Patents Represented by Attorney Irene J. Frangos
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Patent number: 5177154Abstract: A water compatible terpolymer for sealing and coating building materials which protects surfaces from environmental staining agents. The terpolymer is created by polymerizing a HEMA:SMA co-polymer with another monomer which contains either free acid or base groups. The resultant terpolymer is water solution after neutralization. Water is then added to bring the solvent level to 40% maximum and the solids level to 8%.Type: GrantFiled: April 30, 1991Date of Patent: January 5, 1993Assignee: National Patent Development Corp.Inventor: Daniel G. Moro
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Patent number: 5055268Abstract: An air-borne chemical sensor system includes a motor and impeller to draw an air sample into a housing containing a sensor which will provide a signal for display related to the amount of a particular air-borne chemical in a given air sample. The system is controllable by different duration activation of a single activating switch which can further control a secondary function, such as a flashlight.Type: GrantFiled: August 8, 1990Date of Patent: October 8, 1991Assignee: Easterm Electronics Manufacturing Corp.Inventor: Peter G. Martin
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Patent number: 5049380Abstract: The present invention describes a novel material which is extractable from plants of the order Malvales and which demonstrates anti-allergic activity.Type: GrantFiled: May 2, 1989Date of Patent: September 17, 1991Assignee: Bar-Ilan UniversityInventors: Shlomo Grossman, Rina Reznik, David Altman
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Patent number: 5045266Abstract: An acoustically sealed earmold for a hearing aid insertable into the ear of individuals with impaired hearing can be prepared in situ employing the hydrophilic composite polymer materials described herein. Such composite materials include at least one hydrophilic polymer in a powder form and one or more liquid components of which at least one is hydrophilic and which can be polymerized with said hydrophilic polymer. The resulting earmold has a shape-retaining, non-tacky flexible consistency which allows it to be shaped further and also to be modified to accommodate a receiver adapter or external receiver. The earmold can then be cured by any of the conventional curing methods to retain its shape permanently. This method enables an audiologist to fit the earmold and evaluate the hearing aid in a single office visit.Type: GrantFiled: November 2, 1989Date of Patent: September 3, 1991Assignee: National Patent Development CorporationInventors: Daniel G. Moro, Samuel H. Ronel, Petr Kuzma
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Patent number: 5039342Abstract: Chemical modified asphalt cements are produced by reacting bituminous materials with ethylenically unsaturated monomers.Type: GrantFiled: May 8, 1990Date of Patent: August 13, 1991Assignees: Herman Mark, National Patent Development CorporationInventor: Murray Jelling
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Patent number: 4977087Abstract: A method for regenerating plantlets from protoplasts isolated from mesophyll cells of abacterial seedlings of red bean (Phaseolus angularis). Protoplasts cultured in certain liquid media could divide continuously and many protoplast-derived calli may be obtained. In addition, various growth media containing the optimum concentration and the type of sugar, mineral salts, vitamins, and combinations and concentrations of several phytohormones for protoplast growth, division, callus formation and plantlet regeneration are provided.Type: GrantFiled: January 19, 1988Date of Patent: December 11, 1990Assignee: Interferon Sciences, Inc.Inventors: Ge Koulin, Wang Yunzhu, Yuan Xunmei, Huang Peiming
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Patent number: 4957436Abstract: A fluid dispensing system comprising a flexible container for simultaneously dispensing two fluids, and dispensing apparatus for controlled compression of the container. The flexible container includes two separate and independent compartments, each compartment comprising a reservoir portion for holding a supply of one of said two fluids, an outlet and a bi-ended labyrinthine portion communicating with the reservoir portion at one end thereof and with the outlet at the other end thereof. The dispensing apparatus includes a frame having a fixed wall and a movable container impinging member for movement relative to the fixed wall for squeezing the container therebetween to effect the dispensing of the two fluids therefrom substantially simultaneously.Type: GrantFiled: March 28, 1986Date of Patent: September 18, 1990Assignee: National Patent Development CorporationInventor: Francis E. Ryder
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Patent number: 4956999Abstract: A method and apparatus for monitoring the structural acoustic signature of a structural member in response to a transient load, corresponding to detected vibration frequencies transmitted by the structural member including the fundamental and harmonic frequencies of the structural member, to determine changes in structural integrity and to determine the nature and type of transient loads. The structural acoustic signature of the structural member in a first condition in response to a first transient load is compared to a structural acoustic signature from a second transient load whereby differences in the signatures correspond to the occurrence of changes in the elastic qualities or condition of the structural member. The signatures are preferably evaluated in the frequency domain. The nature and type of transient load can be determined by evaluating the waveform shape of a structural member in response to the unknown load against a history of waveform shapes corresponding to known loads.Type: GrantFiled: October 27, 1989Date of Patent: September 18, 1990Assignee: GP Taurio, Inc.Inventors: William L. Bohannan, Harrington, J. Vincent, John K. Pfister
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Patent number: 4911908Abstract: An interferon preparation to be administered topically is provided comprising: (a) a therapeutically effective amount of one or more interferons; (b) a vehicle base compatible with the interferon or interferons being administered; (c) an effective amount of one or more protease inhibitors for the purpose of reducing the rate of decay of the biological activity of the interferon or interferons due to proteolytic agents; and (d) an effective amount of one or more anti-microbial agents. In certain preferred embodiments of the invention, the vehicle base is prepared from a mixture of polyethylene glycols or includes hydroxyethyl cellulose as a thickening agent.Type: GrantFiled: March 12, 1987Date of Patent: March 27, 1990Assignee: Interferon Sciences, Inc.Inventors: Leonard F. Estis, Sean A. Evans, Douglas Testa
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Patent number: 4901575Abstract: A method and apparatus for monitoring the structural acoustic signature of a structural member in response to a transient load, corresponding to detected vibration frequencies transmitted by the structural member including the fundamental and harmonic frequencies of the structural member, to determine changes in structural integrity and to determine the nature and type of transient loads. The structural acoustic signature of the structural member in a first condition in response to a first transient load is compared to a structural acoustic signature from a second transient load whereby differences in the signatures correspond to the occurrence of changes in the elastic qualities or condition of the structural member. The signatures are preferably evaluated in the frequency domain. The nature and type of transient load can be determined by evaluating the waveform shape of a structural member in response to the unknown load against a history of waveform shapes corresponding to known laods.Type: GrantFiled: November 30, 1988Date of Patent: February 20, 1990Assignee: GP Taurio, Inc.Inventors: William L. Bohannan, J. Vincent Harrington, John K. Pfister
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Patent number: 4902426Abstract: The present invention comprises a process for separating rare earth ions or actinide ions or mixtures thereof in solution by passing the solution through an ion exchange material to separate the rare earths or actinides or mixtures thereof. The ion exchange material has a surface area of about 5-1500 m.sup.2 /g. The ion exchange material is impregnated with a liquid containing alkali metal cations, Group Ib metal cations, ammonium cations, organic amines or mixtures thereof, at a pH range above about 9. A plurality of fractions of the solution is collected as the solution passes through the ion exchange material, preferably in a column. This process is particularly preferred for separating rare earth ions and especially lanthanum and neodymium. It is particularly preferred to purify lanthanum to contain less than 0.1 ppm, preferably less than 0.01 ppm, of neodymium.Type: GrantFiled: May 20, 1988Date of Patent: February 20, 1990Assignees: Pedro B. Macedo, Theodore Aaron LitovitzInventors: Pedro B. Macedo, Theodore A. Litovitz, Hamid Hojaj
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Patent number: 4814170Abstract: This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies formed to said immunogen.Type: GrantFiled: March 14, 1986Date of Patent: March 21, 1989Assignee: Aphton CorporationInventor: Stephen L. Karr, Jr.
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Patent number: 4795634Abstract: This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies, which anti-idiotypic antibodies express internal images of zona pellucida antigenic determinants capable of eliciting a contraceptive response.Type: GrantFiled: March 14, 1986Date of Patent: January 3, 1989Assignee: Aphton CorporationInventors: Stephen Grimes, Elizer Benjamini, Philip Gevas
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Patent number: 4788143Abstract: A patient's level of cell-mediated immunity is determined by obtaining a blood sample from the patient, incubating cells from the sample in a tissue culture medium containing Concanavalin A, and observing the number of polykaryons produced or the number of nuclei per polykaryon or both to thereby determine the level of cell-mediated immunity of the hose from which the blood sample was obtained.Type: GrantFiled: April 30, 1984Date of Patent: November 29, 1988Inventors: Alexander A. Yabrov, Theodore Khavkin
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Patent number: 4770632Abstract: The present invention relates to an improved delivery system for a dental treatment solution. More particularly, the apparatus disclosed includes a housing defining a well, a reservoir container for the dental treatment solution, and a pump for delivery of the solution to a hand piece. The pump includes an electrically energizable prime mover such as a motor or solenoid, a heater, and a control for the overall system. The control for the system provides a timing arrangement which is actuated upon placement of the reservoir container within the housing well, and which disables the system upon completion of the timing cycle. This feature, coupled with the employment of a visual signal, provides a dental professional with an indication of the strength or useful life of the dental treatment solution. Also disclosed are novel constructions for the pump and the heater, along with a novel design for the reservoir container.Type: GrantFiled: December 30, 1985Date of Patent: September 13, 1988Assignee: National Patent Development CorporationInventors: Francis E. Ryder, Stephen P. Lisak
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Patent number: 4765903Abstract: Fast moving monomers of alpha-2 interferon ("IFN-alpha-2") are purified from slow moving monomers and oligomers of interferon and from noninterferon proteins using a combination of immunoaffinity chromatography, reverse phase HPLC, cation exchange chromatography, and gel filtration. Two fast monomer forms, FMM.sub.1 and FMM.sub.2, are further distinguished on the basis of charge and hydrophobicity and FMM.sub.2 is obtained in essentially homogeneous form with respect to size, hydrophobicity and charge.Type: GrantFiled: October 6, 1987Date of Patent: August 23, 1988Assignee: Interferon Sciences, Inc.Inventors: Mark J. D'Andrea, Stanley J. Tarnowski, Jr., Arthur D. Clark, Jr.
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Patent number: 4744907Abstract: Hydroxyalkyl celluloses are useful as sedimenting agents in the non-destructive separation of red and white blood cells. Intact WBC recovery is higher than with conventional methods. The white blood cells may be used in interferon production.Type: GrantFiled: January 16, 1987Date of Patent: May 17, 1988Assignee: Interferon Sciences, Inc.Inventor: Robert J. Klimchak
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Patent number: 4738530Abstract: An inspection device for visually ascertaining the desired alignment of a contact lens in a tinting fixture comprises a base and a platform having a flat surface and mounted to the base for rotation relative thereto. The device also includes an arrangement for mounting the fixture for rotation in unison with the platform and for aligning the fixture relative to the platform flat surface in such a way as to maintain the contact lens in an alignment wherein substantially the entire peripheral edge thereof is located in a plane substantially parallel to the platform flat surface, if the contact lens is in the proper desired alignment in the tinting fixture, and such that the tinting fixture is centered relative to the center of rotation of the platform.Type: GrantFiled: July 10, 1986Date of Patent: April 19, 1988Assignee: National Patent Development CorporationInventors: Francis E. Ryder, Richard Rabenau, Rowland W. Kanner
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Patent number: 4661524Abstract: Pharmaceutical compositions with comprise a compound of the formula (I): ##STR1## wherein X is a chlorine or bromine atom or a methoxyl, methylthio or alkyl group of 1-4 carbon atoms; Y is a --CHR.sub.1 --CH.sub.2 -- or --CR.sub.1 .dbd.CH-- group where R.sub.1 is a hydrogen atom or a methyl group and A is a CHOH or CO group, and a pharmaceutically acceptable carrier selected from the group of creams, ointments, lotions, gels, aerosols, sprays, liniments and gel sticks. The compositions possess systemic anti-inflammatory activity when administered topically.Type: GrantFiled: December 27, 1985Date of Patent: April 28, 1987Assignee: Beecham Group P.L.C.Inventors: Michael J. Thomson, Frank R. Mangan
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Patent number: 4638066Abstract: Compounds of formula (I), ##STR1## or an N-oxide or pharmaceutically acceptable salt thereof, wherein R.sub.1 is hydrogen, C.sub.1-7 alkyl, C.sub.3-7 cycloalkyl, C.sub.4-7 cycloalkenyl or C.sub.1-4 alkyl substituted by C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, C.sub.3-7 cycloalkyl, hydroxy, thiol, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, carboxy, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkanoyl, amino optionally substituted by one or two C.sub.1-4 alkyl or by C.sub.4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C.sub.1-4 alkyl, or benzoyl or phenyl either being optionally ring-substituted by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or trifluoromethyl, R.sub.2 and R.sub.3 are the same or different and are hydrogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, halogen or trifluoromethyl, m is 1 to 3 and n is 1 or 2, the hydrogen atom bonded to the C.sub.a carbon atom being trans to the hydrogen atom bonded to the C.sub.Type: GrantFiled: December 20, 1984Date of Patent: January 20, 1987Assignee: Beecham Group p.l.c.Inventors: Laramie M. Gaster, Barry S. Orlek