Patents Represented by Attorney, Agent or Law Firm Ingrid A. Beattie
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Patent number: 6827936Abstract: Vaccine compositions and immunogenic compositions are described which are glucosyltransferase subunit vaccines for dental caries and which contain at least one peptide which corresponds to a sequence of glucosyltransferase containing aspartate 413, an equivalent of aspartate 413, aspartate 451, an equivalent of aspartate 451, aspartate 562, and equivalent of aspartate 562, aspartate 567, an equivalent of aspartate 567, histidine 561, an equivalent of histidine 561, tryptophan 491, an equivalent of tryptophan 491, glutamate 489, an equivalent of glutamate 489, arginine 449, an equivalent of arginine 449, or combinations thereof. These subunit vaccines elicit antibodies which protect an immunized mammal from dental caries. Methods of provoking an immune response to intact glucosyltransferase are also described.Type: GrantFiled: April 12, 1999Date of Patent: December 7, 2004Assignee: Forsyth Dental Infirmary for ChildrenInventors: Daniel J. Smith, Martin A. Taubman
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Patent number: 6815415Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.Type: GrantFiled: July 11, 2001Date of Patent: November 9, 2004Assignee: Rhode Island HospitalInventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
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Patent number: 6812206Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.Type: GrantFiled: July 11, 2001Date of Patent: November 2, 2004Assignee: Rhode Island HospitalInventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
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Patent number: 6812251Abstract: The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death.Type: GrantFiled: March 15, 2002Date of Patent: November 2, 2004Assignee: Rhode Island HospitalInventors: Paul Calabresi, Bai-Chuan Pan, James Darnowski
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Patent number: 6811786Abstract: The invention describes therapeutic compositions including a lactic acid-producing bacteria, such as isolated Bacillus coagulans, in combination with a bifidogenic oligosaccharides or other cholesterol-reducing agents for use in reducing LDL cholesterol and serum triglycerides. Also described are therapeutic methods using the compositions and systems containing the therapeutic compositions.Type: GrantFiled: April 6, 2001Date of Patent: November 2, 2004Assignee: Ganeden Biotech, Inc.Inventors: Sean Farmer, Andrew R. Lefkowitz
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Patent number: 6797696Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.Type: GrantFiled: July 11, 2001Date of Patent: September 28, 2004Assignee: Rhode Island HospitalInventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
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Patent number: 6783758Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.Type: GrantFiled: July 11, 2001Date of Patent: August 31, 2004Assignee: Rhode Island HospitalInventors: Jack R. Wands, Suzanne M. de la Monte, Nedim Ince, Rolf I. Carlson
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Patent number: 6781030Abstract: The present invention pertains to methods for cloning animals. In particular, the invention includes methods of cloning an animal by combining a genome from an activated donor cell with an activated enucleated oocyte to thereby obtain a nuclear transfer embryo, and impregnating an animal with the nuclear transfer embryo in conditions suitable for gestation of a cloned animal. The invention further relates to methods of chemically enucleating an oocyte having a meiotic spindle apparatus by exposing the oocyte with a compound that destabilizes the meiotic spindle apparatus.Type: GrantFiled: November 2, 1999Date of Patent: August 24, 2004Assignee: Trustee of Tufts College, Ballou HallInventors: Alexander Baguisi, Eric W. Overstrom
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Patent number: 6777537Abstract: Novel gene encoding a human 116-kDa osteoclast proton pump subunit and the protein encoded thereby. Methods of treatment of bone mass disorders utilizing said gene, and antibodies that bind to the protein encoded by said gene.Type: GrantFiled: July 18, 2000Date of Patent: August 17, 2004Assignee: Forsyth Dental Infirmary for ChildrenInventors: Philip Stashenko, Yi-Ping Li
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Patent number: 6770797Abstract: The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated neuronal cell death.Type: GrantFiled: June 1, 2001Date of Patent: August 3, 2004Assignee: Rhode Island HospitalInventors: Jack R. Wands, Suzanne M. de la Monte
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Patent number: 6753328Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.Type: GrantFiled: October 1, 2002Date of Patent: June 22, 2004Assignee: Rhode Island HospitalInventors: Jack R. Wands, Rolf I. Carlson, Paul Maggio
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Patent number: 6753457Abstract: The present invention concerns products and methods particularly useful for activating and analyzing non-dividing cell nuclei. The featured products include activating egg extracts, cytostatic factor (CSF) extracts, kits containing these extracts, and a microchamber microscope slide useful in analyzing nucleus activation.Type: GrantFiled: January 6, 1999Date of Patent: June 22, 2004Assignee: TranxenogenInventor: Lawrence J. Wangh
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Patent number: 6750323Abstract: A substantially pure platelet activation polypeptide including a sequence at least 70% identical to SEQ ID NO:1, and a DNA encoding such a polypeptide.Type: GrantFiled: December 12, 2000Date of Patent: June 15, 2004Assignee: President and Fellows of Harvard CollegeInventors: Guy Reed, Christophe Y. Clement
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Patent number: 6743774Abstract: The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.Type: GrantFiled: April 23, 1999Date of Patent: June 1, 2004Assignee: Rhode Island HospitalInventor: Gregory D. Jay
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Patent number: 6720007Abstract: The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness.Type: GrantFiled: October 25, 2001Date of Patent: April 13, 2004Assignee: Tufts UniversityInventors: David R. Walt, Tarun K. Mandal, Michael S. Fleming
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Patent number: 6703413Abstract: The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death by apoptosis.Type: GrantFiled: August 5, 2002Date of Patent: March 9, 2004Assignee: Rhode Island HospitalInventors: Paul Calabresi, James Darnowski
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Patent number: 6686199Abstract: The invention features a method of delivering DNA to a spermatogonium by infusing DNA in situ into a testicle of a non-human animal and administering a condition or substance to the testicle to increase uptake of DNA by the spermatogonium.Type: GrantFiled: February 9, 1999Date of Patent: February 3, 2004Assignee: Tran Xenogen, Inc.Inventors: Paul A. DiTullio, Karl M. Ebert
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Patent number: 6660482Abstract: The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under conditions sufficient to form an ITI-ligand complex and detecting the complex.Type: GrantFiled: February 28, 2000Date of Patent: December 9, 2003Assignee: Rhode Island HospitalInventors: Yow-Pin Lim, Douglas C. Hixson
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Patent number: 6652583Abstract: The invention provides a replacement heart valve which contains an acellular matrix as a structural scaffold. The scaffold is seeded with isolated myofibroblasts and/or endothelial cells prior to implantation into a recipient mammal.Type: GrantFiled: April 9, 2001Date of Patent: November 25, 2003Assignee: Rhode Island HospitalInventors: Richard A. Hopkins, Diane Hoffman-Kim
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Patent number: 6638717Abstract: The present invention relates to a highly efficient, high-throughput method for the identification and elimination of redundancy in a population of nucleic acid molecules using microarrays. This method involves a reiterative subtraction protocol that creates a library that becomes more biased toward unknown genes with each successive round. The removal of repetitive and previously characterized nucleic acids from the library allows the identification of low-abundance mRNA from sources of interest and enhances the rate of novel gene discovery. The present invention is also useful for the removal of contaminating nucleic acids from cloning libraries.Type: GrantFiled: May 19, 1999Date of Patent: October 28, 2003Assignee: Aventis Pharmaceuticals, Inc.Inventors: Steven Perrin, Kathy Call, Timothy Connolly