Abstract: The invention relates to a vial for a liquid or pasty cosmetic product, comprising an elongate body having a base area (11) and a free edge (12), a vessel (20) containing said product and which is translatably movable in the body between a bottom rest position and a top working position, an elastically compressible guide device with a stable retracted configuration determining the bottom position and a maximum extension configuration determining the top position, comprising a hollow guide track in which a guide pin is inserted at least in the maximum extension configuration, as well as an application element (30) comprising a cap (40) suitable for being inserted inside the body and, in the opposite direction, for being at least partially extracted from said body by the elastically compressible guide device.

Abstract: The invention relates to novel pyrimido-benzimidazole derivatives. Said products exhibit a good affinity for certain melanocortin receptor sub-types, in particular MC4 receptors. Said products represent a particular interest for treating pathological disorders and diseases associated with one or several melanocortin receptors. Pharmaceutical compositions containing said products and the use thereof for a drug preparation are also disclosed.

Abstract: The invention relates to aminopyrazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

Abstract: A method and system of the present invention are directed to expediting payments for scheduled delivery (e.g., next day delivery) to various payees or recipients. A computer implemented method and system for expediting payments may include receiving recipient data and payment data from a customer at a remote location; wherein recipient data comprises recipient identifier and payment data comprises payment type; obtaining a payment instrument based at least in part on the payment data; debiting an amount of the payment instrument from an account identified by the customer; and delivering the payment instrument to a facility; wherein the facility delivers the payment instrument to a recipient identified by the recipient data entered by the customer.

Abstract: The invention relates to a vial for a liquid or pasty cosmetic product, comprising: an elongate body (10), extending in a longitudinal direction, a vessel containing said product and which is translatably movable inside the body, an application element (30) comprising a rod (31) rigidly connected to a cap (40) and ending in an applicator (32) suitable for being loaded with the product when dunked into the vessel, said cap being insertable into/onto the body by pushing said application element into the vessel up to a rest configuration and extractable from said body so as to extract the rod and the applicator from the vessel and from the body, and complementary sealing means (35 and 80) designed for translatably coupling the rod and the vessel in a relative sealing configuration, characterized in that the top position of the vessel in the body is defined by complementary retaining elements designed so as to generate a resistance against the downward movement of the vessel in the body from said top position, th

Abstract: A system for removing sediment from water is disclosed. The exemplary embodiments described herein disclose a system comprising a filter chamber, having a deck positioned inside to divide it into an upper chamber and a lower chamber. The deck may have a plurality of holes to hold filtration elements and also may have a ridge or a skirt or both. An inlet line may be tangentially connected to the filter chamber and introduce influent liquid into the filter chamber below the deck and outside of the skirt.

Abstract: A method for improving the distribution of agriculturally active ingredients on the surface of granules includes preparing a sprayable liquid solution of at least one agriculturally active ingredient, and applying the sprayable liquid solution on the granules by spraying the liquid solution in atomized form onto the surface of the granules to provide a coating on the surface of the granules which enables substantially all of the agriculturally active ingredient on the granule to be solubilized by the naturally occurring moisture present on the foliage of a treated weed for absorption into the cells of the treated weed when the granules are applied thereto.

Abstract: The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and ? is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.

Abstract: A method and system of the present invention are directed to expediting payments for scheduled delivery (e.g., same day delivery, next day delivery) to various payees or recipients. A computer implemented method and system for expediting payments may include receiving recipient data and payment data from a customer at a remote location; wherein recipient data comprises recipient identifier and payment data comprises payment type and delivery time; obtaining a payment instrument based at least in part on the payment data; debiting an amount of the payment instrument from an account identified by the customer; and delivering the payment instrument to a facility; wherein the facility delivers the payment instrument to a recipient identified by the recipient data entered by the customer.

Abstract: A defragmentation method includes the steps of: a) configuring a processor to determine a type of a target machine-readable storage device coupled electrically to the processor; b) configuring the processor to select, from among a plurality of pre-established defragmentation algorithms respectively for performing defragmentation on different types of machine-readable storage devices, a defragmentation algorithm that corresponds to the type of the target machine-readable storage device as determined in step a); and c) configuring the processor to perform defragmentation on the target machine-readable storage device according to the defragmentation algorithm as selected in step b).

Abstract: A system for transferring funds to pay bills and to and from selected accounts on an optimized is provided. A mediation engine may manage the payments made to selected payees, including by scheduling the payments and selecting sources for funds. A rules-based optimizer may automatically select the least-cost or other most efficient or desirable transaction, given the customer's available funds, types of funds and payment date. All payment providers and payees may manipulated using one seamless view. A customer service representative may also view the transfers.

Abstract: The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in diseases associated with abnormal blood coagulation or fibrinolysis. In preferred embodiments these patients will comprise those exhibiting elevated D-dimer or other coagulation cascade related proteins and optionally will further exhibit elevated C reactive protein prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, et al.

Abstract: The present invention relates to input devices and particularly to input devices for use with computer and telecommunications systems and/or other object systems and/or devices. More particularly, the present invention relates to a universal input device for inputting data.

Abstract: A remote water meter monitoring system is provided. A mesh network-type transceiver unit is coupled to a water meter housing having a water counting mechanism inside to transmit water consumption information as well as other sensor information, such as backflow detection, water pressure, and water metrics (e.g., residual chlorine and temperature) to a central server system via a bridge device and a corresponding mesh network. Mechanical energy from the water flowing through the water meter housing is converted to electrical energy via an energy conversion unit. An electrically powered shut off valve is remote addressable via the transceiver unit.

Abstract: A system for and method of using a financial instrument to take a view on a price-to-earnings ratio for a set of one or more equities. The system and method may be used to commodify the price-to-earnings ratio for one or more equities, such as a stock or an index. The system and method may include a financial instrument that allows a user to take a view on an earnings, or ratio comprising price and earnings, for underlying equities.

Abstract: A description is given of a method for producing isolation trenches (32, 34) with different sidewall dopings on a silicon-based substrate wafer for use in the trench-isolated smart power technology. In this case, a first trench (32) having a first width and a second trench (34) having a second width which is greater than the first width are formed using a hard mask (30). The sidewalls of the first and second trenches are doped in accordance with a first doping type in order to produce sidewalls having a first doping. A material layer (50, 51, 60, 61) is deposited with a thickness determined so as to fill the first trench (32) completely up to and beyond the hard mask and to maintain the gap (34a) in the second trench (34). By means of isotropic etching the material layer is removed from the second trench, but residual material of the material layer is maintained in the first trench.

Abstract: Methods for obtaining pluripotent (embryonic stem) cells from parthenogenetic embryos, especially primates, are provided. These cells are useful for producing differentiated cells, tissues and organs, especially human and non-human primate cells, tissues and organs.

Abstract: The invention relates to 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives and their use as potent “chemoattractant receptor-homologous molecule expressed on Th2 cells” antagonists in the treatment of prostaglandin mediated diseases, to pharmaceutical compositions containing these derivatives and to processes for their preparation.

Abstract: The invention relates to a notched spatula applicator (1) including gripping means (3) connected to a spatula (2) of which the straight working edge (2c) is equipped with a plurality of notches (4) that are identical and evenly spaced apart by a distance between 35 and 50 mm, the width of said notches being between 9 and 18 mm and their height between 8 and 20 mm. The invention also relates to a process for laying, by bonding, rigid floorcoverings, especially parquet, which uses said applicator and an adhesive composition comprising from 0.2 to 5 wt % of substantially spherical particles of a material for which the substantially identical diameter may range from 1 to 7 mm. The invention finally relates to the adhesive composition used in said process.

Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.