Patents Represented by Attorney Incyte Pharmaceuticals

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  • CAF1-related protein
    Patent number: 6013450
    Abstract: The invention provides a human CAF1-related protein (CAFRP) and polynucleotides which identify and encode CAFRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CAFRP.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: January 11, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Neil C. Corley, Henry Yue
  • Pancreas-derived serpin
    Patent number: 6013448
    Abstract: The present invention provides nucleotide and amino acid sequences that identify and encode a novel pancreas-derived serpin (PDS) expressed in human pancreas. The present invention also provides for antisense molecules to the nucleotide sequences which encode PDS, expression vectors for the production of purified PDS, antibodies capable of binding specifically to PDS, hybridization probes or oligonucleotides for the detection of PDS-encoding nucleotide sequences, genetically engineered host cells for the expression of PDS, diagnostic tests based on PDS-encoding nucleic acid molecules and a pharmaceutical composition containing PDS capable of binding specifically to a serine protease.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: January 11, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Scott Michael Braxton, Craig G. Wilde, Dinh Diep
  • Kinesin-like motor protein
    Patent number: 6013454
    Abstract: The invention provides a human kinesin-like motor protein (KLIMP) and polynucleotides which identify and encode KLIMP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KLIMP.
    Type: Grant
    Filed: September 28, 1998
    Date of Patent: January 11, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Y. Tom Tang, Neil C. Corley, Karl J. Guegler, Chandra Patterson
  • Protein kinase homologs
    Patent number: 6013455
    Abstract: The invention provides human protein kinase homologs (PKH) and polynucleotides which identify and encode PKH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PKH.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: January 11, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Y. Tom Yang, Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley, Gina A. Gorgone, Yalda Azimzai, Dyung Aina M. Lu
  • Human proton atpase subunit
    Patent number: 6010852
    Abstract: The present invention provides a human proton ATPase subunit (HPAS) and polynucleotides which encode HPAS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HPAS.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: January 4, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Surya K. Goli
  • RAB protein
    Patent number: 6010859
    Abstract: The present invention provides a human novel RAB protein (SRAB) and polynucleotides which identify and encode SRAB. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of SRAB.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: January 4, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Karl J. Guegler
  • Polynucleotides encoding human mitochondrial chaperone proteins
    Patent number: 6010879
    Abstract: The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: January 4, 2000
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Surya K. Goli
  • Cell cycle related proteins
    Patent number: 6008337
    Abstract: The invention provides human cell cycle related proteins (CCRP) and polynucleotides which identify and encode CCRP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of CCRP.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: December 28, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Jennifer L. Hillman, Neil C. Corley, Karl J. Guegler, Henry Yue, Preeti Lal
  • Human preprotachykinin B
    Patent number: 6008194
    Abstract: The invention provides a human preprotachykinin B (PPT-B) and polynucleotides which identify and encode PPT-B. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PPT-B.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: December 28, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Preeti Lal, Matthew R. Kaser
  • Human cysteine protease
    Patent number: 6007997
    Abstract: The present invention provides a polynucleotide (ncp) which identifies and encodes a novel cysteine protease (NCP) expressed in cells of both the adrenal gland and human umbilical vein endothelium. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified NCP peptide, antibodies capable of binding to NCP, inhibitors which bind to NCP and pharmaceutical compositions based on NCP specific antibodies or inhibitors. The invention specifically provides for diagnostic assays based on altered ncp expression and which allow identification of such a condition. These assays utilize probes designed from ncp encoding or controlling nucleic acid sequences or antibodies specific for the NCP.
    Type: Grant
    Filed: November 17, 1998
    Date of Patent: December 28, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Dinh Diep, Scott Michael Braxton, Angelo M. Delegeane
  • Human lysophospholipase
    Patent number: 6004792
    Abstract: The invention provides a new human lysophospholipase (IHLP) and polynucleotides which identify and encode IHLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating inflammation and disorders associated with expression of IHLP.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: December 21, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Purvi Shah, Neil C. Corley, Lynn E. Murry
  • Human S1-5 ECMP-like protein
    Patent number: 6004753
    Abstract: The invention provides a human S1-5 ECMP-like protein (SELP) and polynucleotides which identify and encode SELP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of SELP.
    Type: Grant
    Filed: December 1, 1997
    Date of Patent: December 21, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Henry Yue, Karl J. Guegler, Purvi Shah
  • Embryogenesis protein
    Patent number: 6004778
    Abstract: The invention provides a human embryogenesis protein (EMPRO) and polynucleotides which identify and encode EMPRO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of EMPRO.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: December 21, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Olga Bandman, Preeti Lal, Neil C. Corley
  • Two new human DnaJ-like proteins
    Patent number: 6001598
    Abstract: The invention provides a two new human DnaJ-like proteins (HSPJ1 or HSPJ2) and polynucleotides which identify and encode HSPJ1 or HSPJ2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSPJ1 or HSPJ2.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Janice Au-Young, Preeti Lal, Olga Bandman
  • Mitochondrial adenylate kinase
    Patent number: 6001624
    Abstract: The present invention provides a human mitochondrial adenylate kinase (HMAK) and polynucleotides which encode HMAK. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HMAK.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Purvi Shah
  • Human testin
    Patent number: 6001594
    Abstract: The invention provides a human testin (HTES) and polynucleotides which identify and encode HTES. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HTES.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Preeti Lal, Karl J. Guegler, Neil C. Corley
  • Growth-associated protease inhibitor heavy chain precursor
    Patent number: 6001596
    Abstract: The invention provides a human growth-associated protease inhibitor heavy chain precursor (GAPIP) and polynucleotides which identify and encode GAPIP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of GAPIP.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Karl J. Guegler, Chandra Patterson
  • Human growth-associated methyltransfeases
    Patent number: 6001607
    Abstract: The invention provides a human growth-associated methyltransferase (GAMT) and polynucleotides which identify and encode GAMT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of GAMT.
    Type: Grant
    Filed: April 13, 1998
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Y. Tom Tang, Henry Yue, Karl J. Guegler, Purvi Shah
  • Human lysophosphatidic acid acyltransferase
    Patent number: 6001620
    Abstract: The invention provides a human lysophosphatidic acid acyltranferase (HLPAAT) and polynucleotides which identify and encode HLPAAT. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HLPAAT.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Jennifer L. Hillman, Henry Yue, Karl J. Guegler, Neil C. Corley
  • Human protein disulfide isomerase
    Patent number: 6001632
    Abstract: The present invention provides a polynucleotide (pdih) the partial sequence for which was initially isolated from a lung cDNA library and which identifies and encodes a novel human protein disulfide isomerase (PDIH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PDIH. The invention also provides for the use of purified PDIH and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the abnormal expression of PDIH. Additionally, the invention provides for the use of antisense molecules to pdih or inhibitors of PDIH in pharmaceutical compositions for treatment of diseases.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: December 14, 1999
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Scott Michael Braxton, Lynn E. Murry