Patents Represented by Attorney, Agent or Law Firm Ian Robert Silverman
  • Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
    Patent number: 6201118
    Abstract: The invention relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of that process step in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: March 13, 2001
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Andrea L. C. Robidoux, Jeffrey Douglas Wilson, Petra Dietrich, Neil Storer, Stefania Leonardi
  • Process for synthesizing piperazic acid
    Patent number: 6177565
    Abstract: The invention relates to a process for synthesizing piperazic acid and similar, ring-containing acids. The invention also relates to a process for simultaneously N(2)-acylating piperazic acid or an ester thereof and forming a bicyclic ring structure. The invention also relates to the use of either or both processes in a method of synthesizing a bicyclic compound useful as an intermediate for the production of an inhibitor of a caspase, particularly an inhibitor of interleukin-1&bgr; converting enzyme (“ICE”).
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: January 23, 2001
    Assignee: Vertex Pharmaceuticals Inc.
    Inventor: Andrea L. C. Robidoux