuitry of the gamma scintillation camera, a factor indicative of the losses of scintillation count in the processing circuitry may be determined.

Abstract: An active filtration system is described which may be particularly useful for filtering undesired harmonics of the fundamental AC frequency produced by AC to DC or DC to AC conversion. The filtration system of the invention produces currents of a phase, frequency and magnitude for injection into the AC system such that the undesired harmonic currents to be filtered sum with the injected currents giving a net zero current at the undesired harmonic frequency. The system can incorporate existing passive filtration elements and provides a high-impedance parallel-filtration network to prevent the filteration system from acting as a "sink" for the ambient harmonics generated elsewhere in the AC system. Because the frequency, phase and magnitude of the injected currents are controlled, the filter of the invention remains highly effective even when these quantities and the filter component values vary.

Abstract: A rodenticide suitable for the control of rat and mice populations containing as the active rodenticidal ingredient 1.alpha.-hydroxycholecalciferol or 1.alpha.-hydroxyergocalciferol or 1,25-dihydroxycholecalciferol.

Abstract: A method for stereospecifically preparing chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one which comprises asymmetrically reducing 2-substituted cyclopentane-1,3,4-trione to the corresponding 2-substituted-4(R)-hydroxy-cyclopentane-1,3-dione, enolizing the said dione to obtain the enol ester or enol ether configuration, reducing the enol ester or ether and recovering the desired compound. The chiral 2-substituted-4-hydroxy-2-cyclopenten-1-one are key intermediates in the preparation of prostaglandins.