Patents Represented by Attorney Ian C. McLeod

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  • Methods of making nanocomposites and compositions of rubber toughened polyhydroxyalkanoates
    Patent number: 7420011
    Abstract: Toughened compositions from polyhydroxyalkanoate (PHA), preferably PHB reactively blended with maleated poly butadiene and with an epoxidized natural or synthetic rubber are described. The compositions preferably include clay nanoparticles which can be organically modified and can be exfoliated by the blend. The compositions can be used in a variety of applications, including automotive uses.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: September 2, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Amar K. Mohanty, Yashodhan Parulekar
  • Vaccine to control equine protozoal myeloencephalitis in horses
    Patent number: 7419668
    Abstract: The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona.
    Type: Grant
    Filed: February 24, 2000
    Date of Patent: September 2, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable
  • Method for imaging diffusion anisotropy and diffusion gradient simultaneously
    Patent number: 7411394
    Abstract: Inhomogeneous tissue structures cause spatial-varying water molecule diffusion that is characterized by the spatial derivative of diffusivity, i.e., diffusion gradient. In a magnetic resonance imaging (MRI) system, the effects of diffusion and diffusion gradient are simultaneously encoded in an echo signal using diffusion-encoding magnetic field gradient pulses. A method for imaging the diffusion gradient of water molecules in tissues and for delineating the interface between two tissues having different diffusion properties is disclosed. The method also describes imaging diffusion anisotropy and diffusion gradient simultaneously without any additional scans in comparison with diffusion tensor MRI.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: August 12, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventor: Jie Huang
  • Method for the removal of arsenic ions from water
    Patent number: 7404901
    Abstract: A method for the removal of arsenic ions from water with a porous silica composition with an organofunctional moiety comprising a thio which binds the arsenic ion and is then removed from the water. The method comprises the quality of the water.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: July 29, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Thomas J. Pinnavaia, Joel I. Dulebohn, Emily J. McKimmy
  • Process for the preparation of oxazolidinones and method of use thereof
    Patent number: 7390825
    Abstract: Substituted oxazolidinone of the formula: wherein R2 is alkyl selected from the group consisting of methyl, ethyl, and isopropyl moieties, are described. The compounds are antibacterial.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: June 24, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Guijun Wang, Raghavakaimal Padmakumar, Jianmin Mao, Huiping Zhang, Zongmin Dai, Kanakamma Puthuparampil
  • Vaccine to control equine protozoal myeloencephalitis in horses
    Patent number: 7390492
    Abstract: The present invention provides vaccines and methods for making the vaccines that actively or passively protect an equid or other animal against Sarcocystis neurona. In particular, the present invention provides vaccines that provide active immunity which comprise a polypeptide or DNA vaccine that contains or expresses at least one epitope of an antigen that has an amino acid sequence substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona. The present invention further provides a vaccine that provides passive immunity to Sarcocystis neurona comprising polyclonal or monoclonal antibodies against at least one epitope of an antigen substantially similar to a unique 16 (±4) kDa antigen and/or 30 (±4) kDa antigen of Sarcocystis neurona.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: June 24, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Linda S. Mansfield, Mary G. Rossano, Alice J. Murphy, Ruth A. Vrable
  • Transgenic plants containing ligninase and cellulase which degrade lignin and cellulose to fermentable sugars
    Patent number: 7371926
    Abstract: The present invention provides transgenic plants which after harvest degrade the lignin and cellulose therein to fermentable sugars which can further be fermented to ethanol or other products. In particular, the transgenic plants comprise ligninase and cellulase genes from microbes operably linked to a DNA encoding a signal peptide which targets the fusion polypeptide produced therefrom to an organelle of the plant, in particular the chloroplasts. When the transgenic plants are harvested, the plants are ground to release the ligninase and cellulase which then degrade the lignin and cellulose of the transgenic plants to produce the fermentable sugars.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: May 13, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Masomeh B. Sticklen, Bruce E. Dale, Shahina B. Maqbool
  • Biodiesel additive and method of preparation thereof
    Patent number: 7367995
    Abstract: Fuel oxygenates comprised of fatty acid or fatty acid ester derivatives which have been reacted with ozone; a base; and a lower alkanol (1 to 8 carbon atoms) are described. The oxygenates comprise ester groups at a point of cleavage by the ozone which provide oxygen in the oxygenate.
    Type: Grant
    Filed: February 27, 2006
    Date of Patent: May 6, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramani Narayan, Daniel Graiver, Kenneth W. Farminer
  • Copolymerization of 1,4-dioxan-2-one and a cyclic ester monomer producing thermal stabilized 1,4-dioxan-2-one (co)polymers
    Patent number: 7361727
    Abstract: A polymerization process to derive a thermal-stabilized poly(1,4-dioxan-2-one) and cyclic ester monomer copolymer using a coordination-insertion catalyst/initiator. 1,4-dioxan-2-one and cyclic ester monomer, each containing less than 100-ppm water and having an acid value less than 0.5 mg KOH/g, and preferably less than 0.2 mg KOH/g, are copolymerized. Preferably the cyclic ester monomer is ?-caprolactone and the reaction is in an extruder.
    Type: Grant
    Filed: August 8, 2005
    Date of Patent: April 22, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Ramani Narayan, Jean-Marie Raquez, Sunder Balakrishnan, Philippe Dubois, Philippe Degee
  • Epitaxial ferromagnetic NiFeN
    Patent number: 7354505
    Abstract: An epitaxial Ni3FeN film with unique magnetic properties such as single magnetic domain (even in a large scale 0.5?×0.5?), which rotates coherently in response to the desired switching field with a very sharp transition is described. The magnetic hysteresis loop of this new magnetic nitride is close to the perfect ideal square with the same value of saturation magnetization, remnant magnetization, and magnetization right before switching (domain reversal). The switching field is tunable which make this material more attractive for magneto-resistive devices such as MRAM's, read heads and magnetic sensors.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: April 8, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventor: Reza Loloee
  • Carrier-free composition for the treatment of onychomycosis
    Patent number: 7341747
    Abstract: A composition for the treatment of onychomycosis (fungal nail disease) is described. The composition consists essentially of thymol, camphor, menthol and Eucalyptus citridiora as a colorless liquid oil without any carrier or solvent for these ingredients.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: March 11, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventor: Muraleedharan G. Nair
  • 2-thiaquinolizidines and process for the preparation thereof
    Patent number: 7342010
    Abstract: A process for producing 2-thiaquiolizidines which are glycosidase and glycosyltransferase inhibitors is described. The compounds are of the formula: where x is 0 to 3.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: March 11, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Rawle I. Hollingsworth, Li Gao
  • Method for the degradation of MTBE and TBA
    Patent number: 7341863
    Abstract: A method for the degradation of methyl-tertiary-butyl-ether (MTBE) and tertiary-butanol (TBA) using a mixture of Pseudomonas putida is described. The method enables almost complete remediation of MTBE and TBA in situ in contaminated water and/or soil.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: March 11, 2008
    Assignee: Osprey Biotechnics, Inc.
    Inventor: Peter A. Vandenbergh
  • Preparation of hymenialdsine derivatives and use thereof
    Patent number: 7335769
    Abstract: The synthesis and biological activity of indoloazepines and acid amine salts thereof which are structurally related to naturally-occurring hymenialdisine is disclosed. Naturally-occurring hymenialdisine obtained from the sponge is a potent inhibitor of production of cytokines interleukin-2 (IL-2) and tumor necrosis factor-? (TNF-?). The chemically-synthesized indoloazepines of the invention also inhibit production of IL-2 and TNF-?. The indoloazepines are useful for treating inflammatory diseases, particularly diseases associated with kinases NF-?B or GSK-3? activation or NF-?B activated gene expression products. The indoloazepines are useful for the treatment of cancer by the inhibition of kinases CHK1 and CHK2.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: February 26, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventor: Jetze J. Tepe
  • Catalytic boronate ester synthesis from boron reagents and hydrocarbons
    Patent number: 7329769
    Abstract: A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: February 12, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventor: Milton R. Smith, III
  • Piezoimmunosensor
    Patent number: 7329536
    Abstract: An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single VH chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: February 12, 2008
    Assignees: Oakland University, Vanderbilt University
    Inventors: Xiangqun Zeng, Gabrielle Stryker, Raymond L. Mernaugh
  • Process for production of a composition useful as a fuel
    Patent number: 7321052
    Abstract: A process for the preparation of a fuel oil (diesel fuel or heating oil) composition which is a mixture of an alkanol tranesterified fatty acid ester triglyceride and an acetal of glycerol is described. The process preferably provides a prestep of the formation of at least some of the alkanol transesterified triglyceride containing the glycerol for use in the formation of the acetal of glycerol. The composition can also be formed from a reaction of 1,1-dimethoxy- or 1,1-diethoxyethane and glycerol to form the acetal in the alkanol transesterified triglyceride.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: January 22, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Dennis J. Miller, Lars Peereboom, Aspi K. Kolah, Navinchandra S. Asthana, Carl T. Lira
  • Fluid distribution and collection in landfills and contaminated sites
    Patent number: 7309189
    Abstract: A fluid injection and removal system to inject or remove fluids from a landfill or contaminated area. The system allows for treatment of waste in the landfill or the contaminated area. The fluid injection and removal system includes a permeable layer and at least one perforated pipe. The permeable layer enables essentially uniform distribution of the fluid into the underlying waste or contaminated area. The fluid injection and removal system can be combined with a leachate collection system to create a leachate recirculation system for use in a landfill. The leachate collection system includes at least one perforated collection pipe embedded in a drainage layer. Sensors can be provided in the permeable layer to enable the change in the physical characteristics of the waste adjacent the permeable layer to be monitored.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: December 18, 2007
    Assignee: Board of Trustees of Michigan State University
    Inventor: Milind V. Khire
  • Hydroformed port liner
    Patent number: 7305763
    Abstract: A cylinder head (10) for an internal combustion engine has hydroformed port liners (18) positioned within selected ports, either exhaust and/or intake ports (14, 16). The hydroformed port liner (18) includes an air gap (24) for an insulation layer within the selected port (14, 16) between an outer surface (19) of the hydroformed port liner (18) and the wall of the port (14, 16). A cylinder head (12) with a predetermined port configuration has selected ports (14, 16) cast with protrusions (22). The selected ports (14,16) have a larger diameter than a standard size port diameter for that cylinder head to provide a predetermined port configuration by a preset amount based on the thickness of the hydroformed port liner (18) and a desired air gap (22). Protrusions (22) in the wall of the selected ports (14, 16) or on the insert sleeves (17) facilitate formation of the air gap during the hydroforming process.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: December 11, 2007
    Assignee: Board of Trustees of Michigan State University
    Inventors: David Gerard Genise, Suzanne M. Zampaloni, Andrew P. Harman, Michael A. Zampaloni, Farhang Pourboghrat
  • Vacuum flask
    Patent number: D572070
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: July 1, 2008
    Assignee: Phoenix Vacuum Flask Company Ltd
    Inventor: Frank Huang Teh-hsiung