Abstract: Binding compositions and various methods of use of the binding compositions are provided. In particular, a method is provided which comprises administering an effective amount of the binding composition, alone or in combination with other compounds, to eosinophils, thereby reducing the level of eosinophils in an individual. Preferably, the binding composition is a monoclonal antibody specific for CCR3.
Type:
Grant
Filed:
May 6, 1998
Date of Patent:
March 27, 2001
Assignee:
Schering Corporation
Inventors:
J. Christopher Grimaldi, Maureen C. Howard, Robert L. Coffman