Patents Represented by Attorney, Agent or Law Firm Human Genomes Sciences, Inc.
  • Human tissue inhibitor of metalloproteinase-4
    Patent number: 6448042
    Abstract: A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 10, 2002
    Assignee: Human Genome Sciences, Inc.
    Inventors: John M. Greene, Craig A. Rosen