Patents Represented by Attorney Hoxie & Associates LLC

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  • Pyrazolo-tetrahydro pyridine derivatives as orexin receptor antagonists
    Patent number: 7834028
    Abstract: The invention relates to novel pyrazolo-tetrahydropyridines compounds and their use as orexin receptor antagonists.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: November 16, 2010
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Hamed Aissaoui, Christoph Boss, Markus Gude, Ralf Koberstein, Thierry Sifferlen
  • Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators
    Patent number: 7825260
    Abstract: Compounds of formula I, wherein X, a, b, R1, R2, R3, R4 and R5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: November 2, 2010
    Assignee: Novartis AG
    Inventors: Rainer Albert, Claus Ehrhardt, Peter Ettmayer, Klaus Hinterding, Klemens Högenauer, Peter Nussbaumer
  • Indolylmaleimide derivatives
    Patent number: 7820672
    Abstract: The compounds are indolylmaleimide derivatives comprising either a substituted pyridyl or indolyl residue. The compounds have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, or acute or chronic transplant rejection.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: October 26, 2010
    Assignee: Novartis AG
    Inventors: Peter Von Matt, Jürgen Wagner
  • Process for the preparation of stilbene derivatives
    Patent number: 7820848
    Abstract: A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: October 26, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Ralph Haerter, Ulrike Lemke, Alexander Radspieler
  • Reverse isoxazoles
    Patent number: 7799812
    Abstract: The present invention relates to polycyclic compounds, processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 21, 2010
    Assignee: Novartis AG
    Inventors: Rainer Albert, Frederic Zecri
  • Piperidine carboxylic acid amide derivatives
    Patent number: 7799805
    Abstract: The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such compounds and especially the use of such compounds as inhibitors of renin.
    Type: Grant
    Filed: May 23, 2006
    Date of Patent: September 21, 2010
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Olivier Bezencon, Christoph Boss, Daniel Bur, Austin Chih-Yu Chen, Olivier Corminboeuf, Daniel Dube, Walter Fischli, Corinna Grisostomi, Lubos Remen, Sylvia Richard-Bildstein, Thierry Sifferlen, Michel Therien, Thomas Weller
  • Purified PKB Ser 473 kinase and uses thereof
    Patent number: 7794995
    Abstract: This invention provides purified PKB Ser 473 kinase and methods of purifying it. The methods involve the use of several sequential steps, including subcellular fractionation to isolate a plasma membrane fraction and the use of gel filtration or chromatography that separates molecules according to their size or affinity.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: September 14, 2010
    Assignee: Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
    Inventors: Jianhua Feng, Brian A Hemmings, Michelle M Hill
  • Indolylmaleimide derivatives
    Patent number: 7781438
    Abstract: A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: August 24, 2010
    Assignee: Novartis AG
    Inventors: Jürgen Wagner, Maurice Van Eis, Peter Von Matt, Jean-Pierre Evenou, Walter Schuler
  • Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
    Patent number: 7763638
    Abstract: The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: July 27, 2010
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Hamed Aissaoui, Martine Clozel, Walter Fischli, Ralf Koberstein, Thomas Weller
  • Indol-alanine derivatives as selective S1P4-agonists
    Patent number: 7754896
    Abstract: The present invention relates to agonists of the S1P4 receptor, which are selective for the S1P4 receptor over one or more of the S1P1, S1P2, S1P3 or S1P5 receptors of at least 10 fold, in particular new indol-alanine derivatives of structure I, process for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them wherein R1 is phenyl or naphthyl, wherein phenyl is substituted by one or two of halogen, C1-6alkyl, C1-6alkoxy or phenylC1-6alkyl; and R2 is hydrogen or C1-6alkyl; in free or salt form.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: July 13, 2010
    Assignee: Novartis AG
    Inventors: Kamal Azzaoui, Rochdi Bouhelal, Peter Buehlmayer, Danilo Guerini, Manuel Koller
  • Pyridine derivatives
    Patent number: 7750161
    Abstract: The invention relates to novel pyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
    Type: Grant
    Filed: September 21, 2004
    Date of Patent: July 6, 2010
    Inventors: Daniel Bur, Martine Clozel, Boris Mathys, Claus Mueller, Michael Scherz, Joerg Velker, Thomas Weller
  • Thiophene derivatives
    Patent number: 7750040
    Abstract: The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: July 6, 2010
    Inventors: Martin Bolli, Daniel Bur, Martine Clozel, Walter Fischli, David Lehmann, Boris Mathys, Claus Mueller, Oliver Nayler, Michael Scherz, Thomas Weller
  • Quinuclidine derivatives and medicinal compositions containing the same
    Patent number: 7750023
    Abstract: The invention provides 3-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with ?2 agonist.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: July 6, 2010
    Inventors: María Dolors Fernandez Forner, María Prat Quiñones, María Antonia Buil Albero
  • 2,6-quinolinyl derivatives, processes for preparing them and their uses
    Patent number: 7732614
    Abstract: The present invention concerns 2,6-quinolinyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
    Type: Grant
    Filed: June 9, 2006
    Date of Patent: June 8, 2010
    Assignee: UCB S.A.
    Inventor: Benjamin Perry
  • Amino acid derivatives
    Patent number: 7728020
    Abstract: The present invention relates to new amino acid derivatives, process for the production, their use, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: June 1, 2010
    Assignee: Novartis AG
    Inventors: Klaus Hinterding, Klemens Högenauer
  • Hydrogenated benzo (C) thiophene derivatives as immunomodulators
    Patent number: 7723378
    Abstract: The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds particularly as immunosuppressant agents.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: May 25, 2010
    Assignee: Actelion Pharmaceuticals Ltd.
    Inventors: Martin Bolli, David Lehmann, Boris Mathys, Claus Mueller, Oliver Nayler, Jörg Velker, Thomas Weller
  • Polypeptides and encoding polynucleotides for microbial production of L-ascorbic acid and associated methods
    Patent number: 7700723
    Abstract: The present invention discloses an isolated polynucleotide molecule derived from a polynucleotide encoding a polypeptide having L-sorbosone dehydrogenase activity comprising a partial nucleotide sequence of at least 20 consecutive nucleotides of SEQ ID NO:1. The present invention further relates to a process for the production of L-ascorbic acid in high yield, in particular a process using resting cells of a microorganism able to convert given carbon sources into vitamin C. The thus obtained vitamin C may be further processed by purification and/or separation steps.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: April 20, 2010
    Assignee: DSM IP Assets B.V.
    Inventors: Alan Berry, Connie Lee, Anne Françoise Mayer, Masako Shinjoh
  • Process for the manufacture of alkenylated hydroxylated aromatic compounds, of chroman compounds and of their acylated derivatives
    Patent number: 7696364
    Abstract: The present invention relates to a process for the manufacture of alkenylated aromatic compounds featuring at least one hydroxy group, their ring-closure reactions to 5 chroman derivatives, as well as the acylation of the latter and the aromatic compounds featuring at least one hydroxy group themselves. The present invention relates especially to a process for the manufacture of tocol, tocopherols and their alkanoates such as (x-tocopherol (TCP) and alkanoates (TCPA) thereof, preferably (x-toeopheryl acetate (TCPAc). The processes of the present invention are characterized in that at least one step of the processes is carried out in the presence of an indium salt as the catalyst.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: April 13, 2010
    Assignee: DSM IP Assets B.V. a Netherlands Corporation
    Inventors: Werner Bonrath, Yann Foricher, Thomas Netscher, Angela Wildermann
  • Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator
    Patent number: 7696184
    Abstract: The present invention relates to amino-propanol derivatives, process for their production, their uses in treating and/or preventing diseases or disorders mediated by lymphocyte interactions, and pharmaceutical compositions containing them. For example, Compounds of formula I wherein A, R1, R2, R3, R4 and R5 are as defined in the specification are described.
    Type: Grant
    Filed: June 11, 2004
    Date of Patent: April 13, 2010
    Assignee: Novartis AG
    Inventors: Claus Ehrhardt, Klaus Hinterding
  • Indolymaleimide derivatives
    Patent number: 7691861
    Abstract: A compound of formula I wherein R, Ra, Rb, Rc, Rd and Re are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: April 6, 2010
    Assignee: Novartis AG
    Inventors: Maurice Van Eis, Peter Von Matt, Jürgen Wagner, Jean-Pierre Evenou