Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compounds of formula having the structure: wherein R1, R2, and X Y, Z, Ar and n are as described in the specification.

Abstract: Tile vent for covering the opening of the ridge of an undulating roof. The tile vent includes two unitary panels facing each other in a mirror image fashion the top portion of which is affixed to a ridge board and the bottom portion of which is affixed to the undulating roof. The tile vent includes vent slots to allow exhaust of attic air, and reinforcing stiffeners to support ridge tiles placed over the opening in the ridge.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: Method for enhancing the immune system of a patient by orally administering to the patient safflower seeds or an extract of safflower seeds in combination with a pharmaceutically acceptable vehicle.

Abstract: Method and apparatus for measuring the breakaway and running forces required to move the plunger from its initial position toward the distal end of the syringe or cartridge barrel.

Abstract: Universal connector designed for use in various containers having a fluid port for access to the content of the container or for transferring fluid into the container. The universal connector incorporates an elastomeric membrane capable of being ruptured by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means.

Abstract: Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the &agr;, &ggr;, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Abstract: A syringe for injecting a medical fluid into a site or withdrawing a medical fluid from a site, having a syringe barrel and an elastomeric plunger. The syringe barrel is of polymeric material having an inner surface defining a tapered cylindrical chamber extending from the proximal end to the distal end of the syringe. The distal end terminates in a tip, having a bore therethrough, to which an injection needle or a connector is attached. The proximal end receives the slidably insertable elastomeric plunger for reciprocating movement in the tapered cylindrical chamber. The elastomeric plunger is tapered from its proximal end to its distal end. The angle of taper in both the cylindrical chamber and in the elastomeric plunger is at least ⅛°.

Abstract: Algae-resistant roofing granules coated with: a first coat consisting of a fired silicate-clay matrix containing cuprous oxide and zinc sulfide to provide a slow, long-term bimetallic copper and zinc ions release; and a second coat consisting of a fired silicate-clay matrix containing a pigment.

Abstract: A self-aligning reinforced plunger rod and a non-elastomeric plastic plunger insert assembly for use with an elastomeric plunger in a cartridge or syringe barrel, the plunger rod having a first, second, third and fourth sides, a distal end with an end disc, a proximal end with a thumb rest, a central reinforcing disc at the midpoint between the end disc and the thumb rest, and a plunger rod tip integral with the end disc and having a neck portion and a ball portion for engagement with a cavity in the non-elastomeric plastic plunger insert.

Abstract: A tamper evident protector cap for a pre-filled syringe or cartridge barrel stoppered by an elastomeric closure. The protector cap securely retains the elastomeric closure during in-line processing, handling and shipment. The protector cap includes frangible brackets which on tampering break away from the protector cap evidencing that product integrity might have been jeopardized and the product should not be used.

Abstract: Dimensionally stable plunger rod for use with a plunger in a cartridge or syringe barrel for manual or power-assisted withdrawal of fluid from a site or expelling fluid from the cartridge or syringe barrel having: a plunger rod body with a distal and a proximal end; an end disc at the distal end; a threaded member integral with the end disc designed to engage a plunger; a thumb rest at the proximal end; a central disc at the mid point between the end disc and the thumb rest to provide additional reinforcement to the plunger rod; four longitudinal radially extending rectangular vanes connected to the end disc at the distal end, to the central disc at the mid point, and to the thumb rest at the proximal end; two pairs of longitudinal radially extending reinforcing vanes forming two triangular configurations with one of the longitudinal radially extending rectangular vanes on one side of the plunger rod body; and two pairs of longitudinal radially extending reinforcing vanes forming two triangular config

Abstract: A self-aligning plunger rod and a non-elastomeric plastic plunger insert assembly for use with an elastomeric plunger in a cartridge or syringe barrel for manual or power-assisted withdrawing of fluid from a site or expelling fluid from the cartridge or syringe barrel.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: Apparatus and process for coating a continuously advancing web with a dry or wet coating material on a conveyor belt. The apparatus having a hopper which contains an agitator, a brush and a knurled roll to accurately dispense the coating material to an applicator which is positioned on a carousel. By rotating the carousel, the coating in the form of stripes, bars or a uniform layer can be varied at angles 0° to 90° on the continuously advancing web.

Abstract: Single use universal connector, flexible medical container assembly for the containment and delivery of medical fluid having three access means: a single use universal connector access means for luer connection, needle or spike piercing; a needle access means and a spike access means.

Abstract: Multiple use universal connector designed for use in various containers having a fluid port for accessing to the content of the container or for transferring fluid into the container. The multiple use universal connector incorporates a diaphragm capable of being penetrated repeatedly by an access means such as a luer connector or a syringe having a sharp or blunt cannula for fluid communication between the content of the container and the access means. The multiple use universal connector re-seals itself after being penetrated and the access means removed therefrom.

Abstract: Dimensionally stable plunger rod for use with a plunger in a cartridge or syringe barrel for manual or power-assisted withdrawal of fluid from a site or expelling fluid from the cartridge or syringe barrel having: a plunger rod body with a distal and a proximal end: an end disc at the distal end; a threaded member integral with the end disc designed to engage a plunger; a thumb rest at the proximal end; four longitudinal radially extending rectangular vanes connected to the end disc at the distal end, and to the thumb rest at the proximal end; two pairs of longitudinal radially extending reinforcing vanes forming two triangular configurations with one of the longitudinal radially extending rectangular vanes on one side of the plunger rod body; and two pairs of longitudinal radially extending reinforcing vanes forming two triangular configurations with another of the longitudinal radially extending rectangular vanes on the opposite side of the plunger rod body, each of the pairs of the reinforcing vanes