Abstract: The invention provides 3 (R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1 -azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with phosphodiesterase 4 inhibitors.
Type:
Grant
Filed:
January 3, 2006
Date of Patent:
May 8, 2007
Assignee:
Almirall AG
Inventors:
Maria Dolors Fernandez Forner, Maria Prat Quiñones, Maria Antonia Buil Albero
Abstract: The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, in association with steroids.
Type:
Grant
Filed:
January 3, 2006
Date of Patent:
March 27, 2007
Assignee:
Almirall Prodesfarma AG
Inventors:
Maria Dolors Fernandez Forner, Maria Prat Quiñones, Maria Antonia Buil Albero
Abstract: The invention relates to the identification and disruption of essential fungal specific genes isolated in the yeast pathogen Candida albicans namely CaKRE5, CaALR1, and CaCDC24 and to the use thereof in antifungal diagnosis and as essential antifungal targets in a fungal species for antifungal drug discovery. More specifically, the invention relates to the CaKRE5, CaALR1, and CaCDC24 genes, to their use to screen for antifungal compounds and to the drugs identified by such.
Type:
Grant
Filed:
May 5, 2000
Date of Patent:
October 31, 2006
Assignee:
McGill University
Inventors:
Terry Roemer, Howard Bussey, John Davison
Abstract: Compounds of the formula wherein: {circle around (C)} is phenyl, C4 to C9 heteroaromatic, naphthalenyl, 5,6,7,8-tetrahydronaphthalenyl or biphenyl; R1, R2 and R3 are hydrogen or a substituent; n is 0 to 4; A represents —CH2—, —CH?CR6, —CR6?CH—, —CR6R7—, —CO—, —O—, —S—, —S(O)—, SO2 or —NR6—, wherein R6 and R7 are hydrogen or lower alkyl, or R6 and R7 together form an alicyclic ring; m is 0 to 8; (when m=0, A is not —CH2—); p is 1 or 2; B represents a group of the formula ii): wherein R10 is hydrogen, hydroxy or methyl; and Q represents a single bond, —CH2—, —CH2—CH2—, —O—, —O—CH2—, —S—, —S—CH2— or —CH?CH—, and x represents an anion and wherein the compounds show high affinity for muscarinic M3 receptors (Hm3).
Type:
Grant
Filed:
December 17, 2003
Date of Patent:
September 19, 2006
Assignee:
Almirall Prodesfarma AG
Inventors:
Maria Dolors Fernandez Forner, Maria Prat Quiñones, Maria Antonia Buil Albero
Abstract: The invention provides 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2] octane in salt form, pharmaceutical compositions comprising it, and methods of using it for treatment of respiratory disorders, alone or in combination with other bronchodilatory compounds.
Type:
Grant
Filed:
April 28, 2005
Date of Patent:
July 18, 2006
Assignee:
Almirall Prodesfarma AG
Inventors:
Maria Dolors Fernandez Forner, Maria Prat Quiñones, Maria Antonia Buil Albero