Patents Represented by Attorney Irene J. Frangos
  • Patent number: 5177154
    Abstract: A water compatible terpolymer for sealing and coating building materials which protects surfaces from environmental staining agents. The terpolymer is created by polymerizing a HEMA:SMA co-polymer with another monomer which contains either free acid or base groups. The resultant terpolymer is water solution after neutralization. Water is then added to bring the solvent level to 40% maximum and the solids level to 8%.
    Type: Grant
    Filed: April 30, 1991
    Date of Patent: January 5, 1993
    Assignee: National Patent Development Corp.
    Inventor: Daniel G. Moro
  • Patent number: 5055268
    Abstract: An air-borne chemical sensor system includes a motor and impeller to draw an air sample into a housing containing a sensor which will provide a signal for display related to the amount of a particular air-borne chemical in a given air sample. The system is controllable by different duration activation of a single activating switch which can further control a secondary function, such as a flashlight.
    Type: Grant
    Filed: August 8, 1990
    Date of Patent: October 8, 1991
    Assignee: Easterm Electronics Manufacturing Corp.
    Inventor: Peter G. Martin
  • Patent number: 5049380
    Abstract: The present invention describes a novel material which is extractable from plants of the order Malvales and which demonstrates anti-allergic activity.
    Type: Grant
    Filed: May 2, 1989
    Date of Patent: September 17, 1991
    Assignee: Bar-Ilan University
    Inventors: Shlomo Grossman, Rina Reznik, David Altman
  • Patent number: 5045266
    Abstract: An acoustically sealed earmold for a hearing aid insertable into the ear of individuals with impaired hearing can be prepared in situ employing the hydrophilic composite polymer materials described herein. Such composite materials include at least one hydrophilic polymer in a powder form and one or more liquid components of which at least one is hydrophilic and which can be polymerized with said hydrophilic polymer. The resulting earmold has a shape-retaining, non-tacky flexible consistency which allows it to be shaped further and also to be modified to accommodate a receiver adapter or external receiver. The earmold can then be cured by any of the conventional curing methods to retain its shape permanently. This method enables an audiologist to fit the earmold and evaluate the hearing aid in a single office visit.
    Type: Grant
    Filed: November 2, 1989
    Date of Patent: September 3, 1991
    Assignee: National Patent Development Corporation
    Inventors: Daniel G. Moro, Samuel H. Ronel, Petr Kuzma
  • Patent number: 5039342
    Abstract: Chemical modified asphalt cements are produced by reacting bituminous materials with ethylenically unsaturated monomers.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: August 13, 1991
    Assignees: Herman Mark, National Patent Development Corporation
    Inventor: Murray Jelling
  • Patent number: 4977087
    Abstract: A method for regenerating plantlets from protoplasts isolated from mesophyll cells of abacterial seedlings of red bean (Phaseolus angularis). Protoplasts cultured in certain liquid media could divide continuously and many protoplast-derived calli may be obtained. In addition, various growth media containing the optimum concentration and the type of sugar, mineral salts, vitamins, and combinations and concentrations of several phytohormones for protoplast growth, division, callus formation and plantlet regeneration are provided.
    Type: Grant
    Filed: January 19, 1988
    Date of Patent: December 11, 1990
    Assignee: Interferon Sciences, Inc.
    Inventors: Ge Koulin, Wang Yunzhu, Yuan Xunmei, Huang Peiming
  • Patent number: 4956999
    Abstract: A method and apparatus for monitoring the structural acoustic signature of a structural member in response to a transient load, corresponding to detected vibration frequencies transmitted by the structural member including the fundamental and harmonic frequencies of the structural member, to determine changes in structural integrity and to determine the nature and type of transient loads. The structural acoustic signature of the structural member in a first condition in response to a first transient load is compared to a structural acoustic signature from a second transient load whereby differences in the signatures correspond to the occurrence of changes in the elastic qualities or condition of the structural member. The signatures are preferably evaluated in the frequency domain. The nature and type of transient load can be determined by evaluating the waveform shape of a structural member in response to the unknown load against a history of waveform shapes corresponding to known loads.
    Type: Grant
    Filed: October 27, 1989
    Date of Patent: September 18, 1990
    Assignee: GP Taurio, Inc.
    Inventors: William L. Bohannan, Harrington, J. Vincent, John K. Pfister
  • Patent number: 4957436
    Abstract: A fluid dispensing system comprising a flexible container for simultaneously dispensing two fluids, and dispensing apparatus for controlled compression of the container. The flexible container includes two separate and independent compartments, each compartment comprising a reservoir portion for holding a supply of one of said two fluids, an outlet and a bi-ended labyrinthine portion communicating with the reservoir portion at one end thereof and with the outlet at the other end thereof. The dispensing apparatus includes a frame having a fixed wall and a movable container impinging member for movement relative to the fixed wall for squeezing the container therebetween to effect the dispensing of the two fluids therefrom substantially simultaneously.
    Type: Grant
    Filed: March 28, 1986
    Date of Patent: September 18, 1990
    Assignee: National Patent Development Corporation
    Inventor: Francis E. Ryder
  • Patent number: 4911908
    Abstract: An interferon preparation to be administered topically is provided comprising: (a) a therapeutically effective amount of one or more interferons; (b) a vehicle base compatible with the interferon or interferons being administered; (c) an effective amount of one or more protease inhibitors for the purpose of reducing the rate of decay of the biological activity of the interferon or interferons due to proteolytic agents; and (d) an effective amount of one or more anti-microbial agents. In certain preferred embodiments of the invention, the vehicle base is prepared from a mixture of polyethylene glycols or includes hydroxyethyl cellulose as a thickening agent.
    Type: Grant
    Filed: March 12, 1987
    Date of Patent: March 27, 1990
    Assignee: Interferon Sciences, Inc.
    Inventors: Leonard F. Estis, Sean A. Evans, Douglas Testa
  • Patent number: 4901575
    Abstract: A method and apparatus for monitoring the structural acoustic signature of a structural member in response to a transient load, corresponding to detected vibration frequencies transmitted by the structural member including the fundamental and harmonic frequencies of the structural member, to determine changes in structural integrity and to determine the nature and type of transient loads. The structural acoustic signature of the structural member in a first condition in response to a first transient load is compared to a structural acoustic signature from a second transient load whereby differences in the signatures correspond to the occurrence of changes in the elastic qualities or condition of the structural member. The signatures are preferably evaluated in the frequency domain. The nature and type of transient load can be determined by evaluating the waveform shape of a structural member in response to the unknown load against a history of waveform shapes corresponding to known laods.
    Type: Grant
    Filed: November 30, 1988
    Date of Patent: February 20, 1990
    Assignee: GP Taurio, Inc.
    Inventors: William L. Bohannan, J. Vincent Harrington, John K. Pfister
  • Patent number: 4902426
    Abstract: The present invention comprises a process for separating rare earth ions or actinide ions or mixtures thereof in solution by passing the solution through an ion exchange material to separate the rare earths or actinides or mixtures thereof. The ion exchange material has a surface area of about 5-1500 m.sup.2 /g. The ion exchange material is impregnated with a liquid containing alkali metal cations, Group Ib metal cations, ammonium cations, organic amines or mixtures thereof, at a pH range above about 9. A plurality of fractions of the solution is collected as the solution passes through the ion exchange material, preferably in a column. This process is particularly preferred for separating rare earth ions and especially lanthanum and neodymium. It is particularly preferred to purify lanthanum to contain less than 0.1 ppm, preferably less than 0.01 ppm, of neodymium.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: February 20, 1990
    Assignees: Pedro B. Macedo, Theodore Aaron Litovitz
    Inventors: Pedro B. Macedo, Theodore A. Litovitz, Hamid Hojaj
  • Patent number: 4814170
    Abstract: This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies formed to said immunogen.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: March 21, 1989
    Assignee: Aphton Corporation
    Inventor: Stephen L. Karr, Jr.
  • Patent number: 4795634
    Abstract: This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies, which anti-idiotypic antibodies express internal images of zona pellucida antigenic determinants capable of eliciting a contraceptive response.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: January 3, 1989
    Assignee: Aphton Corporation
    Inventors: Stephen Grimes, Elizer Benjamini, Philip Gevas
  • Patent number: 4788143
    Abstract: A patient's level of cell-mediated immunity is determined by obtaining a blood sample from the patient, incubating cells from the sample in a tissue culture medium containing Concanavalin A, and observing the number of polykaryons produced or the number of nuclei per polykaryon or both to thereby determine the level of cell-mediated immunity of the hose from which the blood sample was obtained.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: November 29, 1988
    Inventors: Alexander A. Yabrov, Theodore Khavkin
  • Patent number: 4770632
    Abstract: The present invention relates to an improved delivery system for a dental treatment solution. More particularly, the apparatus disclosed includes a housing defining a well, a reservoir container for the dental treatment solution, and a pump for delivery of the solution to a hand piece. The pump includes an electrically energizable prime mover such as a motor or solenoid, a heater, and a control for the overall system. The control for the system provides a timing arrangement which is actuated upon placement of the reservoir container within the housing well, and which disables the system upon completion of the timing cycle. This feature, coupled with the employment of a visual signal, provides a dental professional with an indication of the strength or useful life of the dental treatment solution. Also disclosed are novel constructions for the pump and the heater, along with a novel design for the reservoir container.
    Type: Grant
    Filed: December 30, 1985
    Date of Patent: September 13, 1988
    Assignee: National Patent Development Corporation
    Inventors: Francis E. Ryder, Stephen P. Lisak
  • Patent number: 4765903
    Abstract: Fast moving monomers of alpha-2 interferon ("IFN-alpha-2") are purified from slow moving monomers and oligomers of interferon and from noninterferon proteins using a combination of immunoaffinity chromatography, reverse phase HPLC, cation exchange chromatography, and gel filtration. Two fast monomer forms, FMM.sub.1 and FMM.sub.2, are further distinguished on the basis of charge and hydrophobicity and FMM.sub.2 is obtained in essentially homogeneous form with respect to size, hydrophobicity and charge.
    Type: Grant
    Filed: October 6, 1987
    Date of Patent: August 23, 1988
    Assignee: Interferon Sciences, Inc.
    Inventors: Mark J. D'Andrea, Stanley J. Tarnowski, Jr., Arthur D. Clark, Jr.
  • Patent number: 4744907
    Abstract: Hydroxyalkyl celluloses are useful as sedimenting agents in the non-destructive separation of red and white blood cells. Intact WBC recovery is higher than with conventional methods. The white blood cells may be used in interferon production.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: May 17, 1988
    Assignee: Interferon Sciences, Inc.
    Inventor: Robert J. Klimchak
  • Patent number: 4738530
    Abstract: An inspection device for visually ascertaining the desired alignment of a contact lens in a tinting fixture comprises a base and a platform having a flat surface and mounted to the base for rotation relative thereto. The device also includes an arrangement for mounting the fixture for rotation in unison with the platform and for aligning the fixture relative to the platform flat surface in such a way as to maintain the contact lens in an alignment wherein substantially the entire peripheral edge thereof is located in a plane substantially parallel to the platform flat surface, if the contact lens is in the proper desired alignment in the tinting fixture, and such that the tinting fixture is centered relative to the center of rotation of the platform.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: April 19, 1988
    Assignee: National Patent Development Corporation
    Inventors: Francis E. Ryder, Richard Rabenau, Rowland W. Kanner
  • Patent number: 4661524
    Abstract: Pharmaceutical compositions with comprise a compound of the formula (I): ##STR1## wherein X is a chlorine or bromine atom or a methoxyl, methylthio or alkyl group of 1-4 carbon atoms; Y is a --CHR.sub.1 --CH.sub.2 -- or --CR.sub.1 .dbd.CH-- group where R.sub.1 is a hydrogen atom or a methyl group and A is a CHOH or CO group, and a pharmaceutically acceptable carrier selected from the group of creams, ointments, lotions, gels, aerosols, sprays, liniments and gel sticks. The compositions possess systemic anti-inflammatory activity when administered topically.
    Type: Grant
    Filed: December 27, 1985
    Date of Patent: April 28, 1987
    Assignee: Beecham Group P.L.C.
    Inventors: Michael J. Thomson, Frank R. Mangan
  • Patent number: 4638066
    Abstract: Compounds of formula (I), ##STR1## or an N-oxide or pharmaceutically acceptable salt thereof, wherein R.sub.1 is hydrogen, C.sub.1-7 alkyl, C.sub.3-7 cycloalkyl, C.sub.4-7 cycloalkenyl or C.sub.1-4 alkyl substituted by C.sub.2-7 alkenyl, C.sub.2-7 alkynyl, C.sub.3-7 cycloalkyl, hydroxy, thiol, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, carboxy, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkanoyl, amino optionally substituted by one or two C.sub.1-4 alkyl or by C.sub.4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C.sub.1-4 alkyl, or benzoyl or phenyl either being optionally ring-substituted by C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or trifluoromethyl, R.sub.2 and R.sub.3 are the same or different and are hydrogen, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, halogen or trifluoromethyl, m is 1 to 3 and n is 1 or 2, the hydrogen atom bonded to the C.sub.a carbon atom being trans to the hydrogen atom bonded to the C.sub.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: January 20, 1987
    Assignee: Beecham Group p.l.c.
    Inventors: Laramie M. Gaster, Barry S. Orlek