Abstract: There is provided a device for the administration of an inhalation medicament, including a body defining a through-going air pathway having a longitudinal axis, an air inlet, an air outlet forming a mouthpiece, means for dispensing medicament into the pathway and air flow regulating means, characterized in that the air flow regulating means includes a movable obstructing means adapted to reduce the cross-sectional area of the pathway at a location between the air inlet and the means for dispensing medicament, and biassing means, whereby the obstructing means is biassed into a first resting position in which the cross-sectional area of the pathway is minimum and is adapted to move against the bias of the biassing means to a second position in which the cross-section area of the pathway is maximum in response to a pressure fall at the mouthpiece caused by inhalation and is adapted to move farther to a third position in which the cross-sectional area of the pathway is less than maximum in response to a greater p

Abstract: This invention is directed to the pharmaceutical use of phenyl compounds, which are linked to an aryl moiety by various linkages, for inhibiting tumor necrosis factor. The invention is also directed to the compounds, their preparation and pharmaceutical compositions containing these compounds. Furthermore, this invention is directed to the pharmaceutical use of the compounds for inhibiting cyclic AMP phosphodiesterase.

Abstract: An inhaler for inhaling pulverulent medicament from within a capsule comprises a chamber 24 within which the capsule is free to rotate while having its longitudinal axis in the median plane of the chamber and thus generally parallel to the front and rear walls 30 and 31 of the chamber, by virtue of the fact that the spacing between said front and rear walls is less than the axial length of the capsule but just greater than the diameter of the capsule. The device includes pins 21 serving as opening means to pierce the ends of the capsule while it is seated in a recess 25, whereupon the retraction of the pins 21 allows the capsule to be entrained into swirling airflow in the chamber 24 during inhalation of air through air inlets 26 and out through a mouthpiece nozzle 27.

Abstract: Reduction (preferably elimination) of the HSP150 protein in a yeast used to produce desired foreign proteins, especially human albumin, facilitates purification of the protein.

Abstract: Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.

Abstract: A method of linking nucleosides with a siloxane bridge comprising reacting a 3'-silylated-5'-protected nucleoside with an unprotected nucleoside is disclosed. The silylated and unprotected nucleosides may be either monomeric nucleosides or the terminal nucleosides of an oligonucleotide or oligonucleotide analog. A method of synthesizing an oligonucleotide analog having siloxane internucleoside linkages is also disclosed. The method of synthesis comprises silylating a 5'-protected nucleoside with a bifunctional silylating reagent to form a 3'-silylated nucleoside, reacting the silylated nucleoside with an unprotected nucleoside in the presence of a base catalyst and repeating these steps to form an oligonucleotide analog. A modified solid phase synthesis method for preparing an oligonucleotide analog having siloxane internucleoside linkages is also disclosed.

Abstract: Particles having an average diameter of less than about 12 microns comprising fatty acid cores encapsulated with human serum albumin and methods for their preparation are disclosed. These materials are useful as contrast agents in ultrasonic imaging, having scattering intensities that are equivalent to or greater than those obtain from dispersed microbubbles but being much more stable, both in storage and when used in vivo, than are contrast agents based on dispersed microbubbles.

Abstract: Preformed, water-soluble, acrylamide based copolymers comprising a minor proportion of a comonomer, which comonomer contains a site for a crosslinking reaction with a selected crosslinking agent by a reaction that does not involve a free-radical vinyl addition mechanism, which copolymers have M.sub.w and M.sub.n values within selected ranges, can be conveniently and safely used to prepare electrophoresis gel media in situ.

Abstract: A unique combination of isopropyl and isobutyl alcohols synergistically increases the permeability of the skin to steroid drugs.

Abstract: A merocyanine dye having the formula: ##STR1## wherein: R.sub.1 and R.sub.2 independently are H, alkyl, alkoxy or aryl; R.sub.7 and R.sub.8 are H orany of R.sub.1 and R.sub.2, R.sub.1 and R.sub.7, and R.sub.2 and R.sub.8 can together comprise the atoms necessary to form a fused aromatic ring on the benzene radical to which they are attached and with the stipulation that only one of R.sub.1 and R.sub.2 can be H;R.sub.5 and R.sub.6 comprise alkyl of from 1-18 carbon atoms, provided that the sum of the carbon atoms in R.sub.5 and R.sub.6 together is at least 8;R.sub.9 is an alkylene group of 2-9 nuclear carbon and hetero atoms; andZ.sup.+ is a cation.This dye is useful in a method for inactivating viruses comprising contacting the viruses with the compound and exposing the resulting mixture to visible light to excite and inactivate the viruses. The compounds are also useful in the irradiation-induced inactivation of leukemia cells.

Abstract: Administration of chroman, 6-hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid, prior to or simultaneously with resuming normal blood supply to the heart following ischemia provides substantial protection from tissue damage that otherwise is observed upon reperfusion of the heart.

Abstract: Means for absorbing sebum screted by sebacious glands of a subject as well as providing semi-quantitative estimation of the rate of sebum production at various sites on the subject's skin and a record of excretion patterns on the skin, said means comprising a microporous hydrophobic polymeric film substrate coated on a major surface with a high molecular weight adhesive that is resistant to migration into the pores of the polymeric film. Said means may also be used to provide therapy by absorbing excess sebum or delivering medication to sites or abnormal sebum secretion. Method for ascertaining secretion patterns on the skin by applying to the skin for a preselected time a microporous, hydrophobic, polymeric film.

Abstract: Pressure-sensitive adhesive compositions having decreased resistance to peel removal while maintaining high shear resistance, i.e., holding-power adhesion, in air and in water comprising an elastomeric blend of a selected rubber and a selected olefin terpolymer having a Modulus, M.sub.60, at 60% elongation of from about 1 to about 1.5 and a polydisparity of no more than about 10, a liquid plasticizer, a reinforcing filler and a solid tackifier.

Abstract: Treatment of inflammation by applying topically a selected acylaminophenol in a pharmaceutically acceptable topical vehicle.

Abstract: Periodic administration of N-(4-hydroxyphenyl)-all-trans-retinamide has been found to prevent breast cancer in mammals.

Abstract: Antimicrobial compositions are provided wherein there is obtained an enhancement of the activity of an antimicrobial agent exemplified by quarternary ammonium compounds, bisdiguanides, anti-fungal agents, phenols, hydroxydiphenyls, carbanilides, salicylanilides, organo-metallic antiseptics, antibiotics, halogens, organic halogen derivatives and iodophores derived from nonionic surface active agents and from polyvinylpyrrolidone by combining the antimicrobial agent with an effective amount of a potentiator. The potentiator is a cyclohexyl phenol which may have a substituent on the phenyl ring selected from the group consisting of C.sub.1 to C.sub.3 alkyl and alkoxy, hydroxy, halo, amino and alkyl and dialkyl amino-substituents.These novel compositions find special applications as surgical scrub solutions, and for use in dressing topical wounds where the presence of blood and wound exudate would otherwise inhibit the action of the antimicrobial agent if it were to be used alone.

Abstract: Polymers useful in compositions and methods for preventing the attachment of dental plaque to the surface of the teeth of mammals comprise certain sulfonated polyamino acids and salts thereof in a pharmaceutically acceptable vehicle and the periodic application thereof to teeth.

Abstract: Novel N-(4-acyloxyphenyl)-all-trans-retinamide compounds are useful in preventing epithelial cancer in mammals.

Abstract: Compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprise certain sulfonated bis(naphthoxy)alkanes and the pharmaceutically acceptable salts thereof. They are used in pharmaceutically acceptable vehicles that are periodically applied to teeth.

Abstract: Compounds useful in compositions and methods for preventing the attachment of dental plaque to the surfaces of the teeth of mammals comprise certain sulfonated bis(alkylphenoxy)alkanes and the pharmaceutically acceptable salts thereof. They are used in pharmaceutically acceptable vehicles that are periodically applied to teeth.