Abstract: An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.
Type:
Grant
Filed:
September 16, 1996
Date of Patent:
November 9, 1999
Assignee:
Incyte Pharmaceuticals, Inc.
Inventors:
Ronald C. Gamble, Thomas P. Theriault, John D. Baldeschwieler