Abstract: A composition comprising a polypeptide and an active agent covalently attached to the polypeptide. Also provided is a method for delivery of an active agent to a patient comprising administering to the patient a composition comprising a polypeptide and an active agent covalently attached to the polypeptide. Also provided is a method for protecting an active agent from degradation comprising covalently attaching the active agent to a polypeptide. Also provided is a method for controlling release of an active agent from a composition comprising covalently attaching the active agent to the polypeptide.
Type:
Grant
Filed:
August 22, 2000
Date of Patent:
April 6, 2004
Assignee:
New River Pharmaceuticals Inc.
Inventors:
Thomas Piccariello, Lawrence P. Olon, Randall J. Kirk