Abstract: Using adaptions of option pricing techniques from the financial industry, the invention provides systems and methods for structured development of migration options in a legacy transactional enterprise. Components and risk factors of the legacy enterprise are identified and determined, as well as components and risk factors of unmet opportunities, and potential components for the enterprise. Migration options for the enterprise are developed using the components and risk factors.

Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

Abstract: The invention relates to novel benzimidazole and imidazopyridine derivatives having general formula (I), which have a good affinity with certain sub-types of melanocortin receptors, particularly MC4 receptors. Said derivatives are particularly suitable for the treatment of pathological states and diseases involving one or more melanocortin receptors. The invention also relates to pharmaceutical compositions containing said products.

Abstract: A hand held vacuum cleaner having a housing, a motor-fan unit, a dust container, an air passage opening into the dust container and through which dust laden air is directed into the dust container, and at least one filter arranged after the dust container, as seen in the flow direction. The dust container has a first emptying opening, which is normally being covered by a lid and is sized such that it allows the dust collected in the dust container to fall out through the opening when the lid is opened. The dust container also has a second emptying opening. In one aspect, the second emptying opening is adapted to be fluidly connected to an external vacuum source via a connection. In another aspect, a similar device is provided, and adapted so the dust container can be emptied through the first emptying opening without removing the dust container from the vacuum cleaner.

Abstract: An apparatus, system, and method for removing sediment from water is disclosed. According to one embodiment of the present invention, the apparatus includes a tubular filter assembly comprising a support member; and a filtratable element surrounding the support member, the filtratable element comprising a backing mesh; and a fibrous batting. A system for removing sediment from water is disclosed. According to one embodiment, the system includes a filter chamber to receive a liquid having suspended particles therein; at least one filtration cartridge housed within the filter chamber, wherein the filtration cartridge comprises at least one elongated filtratable element, each filtratable element comprising a support member, and a filtratable media adapted to surround the inner core. A method for removing sediment from water is disclosed.

Abstract: The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands that modulate the activation of the hT250 taste receptor. These compounds potentially may be used as additives in foods, beverages and medicinals for modifying (blocking) hT2R50-associated bitter taste.

Abstract: A semiconductor device with an integrated circuit on a semiconductor substrate comprises a Hall effect sensor in a first active region and a lateral high voltage MOS transistor in a second active region. The semiconductor device of the present invention is characterized in that the structure of the integrated Hall effect sensor is strongly related with the structure of a high-voltage DMOS transistor. The integrated Hall effect sensor is in some features similar to a per se known high-voltage DMOS transistor having a double RESURF structure. The control contacts of the Hall effect sensor correspond to the source and drain contacts of the high-voltage DMOS transistor. The semiconductor device of the present invention allows a simplification of the process integration.

Abstract: The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, 5 upon binding of KIR to its HLA class I ligand, can involve a ligand-binding induced, conformational reorientation of the KIR molecules allowing interactions to form between adjacent KIRs in specific domains, leading to accelerated clustering. Methods and agents such as mono-clonal antibodies for reducing KIR-mediated inhibition of NK cell cytotoxicity without reducing or blocking HLA-binding by, e.g., reducing or blocking dimerization of KIR, are provided.

Abstract: Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the expression of a desired structural gene, e.g., a mammalian polypeptide. Particularly preferred is the use of these novel promoters to regulate gene expression in polyploidal yeast such as diploidal P. pastoris produced by mating or spheroplast fusion.

Abstract: A system that facilitates opening of a bank account by banking personnel for a customer. The account opening system includes an automatic rate determination feature that uses customer information, account information and other criteria to determine an account interest rate. The rate determination system may also mediate rate negotiation between a personal banker and the customer by limiting the increase in rate awarded by the personal banker. An auditing system assigns numbers to a series of profiles, each describing a request to open an account. Profiles to be audited are determined by generating random numbers that fall within the range of assigned profile numbers. Random number generation is repeated until a threshold percentage of profiles have been selected for auditing. The account opening system includes a system for tracking the progress of the account application and for organizing information recorded by the personal banker during interactions with the customer.

Abstract: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli. Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions.

Abstract: The invention relates to process for the treatment of a hydrophobic surface by a liquid film comprising an aqueous phase comprising the coating of said surface by the liquid whose aqueous phase comprises an effective amount of surface properties modifying agent and an active agent.

Abstract: The present invention relates to a bio-stable hydrogel for use in the treatment and prevention of incontinence and vesicouretal reflux. The hydrogel is obtainable by combining acrylamide and methylene bis-acrylamide in amounts to provide about 0.5 to 25% by weight polyacrylamide, based on the total weight of the hydrogel.

Abstract: A depolymerized-carboxyalkyl polysaccharide formed by de polymerizing a polysaccharide having from 0.5 to 3.0 degrees of substitution and reducing the molecular weight of said polysaccharide before or after said depolymerizing provides a biodegradable scale inhibitor useful to prevent deposition of scale comprising, for example, calcium, barium, sulfate and salts thereof. The depolymerized carboxyalkyl polysaccharide is particularly useful in off shore oil production squeeze treatments and in the treatment of scale formed in industrial water treatment.

Abstract: The invention relates to compounds of formula (I) wherein U, V, W, X, R1, R2, R3, R4, R5, R6, A, B, D, E, G, m, and n are as defined in the description, to pharmaceutically acceptable salts of such compounds for use in the manufacture of a medicament for the prevention or treatment of a bacterial infection. Certain compounds of formula (I) are new and are also part of this invention.

Abstract: The invention relates to a method for preparing acrylic acid from an aqueous glycerol solution, comprising a first step of dehydration of the glycerol to acrolein, carried out in the gas phase in the presence of a catalyst and under a pressure of between 1 and 5 bar, and a second step of oxidation of the acrolein to acrylic acid, in which an intermediate step is implemented, consisting in at least partly condensing the water and heavy by-products present in the stream issuing from the first dehydration step. This method serves to obtain high acrylic acid productivity and selectivity.

Abstract: A recording apparatus including a printing unit that contacts or separates a thermal head with or from a platen using the driving force of a UD motor, one or more sheet feed units that include sheet feed rollers which are rotated forward or backward by the driving force of an LF motor transmitted through a transport gear group and pressure rollers which are supported between a pair of roller supporting members and are urged by elastic members to come into pressure contact with the sheet feed rollers, and are provided on an upstream side and a downstream side of the printing unit in a transport path of a recording sheet, a pressure release mechanism including a cam shaft that is rotatably provided so as to tilt the pair of roller supporting members of the sheet feed units against the urging force of the elastic members and separates the pressure rollers from the sheet feed rollers, and a pressure release gear group that transmits the driving force of the LF motor to the cam shaft of the pressure release mechan

Abstract: The invention relates to antibacterial compounds of formula I wherein R1 represents alkoxy (notably methoxy); R2 represents H or F; each of R3, R4, R5 and R6 represents independently H or D; V represents CH and W represents CH or N, or V represents N and W represents CH; Y represents CH or N; Z represents O, S or CH2; and A represents CH2, CH2CH2 or CD2CD2; and salts of such compounds.