Abstract: A medical guide wire (1) is made in which at least a fluororesin coating layer (13) is formed on the surface of a metal wire (11), wherein particulate matter is present in the fluororesin coating layer (13), and the fluororesin coating layer covers the particulate matter and at least some of the particulate matter is formed in surface protrusion-shaped projections (14). It is thus possible to provide a medical guide wire that is inexpensive to manufacture and whose strength is unaffected and frictional resistance is low, and manufacturing method for the same.